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a primary functional variant of PRKCB (rs35015313) was identified by genotype imputation using a phased panel of 1,070 Japanese individuals from a prospective, general population cohort study and subsequent in vitro functional analyses. These results may lead to improved understanding of the disease pathways involved in primary biliary cholangitis.
our findings identify PRKCB gene as a novel candidate gene for familial Meniere's Disease (MD )and its expression gradient in supporting cells of the organ of Corti deserves attention, given the role of supporting cells in K(+ )recycling within the endolymph, and its apical turn location may explain the onset of hearing loss at low frequencies in MD
Activation of the Pro-Oxidant PKCbetaII-p66Shc (show SHC1 ELISA Kits) Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Patients With Diabetes With Critical Limb Ischemia
Taken together, these data argue for a complex mechanism of PKC-beta-dependent regulation of SH (show POLD3 ELISA Kits)CA (p66) activation invol (show SIGLEC1 ELISA Kits)ving Ser(139) and a motif surroun (show SIGLEC1 ELISA Kits)ding Ser(213).
The study aimed to identify a small set of genetic signatures that may reliably predict the individuals with a high genetic propensity to heroin addiction. A set of 4 genes (JUN (show JUN ELISA Kits), CEBPB (show CEBPB ELISA Kits), PRKCB, ENO2 (show ENO2 ELISA Kits), or CEBPG (show CEBPG ELISA Kits)) could predict the diagnosis of heroin addiction with the accuracy rate around 85% in our dataset.
Our results provide compelling evidence that glucose-induced PKCalpha (show PKCa ELISA Kits)/PKCbeta-mediated inhibition of Kv current in vascular smooth muscle causes an enhanced constrictor response. Inhibition of Kv current causes a significant depolarization of vascular myocytes leading to marked vasoconstriction
Data suggest that targeted manipulation of protein kinase C (show PKC ELISA Kits) isoforms PKCalpha (show PKCa ELISA Kits), PKCbeta, and PKCeta might be beneficial in certain proteinuric kidney diseases with altered transient receptor potential cation channel subfamily C member 6 (show TRPC6 ELISA Kits) protein (TRPC6 (show TRPC6 ELISA Kits)) functions.
Bone marrow stroma-induced resistance of chronic lymphocytic leukemia cells to arsenic trioxide involves Mcl-1 upregulation and is overcome by inhibiting the PI3Kdelta or PKCbeta signaling pathways.
PPAR-delta (show PPARD ELISA Kits) and NKIRAS1 are downstream mediators in the PRKCB pathway in human umbilical vein endothelial cells.
Lower hydrogen sulfide is associated with cardiovascular mortality, which involves PKCBII/Akt (show AKT1 ELISA Kits) pathway in chronic hemodialysis patients.
propose that PKCbeta acts to suppress the degradation of FTO (show FTO ELISA Kits) protein and reveals the associated role of PKCbeta and FTO (show FTO ELISA Kits) in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases
Cytosolic NELL2 specifically interacts with PKC beta isotypes and inhibits PKC beta1 through direct binding to the N-terminal pseudosubstrate domain of PKC beta1.
Taken together, these data argue for a complex mechanism of PKCbeta-dependent regulation of p66 (show POLD3 ELISA Kits) activation involving Ser (show SIGLEC1 ELISA Kits)(139) and a motif surrounding Ser (show SIGLEC1 ELISA Kits)(213).
Translocation of PKC-betaII from the cytoplasm to membranes is required for phagocytosis of apoptotic cells and is inhibited by soluble beta-glucan
repressor of myogenesis; opposes calcineurin function
at the functionally mature calyx of Held synapse the Ca(2 (show CA2 ELISA Kits)+)-dependent protein kinase C (show PKC ELISA Kits) isoforms alpha and beta are necessary for post-tetanic potentiation, a form of plasticity thought to underlie short-term memory
a new mechanism by which PKC-beta activation promotes EC dysfunction caused by the de-regulation of the IL-18 (show IL18 ELISA Kits)/IL-18BP (show IL18BP ELISA Kits) pathway, leading to increased VCAM-1 (show VCAM1 ELISA Kits) expression, monocyte/macrophage adhesion, and accelerated atherosclerotic plaque formation in diabetes
These results demonstrate the importance of PKCbetaII in chronic lymphocytic leukemia-like disease progression and suggest a role for PKCalpha (show PKCa ELISA Kits) subversion in creating permissive conditions for leukemogenesis.
PKCbeta2 inhibition protects mice from gut (show GUSB ELISA Kits) ischemia-reperfusion injury by suppressing the adaptor p66(Shc)-mediated oxidative stress and subsequent apoptosis.
PKC-alpha (show PKCa ELISA Kits) and -betaIotaIota are the predominant isoforms in the developing optic pathway, whereas PKC-epsilon (show PRKCE ELISA Kits) is the major form in the chiasmatic neurons.
The study identified the serine phosphorylation (p-Ser (show SIGLEC1 ELISA Kits)) sites induced by PKC-Beta activation or AGT (show AGT ELISA Kits), which inhibits insulin (show INS ELISA Kits)-induced p-Tyr (show TYR ELISA Kits) sites on IRS2 (show IRS2 ELISA Kits) and its signals in endothelial cells.
ET-1 (show EDN1 ELISA Kits)-mediated myocardial contractile dysfunction during cardioplegia involves activation of protein kinase C beta II.
The PKCalpha (show PKCa ELISA Kits), PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
Increases in epicardial perivascular adipose tissue leptin (show LEP ELISA Kits) exacerbate coronary endothelial dysfunction in MetS (show MARS ELISA Kits) via a PKC-beta-dependent pathway.
first study to show the expression and cellular localization of PKC beta I in the retina of pigs with development, and these results suggest that PKC beta I, in accordance with PKC alpha (show PKCa ELISA Kits), plays important roles in signal transduction pathways in the pig retina with development
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, protein kinase C beta type
, protein kinase C, beta 1 polypeptide
, protein kinase C beta-II
, protein kinase C, beta 1
, protein kinase C beta I
, protein kinase C beta II
, protein kinase C beta 1
, protein kinase C, beta
, protein kinase C beta 2