Browse our anti-FZD8 (FZD8) Antibodies

Human Frizzled Family Receptor 8 (FZD8) interaction partners

1. In OS tissues, miR (show MLXIP Antibodies)-520b was inversely correlated with FZD8 expression. FZD8 was upregulated in human spinal OS tissues and cell lines.

2. miR (show MLXIP Antibodies)-375 functions as a tumor-suppressive microRNA by directly acting upon FZD8, which may serve as a new therapeutic target to inhibit tumor metastasis in colorectal cancer

3. Elevated expression of TP53 (show TP53 Antibodies) target FZD8 promoted prostate cancer bone metastasis by activating the canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.

4. these findings suggest that miR (show MLXIP Antibodies)-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt/b-catenin signaling pathway and manipulation of miR (show MLXIP Antibodies)-100 may provide a promoting therapeutic strategy for cancer breast treatment.

5. Frizzled-8 has an important pro-inflammatory role and suggest that its expression is related to chronic bronchitis.

6. report the discovery of a human-accelerated regulatory enhancer (HARE5) of FZD8, a receptor of the Wnt pathway implicated in brain development and size

7. Study concludes that expression of Fzd8 is repressed in multiple cancers and suggest it may have a role as a tumor suppressor.

8. c-Met upregulated FZD8 through the ERK/c-Fos cascade in HN-CSC. Taken together, our results offer a preclinical proof-of-concept for targeting the c-Met/FZD8 signaling axis as a CSC-directed therapy to improve HNSCC treatment

9. We demonstrated an activation of Wnt-2 (show WNT2 Antibodies) signaling via the Frizzled-8 receptor in non-small cell lung cancer cells

10. These observations suggest that c-Jun is involved in APF-mediated inhibition for bladder tumor cell growth

Xenopus laevis Frizzled Family Receptor 8 (FZD8) interaction partners

1. Data suggest that Sizzled is unlikely able to antagonize Wnt (show WNT2 Antibodies) signaling; however, structure of Sizzled provides a framework for understanding full-length structure of secreted Frizzled-related proteins such as frizzled-8 and their interaction with and antagonism of Wnt (show WNT2 Antibodies) proteins such as Wnt-8 (show WNT8A Antibodies).

2. Xfz8 is involved in the process of normal epithelium formation in the developing pronephric duct and tubules after specific

Chimpanzee Frizzled Family Receptor 8 (FZD8) interaction partners

1. Human-chimpanzee differences in a FZD8 enhancer (HARE5) alter cell-cycle dynamics in the developing neocortex.

Mouse (Murine) Frizzled Family Receptor 8 (FZD8) interaction partners

1. Increasing amounts of soluble Frizzled8-cysteine-rich-domain protein modulated Wnt3a (show WNT3A Antibodies) signaling in a biphasic manner.

2. Fzd8 and beta-catenin (show CTNNB1 Antibodies) negatively regulate osteoclast differentiation independent of osteoblasts.

3. Study shows Flamingo (Fmi) and Frizzled (Fz) 8, members of noncanonical Wnt signaling, both express in and functionally maintain quiescent long-term hematopoietic stem cells.

4. study presents the structure of Xenopus Wnt8 (XWnt8 (show WNT8A Antibodies)) in complex with the mouse Fz8-cysteine-rich domain to a resolution of 3.25 A

5. studies suggest a dose-dependent regulation of signaling by Fz5 and Fz8 in optic fissure/disc formation and progenitor expansion

6. A major role for frizzled 4 (show FZD4 Antibodies) and frizzled 8 in controlling ureteric growth in the developing kidney.

7. analysis of the frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt (show WNT2 Antibodies) and Dkk1 (show DKK1 Antibodies) binding sites on LRP6 (show LRP6 Antibodies)

8. Several lines of evidence that the mouse Cristin/R-spondin family proteins function as Fzd8 and LRP6 (show LRP6 Antibodies) receptor ligands and induce the canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway, leading to TCF (show HNF4A Antibodies)-dependent gene activation, are presented.

9. Molecular modeling of the complex between the xWNT8 (show WNT8A Antibodies) protein and the CRD (show CRX Antibodies) domain of mFZD8

10. Insulin-like growth-factor-binding protein-4 (show IGFBP4 Antibodies) physically interacted with a Wnt receptor, Frizzled 8 (Frz8), and a Wnt (show WNT2 Antibodies) co-receptor, low-density lipoprotein receptor-related protein 6 (LRP6 (show LRP6 Antibodies)), and inhibited the binding of Wnt3A (show WNT3A Antibodies) to Frz8 and LRP6 (show LRP6 Antibodies)