Browse our SFRP5 Proteins (SFRP5)

Zebrafish Secreted Frizzled-Related Protein 5 (SFRP5) interaction partners

1. note an increase in BMP ligand expression in Sfrp1a/5 depleted embryos, a phenotype similar to that seen in embryos with inhibited BMP signaling

2. Sfrp5 inhibits both canonical and non-canonical Wnt (show WNT2 Proteins) signaling during embryonic and endodermal development

Xenopus laevis Secreted Frizzled-Related Protein 5 (SFRP5) interaction partners

1. propose that XsFRP5 exerts an early regulatory function in the specification of the ventral pancreas, as well as a late function in controlling stomach size via inhibition of Wnt (show WNT2 Proteins) signalling

Human Secreted Frizzled-Related Protein 5 (SFRP5) interaction partners

1. This review article focuses on the effects of SFRP5 on the major systems of the body and on its association with the Wnt (show WNT2 Proteins) signaling pathways--{review}

2. SFRP5 confers protection against oxidative stress-induced (show SQSTM1 Proteins) apoptosis through inhibition of beta-catenin (show CTNNB1 Proteins) activation and downregulation of Bax (show BAX Proteins).

3. The inverse association of serum Sfrp5 with beta-cell function suggests a detrimental role of Sfrp5 for insulin (show INS Proteins) secretion also in humans. The severity of NAFLD does not appear to affect this relationship. The weak association between serum Sfrp5 and insulin (show INS Proteins) sensitivity was partially explained by body mass.

4. Results identify several coding and non-coding variants in the sFRP5 gene region, the majority of which resulted in a non-synonymous amino acid change in the protein. One of the variants (c.-3G[A) shows a trend towards association between the variant frequency and the obese phenotype.

5. Results indicate that miR (show MLXIP Proteins)-125b can regulate SFRP5 expression and thus influence the growth and activation of cardiac fibroblasts.

6. Decreased first trimester serum Sfrp-5 levels are significantly associated with the increased risk of gestational diabetes mellitus.

7. Report reduced hepatic SFRP5 expression in morbidly women with NAFLD.

8. Data suggest that serum SFRP5 levels are up-regulated in subjects with newly diagnosed type 2 diabetes as compared to prediabetic or control subjects; subjects were matched for obesity/overweight/body mass index.

9. Serum WISP2 (show WISP2 Proteins) correlated directly with fatty acid binding protein 4. Serum SFRP5 did not differ between obese (n=32) vs. nonobese (n=25) PCOS women, but reference women had lower SFRP5 (p<5x10(-6) as compared to both PCOS groups).

10. Sfrp5 represents a candidate for a mature adipocyte marker gene.

Mouse (Murine) Secreted Frizzled-Related Protein 5 (SFRP5) interaction partners

1. SFRP5 be a target gene of PPARgamma (show PPARG Proteins).

2. The balance of factors controlling fat deposition can be evaluated in part by the differential expression profiles of Mest (show MEST Proteins) and Sfrp5 genes with functions linked to fat deposition as long as there is an active accumulation of fat mass.

3. the expression of Mest (show MEST Proteins) and Sfrp5 were tightly associated across the 5 mouse strains with the highest and lowest expression occurring in DBA (show RPS19 Proteins)/2J and C57BL/6J (B6) respectively suggesting a common mechanism for their regulation.

4. MicroRNA-124 regulates cell specification in the cochlea through modulation of Sfrp4 (show SFRP4 Proteins) and Sfrp5.

5. although high sFRP5 expression inhibits B-lymphopoiesis in vivo, physiologically, it contributes to the preservation of very primitive lymphopoietic progenitors, including hematopoietic stem cells, under high estrogen levels

6. A role for SFRP5 in glucose metabolism and pancreatic beta-cell function indicates that the use of an anti-SFRP5 mAb as a potential approach to treat type 2 diabetes.

7. Sfrp5 mRNA expression and protein secretion depend on the differentiation of adipocytes. The dysregulation of Sfrp5 expression and secretion is directly correlated with insulin (show INS Proteins) resistance.

8. We propose that Ift88 (show IFT88 Proteins) and primary cilia regulate expression of Sfrp5 and Wnt (show WNT2 Proteins) signaling pathways in growth plate via regulation of Ihh (show IHH Proteins) signaling.

9. early progeny of Sox2 (show SOX2 Proteins)-positive stem cells transiently expressed the Wnt (show WNT2 Proteins) inhibitor Sfrp5

10. SFRP5 inhibits WNT (show WNT2 Proteins) signaling to suppress oxidative metabolism and stimulate adipocyte growth during obesity.