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Study results indicated that PLAGL2 was overexpressed in colorectal cancer (CRC) as a protooncogene and that it could active the Wnt/betacatenin pathway as a transcription factor by binding with the promoter region of Wnt6.
WNT6 may be a diagnostic and prognostic marker in osteosarcoma
our results support the concept that WNT6 may play a role in tumor progression
WNT6 activates the JNK signaling pathway in HDPCs, leading to migration and differentiation.
analysis of missense mutation in WNT6 in couples with unexplained recurrent miscarriage
WNT6 and Cav1 are upregulated by chemotherapeutics and enhance the resistance of GC cells to anthracycline drugs
The WNT6 rs6747776 homozygous minor allele (CC) was associated with increased risk of colorectal adenoma.
Wnt6 plays an important role in tooth development by promoting human dental papilla cell differentiation, without significant effects on cell proliferation.
Wnt6 signals through the canonical pathway in renal epithelial cells as evidenced by increased phosphorylation of GSK3beta ), nuclear accumulation of beta-catenin and increased TCF/Lef transcriptional activity
A negative feedback loop involving WNT6 and DKK1 attenuates canonical WNT6-beta-catenin signaling, thereby allowing teratocarcinoma cells to differentiate.
Sertoli cells secrete Wnt6 as a paracrine signal for undifferentiated spermatogonia.
A novel role of Sfrp2 and Wnt6 in regulating the dynamic process of CPC proliferation and differentiation.
Wnt6 is a novel factor driving macrophage polarization toward an M2-like phenotype. These findings point to an unexpected role for Wnt6 in macrophage differentiation in the M. tuberculosis-infected lung.
GATA6 and FOXA2 bind the Wnt6 promoter and regulate its activity, leading to primitive endoderm formation.
Mechanisms downstream of beta-catenin are required for Wnt6, Wnt10a and Wnt10b to influence differentiation of mesenchymal precursors.
The mRNA levels of Wnt3, 6, and 9a were significantly upregulated in the intestinal epithelial cells by Salmonella.
expressed in the ureter bud and induces kidney tubule development in vitro
Wnt6 is able to regulate the development of epithelial somites
Identify Wnt6-beta-catenin-Snail signalling cascade involved in epithelial-to-mesenchymal transitions in embryogenesis and metastasis.
Data show that WNT signaling through Wnt4, 5a and 6 affects gene expression in the ventral diencephalon and pituitary gland growth.
Study revealed new domains of expression for Wnt2, Wnt2b, Wnt5b, Wnt6, Wnt7b, Wnt9a, Wnt10a, Wnt10b, Wnt11 and Wnt16, in the limb.
study reports the localization within embryonic tissues of xWnt6 protein; together with the temporal and spatial expression of Xenopus laevis Wnt6 mRNA
Wnt6 is identified in Xenopus as an endogenous Wnt signal, which is expressed in tissues close to and later inside the developing heart.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level.
, wingless-related MMTV integration site 6
, WNT6 protein
, wingless-related MMTV integration site 6 homolog
, wingless-type MMTV integration site family, member 6
, wingless-type MMTV integration site family, member 6 a
, wnt-1 related (wnt-6), wingless-type MMTV integration site family