Browse our WNT2 Proteins (WNT2)

Full name:: Wingless-Type MMTV Integration Site Family Member 2 Proteins (WNT2)

On www.antibodies-online.com are 23 Wingless-Type MMTV Integration Site Family Member 2 (WNT2) Proteins from 6 different suppliers available. Additionally we are shipping WNT2 Antibodies (67) and WNT2 Kits (18) and many more products for this protein. A total of 116 WNT2 products are currently listed.

Synonyms:: 2610510E18Rik, CG1916, D-wnt-2, Dm-2, Dm DWnt2, Dmel\\CG1916, Dwnt-2, dWnt2, INT1L1, IRP, Mirp, Wnt, wnt-2, WNT2, Wnt2a, Xwnt-2, Xwnt2, ZfWnt2

list all proteins	Gene Name	GeneID	UniProt
Mouse WNT2	WNT2	22413	P21552
	WNT2	7472	P09544
Rat WNT2	WNT2	114487
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WNT2 Proteins (WNT2) by Origin

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Relevant Pathways for WNT2 Proteins

WNT Signaling

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Top referenced WNT2 Proteins

Human WNT2 Protein expressed in Wheat germ - ABIN1325356 : Habuchi, Nagai, Sugaya, Atsumi, Stevens, Kimata: Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality. in The Journal of biological chemistry 2007 (PubMed)
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More Proteins for WNT2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Wingless-Type MMTV Integration Site Family Member 2 (WNT2) interaction partners

We discovered an otk paralog (otk2, CG8964), which is co-expressed with otk throughout embryonic and larval development. Otk and Otk2 bind to each other and form complexes with Frizzled, Frizzled2 (show FZD2 Proteins) and Wnt2, pointing to a function as Wnt (show WNT4 Proteins) co-receptors.
Mutations in Wnt2 alter presynaptic motor neuron morphology and presynaptic protein localization at the neuromuscular junction.
DWnt-2 promotes correct patterning of direct flight muscles through a mechanism that is independent of the attachment site differentiation initiated by stripe.
Data show that Drosophila Naked cuticle (Nkd (show NKD1 Proteins)) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt (show WNT4 Proteins)/beta-catenin signaling.
It activates beta-catenin-independent pathway, such as planar cell polarity pathway, calcium signaling. (review)

Mouse (Murine) Wingless-Type MMTV Integration Site Family Member 2 (WNT2) interaction partners

Transient expression of WNT2 promotes somatic cell reprogramming by inducing beta-catenin (show CTNNB1 Proteins) nuclear accumulation.
Study indicates essential roles for Wnt2 and Wnt3 (show WNT3 Proteins) in chronic restraint stress-induced depression-like behaviors and antidepressant.
Upregulation of Wnt2 expression enhanced WISP-1 (show WISP1 Proteins) and promoted vascular smooth muscle cell migration and intimal thickening.
Wnt 2 levels were markedly down-regulated by retinoic acid in pancreatic stellar cells and chronic pancreatitis.
We propose that the WNT2/CTNNB1 (show CTNNB1 Proteins) pathway regulates CX43 (show GJA1 Proteins) expression and gap junction intercellular communication in granulosa cells by modulating CTNNB1 (show CTNNB1 Proteins) stability and localization in adherens junctions
Pdgf (show PDGFA Proteins) signaling potentiates Wnt2-Wnt7b (show WNT7B Proteins) signaling to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper development of endoderm-derived organs, such as the lung
Expression of WNT2 in pancreatic cancer cells suppresses anoikis, enhances anchorage-independent sphere formation, and increases metastatic propensity in vivo.
Wnt2 plays strong positive stage-specific role in cardiogenesis through non-canonical Wnt pathway in murine ES cells.
show that Wnt2 signaling is necessary and sufficient for activation of a transcriptional and signaling network critical for smooth muscle specification and differentiation including myocardin/Mrtf-B (show MKL2 Proteins) and the signaling factor Fgf10 (show FGF10 Proteins)
Wnt2 expression is downregulated at lung bud stage in the nitrofen model. Optical projection tomography is potentially a useful approach to visualize both gene expression and morphology during very early stages of lung development.

