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anti-Human IGFBP5 Antibodies:
anti-Mouse (Murine) IGFBP5 Antibodies:
anti-Rat (Rattus) IGFBP5 Antibodies:
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Data suggest that IGFBP5 nuclear import is mediated by KPNA5 (show KPNA5 Antibodies)/KPNB1 (show KPNB1 Antibodies) complex; nuclear localization sequence of IGFBP5 is critical domain in this nuclear translocation. (IGFBP5 = insulin-like growth factor binding protein-5; KPNA5 (show KPNA5 Antibodies) = karyopherin subunit alpha-5 (show KPNA5 Antibodies); KPNB1 (show KPNB1 Antibodies) = karyopherin subunit beta-1/importin-beta (show KPNB1 Antibodies))
These results suggest that the C-terminus of IGFBP-5 exerts anti-cancer activity by inhibiting angiogenesis via regulation of the Akt (show AKT1 Antibodies)/ERK (show EPHB2 Antibodies) and NF-kB-VEGF (show VEGFA Antibodies)/MMP-9 (show MMP9 Antibodies) signaling pathway.
AMP (show APRT Antibodies)-IBP5 markedly enhanced keratinocyte migration and proliferation. AMP (show APRT Antibodies)-IBP5-induced keratinocyte activation was mediated by Mrg (show FABP7 Antibodies) X1-X4 receptors with MAPK (show MAPK1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) pathways.
Factor Xa (show F10 Antibodies) induced endothelial cell senescence through IGFBP-5.
Co-ordinated and reciprocal alteration in IGFBP-2 (show IGFBP2 Antibodies) and -5 expression may play a role in the acquisition of endocrine resistance in breast cancer.
The findings suggest that miR (show MLXIP Antibodies)-140 suppresses colorectal cancer progression and metastasis, possibly through downregulating ADAMTS5 (show ADAMTS5 Antibodies) and IGFBP5.
MiR (show MLXIP Antibodies)-137 inhibited cell proliferation and migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating the mTOR (show FRAP1 Antibodies)/STAT3 (show STAT3 Antibodies) signaling.
dysregulation of DNMT3A (show DNMT3A Antibodies) and IGFBP5 is relevant to preeclampsia. Thus, we propose that DNMT3A (show DNMT3A Antibodies) and IGFBP5 can serve as potential markers and targets for the clinical diagnosis and therapy of preeclampsia.
IGFBP5 promoter and exon-I methylation did not have any differences between tumor and adjacent tissues so that IGFBP5 methylation did not change IGFBP5 gene regulation in breast cancer.
IGFBP5 promoted osteogenic differentiation potentials of periodontal ligament stem cells and Wharton's jelly umbilical cord stem cells via the JNK (show MAPK8 Antibodies) and MEK (show MAP2K1 Antibodies)/Erk (show EPHB2 Antibodies) signalling pathways.
Data demonstrate that dysregulation of miR (show MLXIP Antibodies)-143-3p:Igfbp5 interactions in satellite cells with age may be responsible for age-related changes in satellite cell function.
proliferation of IGFBP5-mutated cancer cells is selectively blocked by IGF-1R (show IGF1R Antibodies) inhibitors
Results from mouse models suggest that inhibiting the up-regulation of IGFBP5 expression in peripheral nerves might prevent or slow down diabetic neuropathy disease progression
IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5 (show DOK5 Antibodies). IGFBP-5 and DOK5 (show DOK5 Antibodies) are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis.
Igfbp2 (show IGFBP2 Antibodies)-5 are expressed in distinct and complementary patterns during cochlear development.
indicate that Igf1 (show IGF1 Antibodies) was highly expressed in the mesenchyme, Igf2 and Igf1r (show IGF1R Antibodies) were expressed in both the midline epithelium and surrounding mesenchyme, and Igfbp5 was highly expressed in the epithelium.
we have identified a single polymorphic locus that affects skin and lung tumorigenesis and identify Igfbp5 and Igfbp2 (show IGFBP2 Antibodies) as candidate modifier genes of lung tumorigenesis.
investigated the effect of IGFBP5 induction on the progression of liver fibrosis caused by chronic cholangiopathy; expression of IGFBP5 in the Abcb4 (show ABCB4 Antibodies)-/- mice reduces inflammation, oxidative stress, ECM (show MMRN1 Antibodies) deposition and hepatocyte proliferation, thereby reducing liver fibrosis
c-Src (show SRC Antibodies) and IL-6 (show IL6 Antibodies) inhibit osteoblast differentiation and integrate IGFBP5 signalling
Defining the disulfide bonds of insulin-like growth factor-binding protein-5 by tandem mass spectrometry with electron transfer dissociation and collision-induced dissociation.
IGFBP5, an important component of IGF signaling pathway, contributes greatly to bovine muscle cell development. A mechanism that miR (show MYLIP Antibodies)-143 can regulate the proliferation and differentiation of bovine MSCs through changing expression of IGFBP5 was elucidated by our study.
This study suggested that that higher level IGFBP-5 expression may have functional significance in lactation persistency.
follicular dominance was associated with low or decreased follicular fluid concentrations of IGFBP-4 (show IGFBP4 Antibodies) and -5
GH reduces mRNA and protein expression of IGFBP-5 in bovine mammary epithelial cells, but it does not affect the expression of IGFBP-3 (show IGFBP3 Antibodies)
The present study revealed SNPs in exon 1 of IGFBP-5 gene (show GPD1 Antibodies) in the Tibet Mini-pig, possibly providing more understanding of the mechanism of miniaturization
IGFBP-5 gene (show GPD1 Antibodies) is associated with the variation in meat quality, especially in pH value together with other QTLs on chromosome 15.
Endogenous IGFBP-5 or transiently expressed IGFBP-5-EGFP is localized in the nuclei of VSMCs. It possesses transcription-regulatory activity that is IGF independent.
The transgene in the cell clones was examined by polymerase chain reaction to verify that exogenous DNA (pKAP6-1 and IGFBP-5) had integrated stably into GFb cells
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
insulin-like growth factor binding protein 5
, IGF-binding protein 5
, insulin-like growth factor-binding protein 5
, insulin-like growth factor binding protein-5