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anti-Human SFRP1 Antibodies:
anti-Mouse (Murine) SFRP1 Antibodies:
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Human Polyclonal SFRP1 Primary Antibody for IF (p), IHC (p) - ABIN674694
Wang, Xie, Xie, Wan, Ma, Qi, Yang: MiR-27a regulates Wnt/beta-catenin signaling through targeting SFRP1 in glioma. in Neuroreport 2015
Cow (Bovine) Polyclonal SFRP1 Primary Antibody for WB - ABIN2792235
Caldwell, Jones, Taniere, Warrack, Soon, Matthews, Morton: The Wnt antagonist sFRP1 is downregulated in premalignant large bowel adenomas. in British journal of cancer 2006
Show all 2 Pubmed References
Human Polyclonal SFRP1 Primary Antibody for ELISA, IHC - ABIN4353134
Gumz, Zou, Kreinest, Childs, Belmonte, LeGrand, Wu, Luxon, Sinha, Parker, Sun, Ahlquist, Wood, Copland: Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007
lost SFRP1 expression-induced Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling due to the hypermethylation of the SFRP1 promoter could associate with keloid development
miR (show MLXIP Antibodies)-1301-3p promoted the expansion of prostate cancer stem cells by inhibiting GSK3beta and SFRP1, and activating the Wnt (show WNT2 Antibodies) pathway.
Methylation level of the SFRP1 promoter region is increased in patients with RCC (show XRCC1 Antibodies) compared to normal controls and might be involved in the occurrence and development of RCC (show XRCC1 Antibodies).
Methylation of SFRP1, SFRP2, SDC2, and PRIMA1 promoter sequences was observed in 85.1%, 72.3%, 89.4%, and 80.9% of plasma samples from patients with Colorectal cancer and 89.2%, 83.8%, 81.1% and 70.3% from adenoma patients, respectively.
preliminary data show loss of SFRP1 protein expression caused by the SFRP1 promoter hypermethylation in a subset of high-grade serous ovarian carcinomas
Loss of SFRP1 likely contributes to tumor progression by altering the expression of a critical transcription factor in both the epithelium and the immune system.
Authors found that downregulation of HP1alpha (show CBX5 Antibodies) can decrease H3K9me3 enrichment and DNA methylation (show HELLS Antibodies) rate of secreted frizzled-related protein 1 (SFRP1) promoter, resulting in restoring the expression of SFRP1.
KL and SFRP1 methylation were more predominant in nasopharyngeal tumors.
Results indicate that SFRP1 rs7832767 C > T, CTNNB1 (show CTNNB1 Antibodies) rs2293303 C > T, and WISP1 (show WISP1 Antibodies) rs16893344 C > T were all strongly correlated with myocardial infarction (MI) susceptibility.
miR (show MLXIP Antibodies)-1254 promotes lung cancer cell proliferation by targeting the expression of SFRP1.
The results of this study indicated that Shh (show SHH Antibodies), Sfrp1, and Wnt5a (show WNT5A Antibodies) collaborate to direct the pathfinding of descending 5-HT (show DDC Antibodies) axons in the brainstem
OVOL1 (show OVOL1 Antibodies)-regulated Fst (show FST Antibodies) and SFRP1 affect hair inductive potency of neonatal dermal cells.
Down stream actions of estrogen-mediated signaling, including cellular proliferation and progesterone receptor (show PGR Antibodies) transcription, are elevated in estradiol treated explant cultures derived from Sfrp1(-/-) mice.
Study suggests that the induction of the WNT (show WNT2 Antibodies) pathway is a potentially crucial pathway in the development of cardiomyopathy with aging with sFRP-1 being a critical factor in maintaining normal cardiovascular structure and function during this process.
the expression of Sfrp1 is a critical factor required for maintaining appropriate cellular signaling in response to the onset of obesity
findings suggest that SFRP1 expression in the adult maintains progenitor cells within their undifferentiated state and suggests that manipulation of this pathway is a potential target to augment the lung repair process during disease
Sfrp1 is required for inhibition of renal damage through the non-canonical Wnt (show WNT2 Antibodies)/PCP (show BMP1 Antibodies) pathway in a mouse model of obstructive nephropathy
SFRP1 deficiency in mice results in the development of diet-induced obesity aggravated by inflammation and breast cancer.
Sfrp1(-/-) mice have less DNA fragmentation, whilst caspase-3 (show CASP3 Antibodies) expression is decreased, and that p53 (show TP53 Antibodies) expression is generally diminished.
Results show the expression level of SFRP1 significantly higher in the embryonic skeletal muscle and diminishes after, whereas miR-206/1 show the inverse. Also, SFRP1 gene is regulated by miR-1/206 and potentially affects skeletal muscle development.
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling\; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
, secreted apoptosis-related protein 2
, secreted frizzled-related sequence protein 1
, frizzled in aorta protein
, frzA protein
, secreted frizzled related protein 1
, secreted frizzled-related protein 1
, Secreted frizzled-related protein 1
, secreted frizzled-related protein 1b