TCF3 Proteins

Protein Summary

This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1\;19), with PBX1), childhood leukemia (t(19\;19), with TFPT) and acute leukemia (t(12\;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.

Alternative names and synonyms associated with TCF3

• transcription factor 3 (TCF3) antibody
• transcription factor 3b (tcf3b) antibody
• transcription factor 3 (Tcf3) antibody
• transcription factor 3 L homeolog (tcf3.L) antibody
• transcription factor E2a (tcfe2a) antibody

• A1 antibody
• AA408400 antibody
• ALF2 antibody
• AW209082 antibody
• bhlhb21 antibody
• Show all synonym aliases
• e2a antibody
• E12 antibody
• E12/E47 antibody
• E47 antibody
• G12 antibody
• itf1 antibody
• ME2 antibody
• Pan1 antibody
• Pan2 antibody
• TCF-3 antibody
• tcf3a antibody
• TCF7L1 antibody
• tcfe2a antibody
• vdir antibody
• XE3 antibody
• xtcf-3 antibody
• xtcf3 antibody
• zgc:113045 antibody

Protein level used designations for TCF3

VDR interacting repressor , class B basic helix-loop-helix protein 21 , helix-loop-helix protein HE47 , immunoglobulin transcription factor 1 , kappa-E2-binding factor , negative vitamin D response element-binding protein , transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) , transcription factor E2-alpha , transcription factor ITF-1 , vitamin D receptor-interacting repressor , transcription factor 3 , TCF-3 , immunoglobulin enhancer-binding factor E12/E47 , transcription factor A1 , transcription factor E2a , pancreas specific transcription factor 1c , transcription regulator Pan , transcription factor XE12/XE47 , class A basic helix-loop-helix transcription factor G12 , helix-loop-helix protein E12 , helix-loop-helix protein E47 , transcription factor 7-like 1 (T-cell specific, HMG-box)