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experiments indicate that Reck and Gpr124 are part of the cell surface protein complex that transduces Wnt7a- and Wnt7b-specific signals in mammalian CNS epithelial cells to promote angiogenesis and regulate the BBB
Ptgs2 (show PTGS2 Proteins) inhibitor celecoxib reduces dsRNA-induced WIHN and Wnt7b, and exogenous prostaglandin E2 can rescue WIHN and Wnt7b. Although other Wnts and pathways likely contribute, these results highlight noncoding dsRNA as an upstream coordinator of prostaglandin and Wnt (show WNT2 Proteins) levels in regeneration.
the present study detected abnormal upregulation in the levels of Wnt2b (show WNT2B Proteins) and Wnt7b, and hypothesized that the alterations may be due to the ectopic opening of chromatin structure.
In a mouse model of myopia, there was downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.
Wnt7b is required for epithelial progenitor growth and operates during epithelial-to-mesenchymal signaling in pancreatic development.
Transgenic Wnt7b overexpression in neural progenitor cells impairs neuronal differentiation and the development of forebrain structures at embryonic day 10.5. It decreased expression of Tbr1 and Tbr2 (show EOMES Proteins), in both progenitor cells and post-mitotic neurons.
These findings demonstrate the importance of intrinsic Wnt7b expression in hfSCs regulation and normal HF cycling
Stable ectopic expression of Wnt-7b in OSCC cells overexpressing miR329 or miR410 restored proliferation and invasion capabilities abolished by these miRNA
Results illustrated the critical role of myeloid WNT7B in tumor progression, acting at the levels of angiogenesis, invasion, and metastasis.
epithelial Wnt7a (show WNT7A Proteins) and Wnt7b are possible ligands of Fzd-mediated beta-catenin (Ctnnb1 (show CTNNB1 Proteins))-dependent (canonical) Wnt (show WNT2 Proteins) signaling in the adjacent undifferentiated periotic mesenchyme of fibrocytes in the murine inner ear
In an examination of signaling pathways in developing Xenopus lung, wnt7b was expressed in the entire lung epithelium from stage 37 to stage 45.
Forced overexpression of Wnt7B with or without TGFB1 (show TGFB1 Proteins) treatment increased Wnt5A protein (show WNT5A Proteins) expression in normal human smooth muscle cells and fibroblasts but not in Idiopathic Pulmonary Fibrosis myofibroblasts where Wnt5A (show WNT5A Proteins) was already highly expressed.
WNT7B as a novel susceptibility gene for axial length and corneal curvature and is associated with myopia and extreme myopia.
Results suggest that AR-regulated WNT7B signaling is critical for the growth of CRPC and development of the osteoblastic bone response characteristic of advanced prostate cancer.
WNT7B can serve as a primary determinant of differential Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) activation in pancreatic adenocarcinoma.
Wnt7B was expressed at high concentrations in regions of active hyperplasia, metaplasia, and fibrotic change in idiopathic pulmonary fibrosis patients.
Pdgf (show PDGFA Proteins) signaling potentiates Wnt2 (show WNT2 Proteins)-Wnt7b signaling to promote high levels of Wnt (show WNT2 Proteins) activity in mesenchymal progenitors that is required for proper development of endoderm-derived organs, such as the lung
Results demonstrated significant up-regulation of WNT-3 (show WNT3 Proteins), WNT-4 (show WNT4 Proteins), WNT-5B (show WNT5B Proteins), WNT-7B, WNT-9A (show WNT9A Proteins), WNT-10A (show WNT10A Proteins), and WNT (show WNT2 Proteins)-16B in patients with CLL compared to normal subjects.
These data demonstrate that mesenchymal stem cells from mice and humans produce Wnt (show WNT2 Proteins) proteins and TGF-beta1 (show TGFB1 Proteins) that respectively stimulate lung fibroblast proliferation and matrix production.
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein.
wingless-type MMTV integration site family, member 7B
, wingless-type MMTV integration site family, member 7
, protein Wnt-7b-like
, protein Wnt-7b
, wingless-related MMTV integration site 7B