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Human Monoclonal WNT16 Primary Antibody for WB - ABIN967363
Cadigan, Nusse: Wnt signaling: a common theme in animal development. in Genes & development 1998
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Rspo1 (show RSPO1 Antibodies) is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC (show FUT1 Antibodies) specification: Wnt16/DeltaC/DeltaD and Vegfa (show VEGFA Antibodies)/Tgfbeta1 (show TGFB1 Antibodies)
Wnt16 controls a novel genetic regulatory network required for HSC (show FUT1 Antibodies) specification
genomic analysis of conserved sequences between human, rat, and zebrafish WNT16
that WNT16 plays a critical role for acquisition of both cortical and trabecular bone mass and strength
WNT16 antagonises excessive canonical WNT (show WNT2 Antibodies) activation and protects cartilage in osteoarthritis.
Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone
Describe TGFbeta (show TGFB1 Antibodies)-Wnt16-Notch (show NOTCH1 Antibodies) signaling conduit in the chondrocyte-like transformation of VSMCs and identify endogenous TGFbeta (show TGFB1 Antibodies) activity in MGP (show MGP Antibodies)-null VSMCs as a critical mediator of chondrogenesis.
Wnt5a (show WNT5A Antibodies) abrogated the inhibitory effects of Wnt16 on Rankl (show TNFSF11 Antibodies)-induced osteoclastogenesis
These findings suggest that WNT16 acting via canonical WNT (show WNT2 Antibodies) signaling regulates mechanical strain-induced periosteal bone formation and bone size.
Osteoblast-derived WNT16 is a previously unreported key regulator of osteoclastogenesis and fracture susceptibility.
Wnt16 is involved in intramembranous ossification and suppresses osteoblast differentiation through the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway.
Study revealed new domains of expression for Wnt2 (show WNT2 Antibodies), Wnt2b (show WNT2B Antibodies), Wnt5b (show WNT5B Antibodies), Wnt6 (show WNT6 Antibodies), Wnt7b (show WNT7B Antibodies), Wnt9a (show WNT9A Antibodies), Wnt10a (show WNT10A Antibodies), Wnt10b (show WNT10B Antibodies), Wnt11 (show WNT11 Antibodies) and Wnt16, in the limb.
WNT16B recognizes cancer cell surface receptors including frizzled (FZD) 3 (show FZD3 Antibodies)/4/6, a process enhanced by SFRP2 (show SFRP2 Antibodies), coordinated by the co-receptor LRP6 (show LRP6 Antibodies) but subject to abrogation by DKK1 (show DKK1 Antibodies).
the upregulation of autophagy-related gene (Atg) and wingless/int1 (show WNT1 Antibodies) (Wnt (show WNT2 Antibodies)) signaling during BMP-2 (show BMP2 Antibodies)-mediated human osteoblastic differentiation, was examined.
PRKX (show PRKX Antibodies), WNT3 (show WNT3 Antibodies) and WNT16 genes, belonging to the WNT (show WNT2 Antibodies) signaling pathway, are involved in the tumorigenic process of nodular basal cell carcinoma
ThE findingS suggests that WNT16 might be an important genetic factor in determining peak bone mass acquisition.
Although in vitro studies demonstrated no differences in expressions of wild-type and mutant forms of IDUA (show IDUA Antibodies) and WNT16B proteins, in silico analyses predicts that WNT16 rs2707466 directly abolishes a phosphorylation site, which could cause a deleterious effect on WNT16 protein.
MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 (show AKT1 Antibodies) and Wnt-16
Data indicate that WNT16 is critical for positive regulation of both cortical and trabecular bone mass and structure. WNT16-TG mice exhibited significantly higher whole-body areal bone mineral density and bone mineral content.
ALL cells expressing WNT16 are sensitive to endoplasmic reticulum stress, and show enhanced killing after addition of chloroquine.
loss of endogenous WNT16 results specifically in cortical bone loss, whereas overexpression of WNT16 surprisingly increases mainly trabecular bone mass.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen.
wingless-type MMTV integration site family, member 16
, protein Wnt-16
, protein Wnt-16-like
, wingless-type MMTV integration site family member 16
, wingless-type MMTV integration site family member 16b
, wingless-related MMTV integration site 16