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Our study further supports the involvement of WNT9B as a cleft susceptibility gene in Brazilian families experiencing NSCL (show NHLH1 Proteins)+/-P. Although additional studies are still necessary to unveil the exact mechanism by which WNT (show WNT2 Proteins) genes would contribute to NSCL (show NHLH1 Proteins)+/-P, allelic polymorphisms in these genes and their interactions may partly explain the variance of individual susceptibility to NSCL (show NHLH1 Proteins)+/-P.
Multi-layered mutation in hedgehog (show SHH Proteins)-related genes in Gorlin syndrome may affect the phenotype
This association study successfully identified two susceptibility Single Nucleotide Polymorphisms, (WNT9B and PBX1 (show PBX1 Proteins)) associated with Mayer-Rokitansky-Kuster-Hauser syndrome risk, both separately and interactively.
Genome association study shows a highly conserved 32 kb intergenic region containing regulatory elements between WNT3 (show WNT3 Proteins) and WNT9B in patients with classic bladder exstrophy.
results indicate that mutations in the coding sequence of WNT9B are not responsible for Mullerian duct abnormalities in the Chinese population
Two novel mutations (a missense mutation in exon 1, and one in the 3-UTR) may be pathogenic variants in Mayer-Rokitansky-Kuster-Hauser syndrome patients and warrant further functional study.
secretion of WNT2B (show WNT2B Proteins) and WNT9B and stabilization of beta-catenin (CTNNB1 (show CTNNB1 Proteins)) upon virus infection negatively regulate expression of representative inducible genes IFNB1 (show IFNB1 Proteins), IFIT1 (show IFIT1 Proteins) and TNF (show TNF Proteins) in a CTNNB1 (show CTNNB1 Proteins)-dependent effector mechanism
The signals from the stromal fibroblasts cooperate with Wnt9b to promote differentiation of the progenitor cells.
Mutations in the coding sequence of WNT4 (show WNT4 Proteins), WNT5A (show WNT5A Proteins), WNT7A (show WNT7A Proteins), and WNT9B are not responsible for the Mayer-Rokitansky-Kuster-Hauser syndrome.
These analyses suggest that in zebrafish, as in humans, wnt9b plays distinct roles in directing morphogenetic movements of developing branchial arch elements.
Data indicate that mutations in wingless-type MMTV integration site family, member 9B protein (WNT9B) were frequently associated with Mayer-Rokitansky-Kuster-Hauser syndrome (MRKHS).
Epigenetic mechanism causes Wnt9b deficiency and nonsyndromic cleft lip and palate in the A/WySn mouse strain.
Expression of Wnt9b in Six2 (show SIX2 Proteins)-positive cells disrupts cell fate decisions in the kidney and the gastrointestinal tract.
Epithelial Wnt7b (show WNT7B Proteins) and Wnt9b as possible ligands of Fzd1 (show Fzd1 Proteins)-mediated beta-catenin (Ctnnb1 (show CTNNB1 Proteins))-dependent (canonical) Wnt (show WNT2 Proteins) signaling in the undifferentiated ureteric mesenchyme
Study has identified a previously unknown regulatory link between WNT9B and FGF signaling during lip and upper jaw development.
Notch (show NOTCH1 Proteins) pathway activation can replace the requirement for Wnt4 (show WNT4 Proteins) and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells
wnt9b signaling regulates stem cell proliferation and differention in the developing kidney depending on the activity of the transcription factor Six2 (show SIX2 Proteins) in the responding cell.
transgenic overexpression of Wnt9b in the ureteric bud causes reduced branching in multiple founder lines.
expression in most but not all tissues of the 16.5-day embryo; no significant elevation of Wnt9b expression was detected in 29 mouse mammary tumor virus-induced tumors
Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system.
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).
, protein Wnt-9b
, wingless-type MMTV integration site family, member 15
, wnt9b protein
, wingless related MMTV integration site 9B
, wingless-type MMTV integration site 9B
, wingless-type MMTV integration site family, member 9B
, wingless-type MMTV integration site 15