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Human WNT2 Protein expressed in Wheat germ - ABIN1325356
Habuchi, Nagai, Sugaya, Atsumi, Stevens, Kimata: Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality. in The Journal of biological chemistry 2007
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We discovered an otk paralog (otk2, CG8964), which is co-expressed with otk throughout embryonic and larval development. Otk and Otk2 bind to each other and form complexes with Frizzled, Frizzled2 (show FZD2 Proteins) and Wnt2, pointing to a function as Wnt (show WNT4 Proteins) co-receptors.
Mutations in Wnt2 alter presynaptic motor neuron morphology and presynaptic protein localization at the neuromuscular junction.
DWnt-2 promotes correct patterning of direct flight muscles through a mechanism that is independent of the attachment site differentiation initiated by stripe.
Data show that Drosophila Naked cuticle (Nkd (show NKD1 Proteins)) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt (show WNT4 Proteins)/beta-catenin signaling.
It activates beta-catenin-independent pathway, such as planar cell polarity pathway, calcium signaling. (review)
Transient expression of WNT2 promotes somatic cell reprogramming by inducing beta-catenin (show CTNNB1 Proteins) nuclear accumulation.
Study indicates essential roles for Wnt2 and Wnt3 (show WNT3 Proteins) in chronic restraint stress-induced depression-like behaviors and antidepressant.
Upregulation of Wnt2 expression enhanced WISP-1 (show WISP1 Proteins) and promoted vascular smooth muscle cell migration and intimal thickening.
Wnt 2 levels were markedly down-regulated by retinoic acid in pancreatic stellar cells and chronic pancreatitis.
We propose that the WNT2/CTNNB1 (show CTNNB1 Proteins) pathway regulates CX43 (show GJA1 Proteins) expression and gap junction intercellular communication in granulosa cells by modulating CTNNB1 (show CTNNB1 Proteins) stability and localization in adherens junctions
Pdgf (show PDGFA Proteins) signaling potentiates Wnt2-Wnt7b (show WNT7B Proteins) signaling to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper development of endoderm-derived organs, such as the lung
Expression of WNT2 in pancreatic cancer cells suppresses anoikis, enhances anchorage-independent sphere formation, and increases metastatic propensity in vivo.
Wnt2 plays strong positive stage-specific role in cardiogenesis through non-canonical Wnt pathway in murine ES cells.
show that Wnt2 signaling is necessary and sufficient for activation of a transcriptional and signaling network critical for smooth muscle specification and differentiation including myocardin/Mrtf-B (show MKL2 Proteins) and the signaling factor Fgf10 (show FGF10 Proteins)
Wnt2 expression is downregulated at lung bud stage in the nitrofen model. Optical projection tomography is potentially a useful approach to visualize both gene expression and morphology during very early stages of lung development.
Down-regulation of miR (show MLXIP Proteins)-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway through inhibition of Wnt2 and Fzd2 (show FZD2 Proteins).
The data suggest that Med19 (show MED19 Proteins) expression correlates with aggressive characteristics of bladder cancer, and Med19 (show MED19 Proteins) knockdown suppresses the proliferation and migration of cancer cells through down-regulating the Wnt/beta-catenin (show CTNNB1 Proteins) pathway.
The findings of this study have shown that molecular mechanisms, including aberrant activation of the WNT2 gene signaling pathway, may be involved in the pathogenesis of preeclampsia.
SNPs in WNT2 and FOXP2 (show FOXP2 Proteins) are associated with clinical symptom severity of autism spectrum disorders.
WNT2 insufficiency might cause impaired trophoblast cell proliferation and migration via downregulation of Wnt/beta-catenin (show CTNNB1 Proteins) signaling pathway.
Three-dimensional organotypic co-culture assays revealed that WNT2-mediated fibroblast motility and extracellular matrix remodeling enhanced cancer cell invasion of cell lines even harboring mutations in the adenomatous polyposis coli (show APC Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.
Chondrogenic potential was higher and Wnt/beta-catenin signaling was more potently activated by a GSK-3beta inhibitor in the posterior than in the anterior part of the human infant sclera.
data enforced the evidence that knockdown of c-Fos inhibited cell proliferation, migration, and invasion, and promoted the apoptosis of OS cells accompanied by altered expression of Wnt2 and Fzd9
High WNT2 expression is associated with Cervical Carcinoma Metastasis.
targeting beta-catenin with lipofection-delivered small interfering RNA oligonucleotide inhibited the proliferation and cell cycle arrest in G0/G1 phase and increased apoptosis of fibroblast cells, accompanied by downregulation of Wnt2 and cyclin D1 as well as the phosphorylation level of glycogen synthase kinase 3 beta in the keloid fibrosis
WNT2 gene is associated with resistance to paratuberculosis
These data demonstrate for the first time that FSH (show BRD2 Proteins) regulates CTNNB1 (show CTNNB1 Proteins) protein and WNT2 mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT signaling in ovarian steroidogenesis and follicular growth of cattle.
show that sequential functions of Wnt2bb and Wnt2 control liver specification and proliferation in zebrafish
This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene.
, wingless-type MMTV integration site family member 2
, INT-1-related protein
, protein Wnt-2
, Int-1-related protein
, int-1-like protein 1
, secreted growth factor
, wingless-related MMTV integration site 2
, wingless-type MMTV integration site 2
, protein Wnt-2-like
, Protein Wnt-2