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anti-Human SFRP1 Antibodies:
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Human Polyclonal SFRP1 Primary Antibody for FACS, IHC (p) - ABIN652980
Huang, Yu, Deng, Sheng, Peng, Qin, Du: SFRP4 was overexpressed in colorectal carcinoma. in Journal of cancer research and clinical oncology 2010
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Cow (Bovine) Polyclonal SFRP1 Primary Antibody for WB - ABIN2792235
Caldwell, Jones, Taniere, Warrack, Soon, Matthews, Morton: The Wnt antagonist sFRP1 is downregulated in premalignant large bowel adenomas. in British journal of cancer 2006
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Human Polyclonal SFRP1 Primary Antibody for ELISA, IHC - ABIN4353134
Gumz, Zou, Kreinest, Childs, Belmonte, LeGrand, Wu, Luxon, Sinha, Parker, Sun, Ahlquist, Wood, Copland: Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Human Polyclonal SFRP1 Primary Antibody for IF (p), IHC (p) - ABIN674694
Wang, Xie, Xie, Wan, Ma, Qi, Yang: MiR-27a regulates Wnt/beta-catenin signaling through targeting SFRP1 in glioma. in Neuroreport 2015
active involvement in placental development and important role in pathology of pregnancy
SFRP1 gene was epigenetically silenced in glioblastomas when compared to low astrocytoma grades, which may suggest that the lack of its protein is involved in astrocytoma progression.
It has been found that miR-27a-3p modulated the Wnt/beta-catenin signaling pathway to promote epithelial-mesenchymal transition in oral squamous carcinoma stem cells by down-regulating SFRP1.
sFRP1 overexpression in gastric cancer cells leads to increased cell proliferation and angiogenesis.
Study determined that SFRP1 is downregulated during tumor formation probably by DNA methylation, and associates consistently with tumor suppressive functions.
co-transfection of sFRP1 siRNA with miR- 191 inhibitor sequence, it was found that the Wnt/beta-catenin signaling pathway was reactivated and the colony formation ability of RBE cells was restored.
WNT5b rs3803164, and SFRP1 rs3242 were significantly associated with lumbar spine BMD.
lost SFRP1 expression-induced Wnt/beta-catenin signaling due to the hypermethylation of the SFRP1 promoter could associate with keloid development
miR-1301-3p promoted the expansion of prostate cancer stem cells by inhibiting GSK3beta and SFRP1, and activating the Wnt pathway.
Methylation level of the SFRP1 promoter region is increased in patients with RCC compared to normal controls and might be involved in the occurrence and development of RCC.
Methylation of SFRP1, SFRP2, SDC2, and PRIMA1 promoter sequences was observed in 85.1%, 72.3%, 89.4%, and 80.9% of plasma samples from patients with Colorectal cancer and 89.2%, 83.8%, 81.1% and 70.3% from adenoma patients, respectively.
preliminary data show loss of SFRP1 protein expression caused by the SFRP1 promoter hypermethylation in a subset of high-grade serous ovarian carcinomas
Loss of SFRP1 likely contributes to tumor progression by altering the expression of a critical transcription factor in both the epithelium and the immune system.
Authors found that downregulation of HP1alpha can decrease H3K9me3 enrichment and DNA methylation rate of secreted frizzled-related protein 1 (SFRP1) promoter, resulting in restoring the expression of SFRP1.
KL and SFRP1 methylation were more predominant in nasopharyngeal tumors.
Results indicate that SFRP1 rs7832767 C > T, CTNNB1 rs2293303 C > T, and WISP1 rs16893344 C > T were all strongly correlated with myocardial infarction (MI) susceptibility.
miR-1254 promotes lung cancer cell proliferation by targeting the expression of SFRP1.
The expression of Dicer negatively correlated with that of SFRP1 and it appeared to promote CCA cell proliferation.
H2O2-induced SFRP1 gene demethylation contributes to H2O2-induced apoptosis in human U251 glioma cells.
Data suggest that microRNA miR-27a may activate the Wnt/beta-catenin signaling pathway by negatively regulating SFRP1 to promote the proliferation, migration and invasion of breast cancer (BC) cells.
Results show the expression level of SFRP1 significantly higher in the embryonic skeletal muscle and diminishes after, whereas miR-206/1 show the inverse. Also, SFRP1 gene is regulated by miR-1/206 and potentially affects skeletal muscle development.
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling\; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
, secreted apoptosis-related protein 2
, secreted frizzled-related sequence protein 1
, frizzled in aorta protein
, frzA protein
, secreted frizzled related protein 1
, secreted frizzled-related protein 1
, Secreted frizzled-related protein 1
, secreted frizzled-related protein 1b