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Human WNT1 Protein expressed in Escherichia coli (E. coli) - ABIN413893
Tawk, Makoukji, Belle, Fonte, Trousson, Hawkins, Li, Ghandour, Schumacher, Massaad: Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
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maternal Wnt (show WNT2 Proteins)/STOP signaling, but not beta-catenin (show CTNNB1 Proteins) signaling, has a role in cleavage after fertilization and cell cycle progression
sfrp1 (show SFRP1 Proteins) promotes cardiomyocyte differentiation in Xenopus via negative-feedback regulation of Wnt (show WNT2 Proteins) signalling.
analysis of differential role of Axin (show AXIN1 Proteins) RGS (show PITX2 Proteins) domain function in Wnt (show WNT2 Proteins) signaling during anteroposterior patterning and maternal axis formation
Data show taht combined Wnt (show WNT2 Proteins) and Nodal signaling synergistically activates transcription of Spemann organizer genes.
The authors propose that these dual functions of DP1 (show TFDP1 Proteins) can promote and stabilize biphasic Wnt (show WNT2 Proteins)-on and Wnt (show WNT2 Proteins)-off states in response to a gradual gradient of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling to determine differential cell fates.
These data suggested that Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway might be a potential target to treat the LPS (show TLR4 Proteins)-induced inflammation in ALI.
Wnt (show WNT2 Proteins) signaling regulates airway epithelial stem cells in adult murine submucosal glands.
Pax9 (show PAX9 Proteins)-dependent Wnt (show WNT2 Proteins) signaling has a role in palatogenesis and cleft palates
Data show that autocrine Wnt (show WNT2 Proteins) secretion is important for the survival, chromosomal stability, differentiation, and tumorigenic potential of embryonic stem cells (ESCs (show NR2E3 Proteins)).
Results demonstrated functional differences in the molecular mechanisms downstream of Wnt1 function in the diencephalon, in relation to the spinal cord. Wnt1 signal determines the patterning of the diencephalic dorso-ventral axis
Data show that both transgenic Wnt1-cre and P0-cre are similarly effective in deleting beta-catenin (show CTNNB1 Proteins) in the neural crest.
data suggest that WNT1-related osteogenesis imperfecta (show COL1A2 Proteins) and osteoporosis are caused in part by decreased mTORC1-dependent osteoblast function resulting from loss of WNT1 signaling in osteocytes.
Administration of EET alters Wnt1, NOV (show NOV Proteins), and HO-1 (show HMOX1 Proteins) signaling to prevent obesity-induced cardiomyopathy in obese mice.
Data indicate that Wnt1 proto-oncogene (show RAB1A Proteins) protein (WNT1) is the direct target of microRNA miR (show MLXIP Proteins)-34a in dendritic cell (DC).
In order to evaluate the function of IFT88 (show IFT88 Proteins) in regulating craniofacial development, we generated Wnt1-Cre;Ift88fl/fl mice to eliminate Ift88 (show IFT88 Proteins) specifically in cranial neural crest (CNC) cells. Wnt1-Cre;Ift88fl/flpups died at birth due to severe craniofacial defects including bilateral cleft lip and palate and tongue agenesis, following the loss of the primary cilia in the CNC-derived palatal mesenchyme
Vertebral compression fractures were present in 78% (7/9) of those aged over 50years but were not seen in younger mutation-positive subjects. All those with fractures had several severely compressed vertebrae. Altogether spinal compression fractures were present in 39% of those with a WNT1 mutation. Only
miR (show MLXIP Proteins)-218 promoted the apoptosis of human ovarian carcinoma cells via suppression of the WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway.
Data suggest that brain imaging be performed in any individual with WNT1-associated osteogenesis imperfecta (show COL1A2 Proteins) (OI) who also has developmental delay or any neurological deficits.
Data indicate a tetracyclic azafluorenone, SJ26, that is capable of binding to G-quadruplex DNA structure, repressing WNT1 expression, and inhibiting cell migration.
Regulation of WNT (show WNT2 Proteins) signaling by VSX2 (show VSX2 Proteins) during optic vesicle patterning in human induced pluripotent stem cells has been described.
High WNT1 expression is associated with metastasis in triple-negative breast cancer.
WNT1 osteoporosis causes significant skeletal changes already in early childhood and impairs bone mass gain during pubertal years.
High WNT1 expression is associated with esophageal squamous cell carcinoma.
High WNT1 expression in stromal cells is associated with myelodysplastic syndrome.
High WNT1 expression is associated with gastric cancer.
Data indicate that Wnt-1 protein is present in postdevelopmental endothelial cells where it associates with cytoskeletal elements and may retain function as a tissue polarity gene.
Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
wnt1 and wnt10b (show WNT10B Proteins) are required to maintain threshold levels of Pax2.1 and Fgf8 (show FGF8 Proteins) at the midbrain-hindbrain boundary.
novel role for Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling in determining endocardial cell fate
In zebrafish embryos lacking Wnt3a (show WNT3A Proteins), Wnt1 and Wnt10b (show WNT10B Proteins), the expression of engrailed orthologs, pax2a and fgf8 (show FGF8 Proteins) is not maintained after mid-somitogenesis
two Dvl (show DVL2 Proteins)-associated paralogs, Dpr1 (show DACT1 Proteins) and Dpr2 (show DACT2 Proteins), participate in distinct Wnt (show WNT2 Proteins)-dependent developmental processes
Wnt (show WNT2 Proteins)/Axin (show AXIN1 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway has a role in ventral CNS development
The boundary and roof plate expression of wnt1 each contribute to upregulation of proneural and delta gene expression and neurogenesis in non-boundary regions.
Epistatic analyses suggest a possible genetic interaction between Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and Myostatin (show MSTN Proteins) in regulation of slow and fast twitch muscle myofibrillogenesis
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.
, protein Wnt-1
, proto-oncogene Int-1
, proto-oncogene Wnt-1
, proto-oncogene protein Wnt-1
, proto-oncogene Int-1 homolog
, wingless-type MMTV integration site family, member 1 (oncogene INT1)
, Wingless-type MMTV integration site 1 homolog
, Wingless-type MMTV integration site 1, homolog
, wingless-related MMTV integration site 1
, murine mammary tumor virus integration site
, wingless-type MMTV integration site family member 1