Human Wingless-Type MMTV Integration Site Family Member 2 (WNT2) interaction partners

WNT2 insufficiency might cause impaired trophoblast cell proliferation and migration via downregulation of Wnt/beta-catenin (show CTNNB1 Proteins) signaling pathway.
Three-dimensional organotypic co-culture assays revealed that WNT2-mediated fibroblast motility and extracellular matrix remodeling enhanced cancer cell invasion of cell lines even harboring mutations in the adenomatous polyposis coli (show APC Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
Chondrogenic potential was higher and Wnt/beta-catenin signaling was more potently activated by a GSK-3beta inhibitor in the posterior than in the anterior part of the human infant sclera.
data enforced the evidence that knockdown of c-Fos inhibited cell proliferation, migration, and invasion, and promoted the apoptosis of OS cells accompanied by altered expression of Wnt2 and Fzd9
High WNT2 expression is associated with Cervical Carcinoma Metastasis.
targeting beta-catenin with lipofection-delivered small interfering RNA oligonucleotide inhibited the proliferation and cell cycle arrest in G0/G1 phase and increased apoptosis of fibroblast cells, accompanied by downregulation of Wnt2 and cyclin D1 as well as the phosphorylation level of glycogen synthase kinase 3 beta in the keloid fibrosis
Genetic polymorphisms in the WNT2 and CTNNB1 genes were closely associated with hepatocellular carcinoma risk and progression in a Chinese Han population
The WNT2 rs39315 G allele was associated with advanced tumor stage in hepatocellular carcinoma.
Wnt2 complements Wnt/beta-catenin (show CTNNB1 Proteins) signaling in regulating colorectal cancer cell proliferation.
Wnt2/beta-catenin (show CTNNB1 Proteins) signaling was involved in stromal-epithelial cells interaction in endometriosis.

Cow (Bovine) Wingless-Type MMTV Integration Site Family Member 2 (WNT2) interaction partners

WNT2 gene is associated with resistance to paratuberculosis
These data demonstrate for the first time that FSH (show BRD2 Proteins) regulates CTNNB1 (show CTNNB1 Proteins) protein and WNT2 mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT signaling in ovarian steroidogenesis and follicular growth of cattle.

Zebrafish Wingless-Type MMTV Integration Site Family Member 2 (WNT2) interaction partners

show that sequential functions of Wnt2bb and Wnt2 control liver specification and proliferation in zebrafish

WNT2 Protein Profile

Protein Summary

This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene.

Alternative names and synonyms associated with WNT2

Wnt oncogene analog 2 (Wnt2)
Wnt family member 2 (wnt2)
Wnt family member 2 (WNT2)
wingless-type MMTV integration site family member 2 (Wnt2)
wingless-type MMTV integration site family member 2 (WNT2)
wingless-type MMTV integration site family, member 2 (Wnt2)
Wnt family member 2 (Wnt2)
wingless-type MMTV integration site family member 2 (wnt2)

2610510E18Rik protein
CG1916 protein
D-wnt-2 protein
Dm-2 protein
Dm DWnt2 protein
Dmel\\CG1916 protein
Dwnt-2 protein
dWnt2 protein
INT1L1 protein
IRP protein
Mirp protein
Wnt protein
wnt-2 protein
WNT2 protein
Wnt2a protein
Xwnt-2 protein
Xwnt2 protein
ZfWnt2 protein

Protein level used designations for WNT2

CG1916-PA , Wnt2-PA , wingless-type MMTV integration site family member 2 , INT-1-related protein , protein Wnt-2 , Int-1-related protein , int-1-like protein 1 , secreted growth factor , wingless-related MMTV integration site 2 , wingless-type MMTV integration site 2 , protein Wnt-2-like , Protein Wnt-2 , etID309852.18

GENE ID	SPECIES
35975	Drosophila melanogaster
100137508	Takifugu rubripes
100221216	Taeniopygia guttata
100303493	Saccoglossus kowalevskii
612141	Canis lupus familiaris
780953	Monodelphis domestica
100038261	Xenopus (Silurana) tropicalis
100125382	Sus scrofa
22413	Mus musculus
7472	Homo sapiens
114487	Rattus norvegicus
417769	Gallus gallus
493729	Bos taurus
493672	Felis catus
100056092	Equus caballus
100126569	Oryctolagus cuniculus
100126577	Ovis aries
100137034	Pongo abelii
100411308	Callithrix jacchus
463673	Pan troglodytes
30127	Danio rerio
101651785	Echinops telfairi

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Show all Wingless-Type MMTV Integration Site Family Member 2 Proteins (WNT2) with Pubmed References