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IGFBP6 might be an important regulator and prognostic factor for glioma.
Results suggest that insulin like growth factor binding protein 6 (IGFBP6) may be an independent prognostic biomarker for nasopharyngeal carcinoma (NPC (show NPC1 Proteins)).
We identified a novel SNP variant, Chr12:g.53494591T>C. c.T430C (p.S144P) in the insulin-like growth factor binding protein-6 (IGFBP6) gene. This variant was shared by all affected family members, but not by unaffected members. The c.T430C (p.S144P) variant of IGFBP6 was identified as the likely causal variant associated with increased risk of familial disc degeneration in the studied pedigree.
We found that IGFBP6 and SATB2 (show SATB2 Proteins) were significantly down-regulated in HIV-infected CEM*174 cells and 3 different cohorts of HIV/AIDS patients while their promoters were predominantly hyper-methylated compared with normal controls.
IGFBP6 attenuation in ACTH (show POMC Proteins)-secreting pituitary adenomas is associated with tumor growth, through activation of PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) pathway
CCL-18 (show CCL18 Proteins) and IGFBP-6 were identified as new potential serum biomarkers for prostate cancer.
When the concentrations of IGFBP-6 or KNG1 (show KNG1 Proteins) were greater than 98.5 pg/ml or 88.5 ng/ml, respectively, they predicted the proliferative vitreoretinopathy prognosis.
Our results indicate that IGF2 and IGFBP6 appear to govern various regulatory feedback mechanisms in periodontal ligament cells
Data indicate that IGFBP-6 binds to prohibitin-2 (show PHB2 Proteins) on the cell membrane, and knockdown of the latter abrogates IGFBP-6-induced migration.
This is the first report to implicate IGFBP-6 as a suppressor of cellular proliferation and IGF-II as an inducer of cellular contractility in this connective tissue disease.
Genome-wide methylation analysis showed that two genes with hypomethylated promoters, Igfbp6 and Foxs1, are upregulated in GDX (show UBL4A Proteins)-induced adrenocortical neoplasms.
Igfbp-6 is a target of sonic hedgehog (show SHH Proteins) signaling in the urogenital sinus
These results reveal a novel function for MMP-9 (show MMP9 Proteins) and -12 in developmental myelination likely through regulating IGF-1 (show IGF1 Proteins) bioavailability.
Report multiple post-translational modifications of mouse insulin-like growth factor binding protein-6 expressed in epithelial Madin-Darby canine kidney cells.
high-affinity IGF binding ptotein with substantially greater affinity for insulin-like growth factor-II (IGF-II) than IGF-I
, IGF binding protein 6
, IGF-binding protein 6
, insulin-like growth factor-binding protein 6
, INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 6 PRECURSOR (IGFBP-6) (IBP-6) (IGF-BINDING PROTEIN 6)
, insulin-like growth factor binding protein 6