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Data suggest that LEF1-dependent genes in zebrafish hypothalamus are associated with anxiety; LEF1 null mutant zebrafish exhibit increased anxiety.
mesodermal Wnt3a (show WNT3A ELISA Kits)-mediated signaling via the transcription factor Lef1 positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 (show GATA1 ELISA Kits) expression) in zebrafish embryos.
Amotl2a (show AMOTL2 ELISA Kits) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 (show YAP1 ELISA Kits) and the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) effector Lef1.
Lef1 has a role in regulating Dusp6 (show DUSP6 ELISA Kits) in formation of the zebrafish posterior lateral line primordium
Nlk2 (show NLK ELISA Kits) is essential for the phosphorylation and activation of Lef1 transcriptional activity in neural progenitor cells.
Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium.
Lef1 sustains proliferation of leading zone progenitors, maintaining the primordium size and defining neuromast deposition rate.
Data conclude that lef1-mediated Wnt (show WNT2 ELISA Kits) signaling is involved in various aspects of primordium migration, although part of this implication is masked by a high level of developmental redundancy.
Data show cooperation between Dnmt3 and an H3K9 methyltransferase G9a (show EHMT2 ELISA Kits) in regulating lef1.
high-affinity binding sites for Tcf (show HNF4A ELISA Kits)/Lef1 within the boz promoter region
Lef1 and Tcf1 (show HNF1A ELISA Kits) showed oncogenic effect in colonic carcinogenesis. Cellular context of miRNAs might play important roles in carcinogenesis by altering the expression pattern of Lef/Tcfs members.
Data (including data from studies using transgenic/knockout mice) suggest that expression of Lef1 in hypothalamus inhibits anxiety and regulates neurogenesis; expression of Lef1 in hypothalamus is required for neurogenesis.
Uncovering a Pitx2 (show PITX2 ELISA Kits)-Sox2 (show SOX2 ELISA Kits)-Lef-1 transcriptional mechanism that regulates dental epithelial stem cells homeostasis and dental development.
this study shows that the transcription factors Tcf1 (show HNF1A ELISA Kits) and Lef1 suppress CD4 (show CD4 ELISA Kits)+ T lineage genes in CD8 (show CD8A ELISA Kits)+ T cells through intrinsic histone deacetylase (show HDAC1 ELISA Kits) activity
leukemic stem cells are therefore more sensitive to loss of Tcf1 (show HNF1A ELISA Kits) and Lef1 than Hematopoietic Stem Cells in their self-renewal capacity.
Sp5/8 bind directly to GC boxes in Wnt (show WNT2 ELISA Kits) target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1 (show HNF1A ELISA Kits)/lymphoid enhancer factor (Lef) 1 to facilitate recruitment of beta-catenin (show CTNNB1 ELISA Kits) to target gene enhancers.
This paper demonstrates a cell-intrinsic requirement for transcription factors TCF1 (show HNF1A ELISA Kits) and LEF1 for the development of all subsets of Natural Killer T cells.
this study gives new insights into transcriptional regulating mechanisms of Wnt (show WNT2 ELISA Kits)-mediated Isl1 (show ISL1 ELISA Kits) expression during cardiomyocyte differentiation.
data reveal LEF1 as a central regulator of iNKT cell number and Th2-type effector differentiation.
These findings provide evidence for the existance of a posititve feedback loop connecting survivin expression in tumor cells to PI3K/Akt enhanced beta-catenin-Tcf/Lef-dependent transcription followed by secretion of VEGF and angiogenesis.
Tcf (show HNF4A ELISA Kits)/Lef genes encode factors of different activities, which function together in antagonistic or synergistic ways to modulate the intensity and outcome of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signalling and to trigger tissue-specific responses.
Interaction of Xom and LEF1/TCF (show HNF4A ELISA Kits)-factors is essential for ventral cell fate determination and LEF1/TCF (show HNF4A ELISA Kits) factors may function as a point of convergence to mediate the combined signaling of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) and BMP4 (show BMP4 ELISA Kits)/Xom pathways during early embryogenesis.
Knockdown of GATA6 (show GATA6 ELISA Kits) completely eliminated the effect of TCF1 (show HNF1A ELISA Kits), while forced expression of GATA6 (show GATA6 ELISA Kits) induced hESC differentiation
Data indicate that microRNA miR (show MLXIP ELISA Kits)-27a directly targets GSK-3beta (show GSK3b ELISA Kits) and increases expression of beta-catenin (show CTNNB1 ELISA Kits) and LEF1 in all-trans-retinoic acid (ATRA)-induced Hep2 cells.
and CTU1/2, partner enzymes in U34 methoxycarbonylmethyl-2-thio (show ACAA1 ELISA Kits) tRNA modification, are up-regulated in human breast cancers and sustain metastasis.
EVI1 (show MECOM ELISA Kits) transcription is directly regulated by LEF1/beta-catenin (show CTNNB1 ELISA Kits) complex in myeloid blast crisis of chronic myeloid leukemia (show BCL11A ELISA Kits). Loss of p53 (show TP53 ELISA Kits) function as a key regulator for beta-catenin (show CTNNB1 ELISA Kits)-EVI1 (show MECOM ELISA Kits) in myeloid blast crisis of chronic myeloid leukemia (show BCL11A ELISA Kits).
LEF1 is a sensitive and specific marker for chronic lymphocytic B-cell leukemia
a frequency of 4-9% expression of LEF1 bymantle cell lymphoma
The results suggest a role for beta-catenin (show CTNNB1 ELISA Kits)/LEF1-mediated transcription in both malignant transformation and metastasis of prostate cancer
The results describe a novel mutation in LEF1 causing dysregulation of Wnt/B catenin signaling in eyelid sebaceous cancinoma
LEF-1 and MITF (show MITF ELISA Kits) regulate tyrosinase (show TYR ELISA Kits) gene transcription in vitro via binding to its promoter.
The molecular characterisation of the porcine LEF1 gene and its association with number of teats and inverted teats in experimental and commercial populations, is described.
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.
lymphoid enhancer binding factor-1
, lymphoid enhancer-binding factor 1
, lymphoid enhancer-binding factor 1-like
, lymphoid enhancer binding factor 1 short isoform
, T cell-specific transcription factor 1-alpha
, lymphiod enhancer binding factor 1
, transcription factor LEF-1
, lymphoid enhancer binding factor 1