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This is the first time the protein partners of either E2A-PBX1 (show PBX1 Proteins) or HOXA9 (show HOXA9 Proteins) oncoproteins were identified using an unbiased biochemical approach. The identification of translation initiation factors associated with HOXA9 (show HOXA9 Proteins) might indicate a novel function for HOX (show MSH2 Proteins) proteins independent of their transcriptional activity.
Poly (ADP-ribose) polymerase (show PARP1 Proteins) inhibitors selectively induce cytotoxicity in TCF3-HLF (show EPAS1 Proteins)-positive leukemic cells.
MiR (show MLXIP Proteins)-138 may be a tumor suppressor and potential prognostic biomarker in cervical cancer. Its downstream target, TCF3, may also regulate cancer development in a reverse manner as miR (show MLXIP Proteins)-138.
High levels of TCF3 in gliomas promote glioma development through the Akt (show AKT1 Proteins) and Erk (show EPHB2 Proteins) pathways.
TWIST1 (show TWIST1 Proteins)-E12 (show ELSPBP1 Proteins) protein heterodimeric complexes may thus constitute the main active forms of TWIST1 (show TWIST1 Proteins) with regard to senescence inhibition over the time course of breast tumorigenesis.
Review of the role of the E2A-PBX1 (show PBX1 Proteins) gene rearrangement in the prognosis of childhood acute lymphoblastic leukemia and its central nervous system relapse.
Our data suggest that E2A antagonism of PU.1 activity contributes to its ability to commit multipotential hematopoietic progenitors to the lymphoid lineages.
E47 is a novel substrate of PAK5 (show PAK6 Proteins), and PAK5 (show PAK6 Proteins)-mediated phosphorylation of E47 promotes epithelial-mesenchymal transition. High expression of phospho-E47 was associated with an aggressive phenotype of colon cancer and metastasis.
report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects
We observed significant enrichment of the neuroactive ligand-receptor interaction pathway in TCF3-PBX1 (show PBX1 Proteins) as well as an enrichment of genes involved in immunity and infection pathways in ETV6 (show ETV6 Proteins)-RUNX1 (show RUNX1 Proteins) subtype
this study identifies E2A target genes in embryonic neural stem cells and demonstrates that E47 regulates neuronal differentiation via p57(KIP2 (show CDKN1C Proteins)).
If Gfi1 (show ZNF163 Proteins) levels fall below a threshold, Id1 (show ID1 Proteins) expression increases and renders E2A unable to function, which prevents hematopoietic progenitors from engaging along the B lymphoid lineage
these data identified E2A and E2-2 (show TCF4 Proteins) as central regulators of B cell immunity.
down-regulation of Id3 (show ID3 Proteins) in B cells is essential for releasing E2A and E2-2 (show TCF4 Proteins), which in a redundant manner are required for antigen-induced B cell differentiation.
Data suggest a novel mechanism of drug resistance in which E2a and PRC2 drive changes in the B-cell epigenome; these alterations attenuate alkylating agent treatment-induced apoptosis.
These findings suggest that miR (show MLXIP Proteins)-506-3p played an important role in regulating NSC proliferation and differentiation via targeting TCF3 (show TCF7L1 Proteins), and provide a promising avenue for future in-depth research into the functions of miR (show MLXIP Proteins)-506-3p and TCF3 (show TCF7L1 Proteins) in nervous system development.
Conditional expression of E2A-HLF (show HLF Proteins) induces B-cell precursor death and myeloproliferative-like disease in knock-in mice.
Upregulation of E12/E47 by HBx ultimately and concomitant repression of E-cadherin (show CDH1 Proteins) expression led to epithelial-mesenchymal transition in human hepatocytes.
Mechanistically, E47 repressed the expression of several astrocyte-specific genes in adult NSPCs.
Tcf3 (show TCF7L1 Proteins) is upregulated in skin wounds and Tcf3 (show TCF7L1 Proteins) overexpression accelerates keratinocyte migration and skin wound healing.
Data indicte that Tcf-1 (show HNF1A Proteins) and Lef-1 (show LEF1 Proteins) exhibit a function in the axis induction assay, which is lacking in Tcf-3 and -4.
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1\;19), with PBX1), childhood leukemia (t(19\;19), with TFPT) and acute leukemia (t(12\;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
VDR interacting repressor
, class B basic helix-loop-helix protein 21
, helix-loop-helix protein HE47
, immunoglobulin transcription factor 1
, kappa-E2-binding factor
, negative vitamin D response element-binding protein
, transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
, transcription factor E2-alpha
, transcription factor ITF-1
, vitamin D receptor-interacting repressor
, transcription factor 3
, immunoglobulin enhancer-binding factor E12/E47
, transcription factor A1
, transcription factor E2a
, pancreas specific transcription factor 1c
, transcription regulator Pan
, transcription factor XE12/XE47
, class A basic helix-loop-helix transcription factor G12
, helix-loop-helix protein E12
, helix-loop-helix protein E47
, transcription factor 7-like 1 (T-cell specific, HMG-box)