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anti-Ataxin 2 (ATXN2) Antibodies

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Additionally we are shipping Ataxin 2 Kits (28) and Ataxin 2 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ATXN2 6311 Q99700
ATXN2 20239 O70305
ATXN2 288663  
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Top anti-Ataxin 2 Antibodies at antibodies-online.com

Showing 10 out of 58 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ATXN2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HepG2/Jurkat/293 cells, using A... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Mouse Un-conjugated IF, WB Western blot analysis of Ataxin-2 on Jurkat cell lysate (left). Lane 1... Immunofluorescent staining of SH-SY5Y cells (right). Cells were seeded... 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- ATX2 Picoband antibody, IHC(P) IHC(P): Rat Brain Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB Anti-ATX2 antibody, Western blotting Lane 1: PANC Cell Lysate Lane 2: ... 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse embryo tissue labeled withA... Formalin-fixed and paraffin embedded rat brain tissue labeled with Ant... 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Goat Un-conjugated ELISA 50 μg Log in to see 8 to 10 Days
$419.83
Details
Human Rabbit Un-conjugated IP, IHC, WB Immunohistochemical analysis of Ataxin 2 staining in human breast canc... Western blot analysis of Ataxin 2 expression in HeLa (A), U87MG (B), J... 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details

ATXN2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Rat (Rattus) , , , ,
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Top referenced anti-Ataxin 2 Antibodies

  1. Human Monoclonal Ataxin 2 Primary Antibody for IF, WB - ABIN968504 : Huynh, Del Bigio, Ho, Pulst: Expression of ataxin-2 in brains from normal individuals and patients with Alzheimer's disease and spinocerebellar ataxia 2. in Annals of neurology 1999 (PubMed)
    Show all 3 references for ABIN968504

  2. Cow (Bovine) Polyclonal Ataxin 2 Primary Antibody for WB - ABIN2780458 : Ragothaman, Muthane: Homozygous SCA 2 mutations changes phenotype and hastens progression. in Movement disorders : official journal of the Movement Disorder Society 2008 (PubMed)

  3. Human Polyclonal Ataxin 2 Primary Antibody for ELISA, WB - ABIN1534657 : Sahba, Nechiporuk, Figueroa, Nechiporuk, Pulst: Genomic structure of the human gene for spinocerebellar ataxia type 2 (SCA2) on chromosome 12q24.1. in Genomics 1998 (PubMed)

More Antibodies against Ataxin 2 Interaction Partners

Human Ataxin 2 (ATXN2) interaction partners

  1. Selective loss of Purkinje cells in the cerebellar vermis of amyotrophic lateral sclerosis cases with intermediate repeat expansions in the ATXN2 gene.

  2. A meta-analysis of the top SNPs identified three new associated loci in primary open angle glaucoma--TXNRD2 (show TXNRD2 Antibodies), ATXN2, and FOXC1 (show FOXC1 Antibodies)

  3. Data suggest that the spinocerebellar ataxia 2 protein (ATXN2, SCA2) CAG/CAA repeat expansion may play an important role in the phenotypic variability of Parkinson's disease.

  4. ATXN2 is a modifier of phenotype in ALS patients of Sardinian ancestry.(

  5. FBXW8 (show FBXW8 Antibodies) and PARK2 (show PARK2 Antibodies) are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 (show FBXW8 Antibodies) expression is dysregulated

  6. This is the first description of a family with two SCA mutations with affected subjects having a combined SCA2 (show LY6E Antibodies) and SCA10 (show ATXN10 Antibodies) phenotype.

  7. ATXN2 intermediate-length polyglutamine expansions greater than 24 and 27 repeats were associated with sporadic ALS.

  8. ATXN2 CAG expansion is the sole causative mutation responsible for parkinsonian phenotype of spinocerebellar ataxia (show USP14 Antibodies)-2.

  9. results indicate presence of intermediate CAG repeat (show CELF3 Antibodies) expansion in the ATXN2 gene is a specific genetic risk factor for amyotrophic lateral sclerosis [review, meta-anlysis]

  10. Review of the role of epigenetics and the ATXN2 gene in spinocerebellar ataxia (show USP14 Antibodies) 2 and amyotrophic lateral sclerosis.

Mouse (Murine) Ataxin 2 (ATXN2) interaction partners

  1. work suggests that in Machado-Joseph disease, mutant ataxin-3 (show ATXN3 Antibodies) drives an abnormal reduction of ataxin-2 levels, which overactivates poly(A)-binding protein, increases translation of mutant ataxin-3 (show ATXN3 Antibodies) and other proteins and aggravates Machado-Joseph disease.

  2. ATXN2 interacted selectively with RGS8 (show RGS8 Antibodies) mRNA. This interaction was impaired when ATXN2 harbored an expanded polyglutamine. Mutant ATXN2 also reduced RGS8 (show RGS8 Antibodies) expression in an in vitro coupled translation

  3. The physiological role of ATXN2 subtly modifies the abundance of cellular translation factors as well as global translation.

  4. FBXW8 (show FBXW8 Antibodies) and PARK2 (show PARK2 Antibodies) are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 (show FBXW8 Antibodies) expression is dysregulated

  5. In KO mice, ATXN2 deficiency alters steady-state levels of Grb2 and Src, but does not block Grb2-dependent Ras signaling.

  6. our data support the concept that expanded ATXN2 undergoes progressive insolubility and affects PABPC1 (show PABPC1 Antibodies) by a toxic gain-of-function mechanism with tissue-specific effects, which may be partially alleviated by the induction of FBXW8 (show FBXW8 Antibodies).

  7. Ataxin-2 is not essential in development or during adult survival in the mouse, but leads to adult-onset obesity.

  8. In analyses up to the age of 6 months, the ataxin-2 deficient mouse showed abdominal obesity and hepatosteatosis and this was associated with reduced insulin receptor (show INSR Antibodies) expression in liver and cerebellum.

  9. These data implicate ataxin-2 to play a role in endocytic receptor cycling.

  10. results suggest that Atxn2-deficiency results in a specific set of behavioral and cellular disturbances that include motor hyperactivity and abnormal fear-related behaviors, but intact hippocampal function

Ataxin 2 (ATXN2) Antigen Profile

Protein Summary

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. This locus has been mapped to chromosome 12, and it has been determined that the diseased allele contains 37-50 CAG repeats, compared to 17-29 in the normal allele. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined.

Gene names and symbols associated with anti-Ataxin 2 (ATXN2) Antibodies

  • ataxin 2 (ATXN2) antibody
  • ataxin 2 (atxn2) antibody
  • ataxin 2 (Atxn2) antibody
  • ataxin 2-like (ATXN2L) antibody
  • 9630045M23Rik antibody
  • ASL13 antibody
  • ATX2 antibody
  • ATXN2 antibody
  • AW544490 antibody
  • MGC115230 antibody
  • Sca2 antibody
  • TNRC13 antibody

Protein level used designations for anti-Ataxin 2 (ATXN2) Antibodies

ataxin 2 , ataxin-2-like , ataxin-2 , spinocerebellar ataxia type 2 protein , trinucleotide repeat containing 13 , trinucleotide repeat-containing gene 13 protein , spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2) , spinocerebellar ataxia 2 homolog , spinocerebellar ataxia type 2 protein homolog , ataxin-2-like protein-like

GENE ID SPECIES
452247 Pan troglodytes
734531 Xenopus laevis
100017952 Monodelphis domestica
100057794 Equus caballus
100410598 Callithrix jacchus
6311 Homo sapiens
20239 Mus musculus
288663 Rattus norvegicus
486270 Canis lupus familiaris
532649 Bos taurus
100153708 Sus scrofa
100729317 Cavia porcellus
416877 Gallus gallus
101106796 Ovis aries
489951 Canis lupus familiaris
100515946 Sus scrofa
Selected quality suppliers for anti-Ataxin 2 (ATXN2) Antibodies
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