Rockland ModDetect™ Panels

Rockland's ModDetect™ panels are ready-to-use, immunoassay-based alternatives which facilitate the detection of specific chemical modifications independent of the sequence or location of the modification and can be used to evaluate a variety of RNA Tx modalities and nucleic acid structures. They provide robust detection and localization of oligonucleotide therapeutic drug delivery, thereby facilitating the collection of ADME analytical data for regulatory approval. The universal nature and unique specificity and sensitivity of these reagents eliminates the need for unique probes and accelerates candidate triage for a cost-effective, low-risk solution that can save 9-12 months in drug development.

Advantages of ModDetect™ Panels

ModDetect™ panels comprise monoclonal antibody reagents directed against nucleic acid backbones or sugar modifications in a sequence-independent manner, with each panel designed for a specific chemical modification. These antibodies offer sensitive and versatile tools for visualization, quantification, and detection across established immunoassays such as ELISA, immunocytochemistry (ICC) or immunohistochemistry (IHC). They enable the detection of ASO, siRNA, and mRNA molecules with diverse sequences but shared chemical modifications. Reagents can be applied individually or in multiplex formats in accordance with the recommended protocols. For a detailed overview of the methodology and application workflows, download the full application guide here.

• Time Saving
  Save 9-12 months in drug development with faster candidate triage
• Less Risk
  Evaluate multiple uniquely-specific reagents simultaneously in various immunoassays
• Cost Saving
  Eliminate the need for custom antibody development

ModDetect™ Phosphorothioate (PS) Panel (ABIN7675637)

Detect PS-modified oligonucleotides with confidence—independent of sequence. The ModDetect™ Phosphorothioate (PS) Panel targets the PS backbone directly, enabling robust detection across diverse oligonucleotide designs. Ideal for overcoming limitations of sequence-specific assays, it integrates seamlessly into ELISA, immunofluorescence, and tissue-based workflows. Accelerate biodistribution, localization, and quantitative studies in your research and preclinical development.
Learn more

ModDetect™ Phosphorothioate (PS) Biotinylated Panel (ABIN7675638)

Flexible detection for PS-modified oligonucleotides in advanced assay formats. This biotinylated panel combines sequence-independent PS recognition with streamlined integration into sandwich ELISAs and streptavidin-based workflows. Designed for reliable capture and quantification, it enables scalable and comparative bioanalysis across oligonucleotide therapeutics.
Learn more

ModDetect™ 2′-O-Methoxyethyl (MOE) Panel (ABIN7675639)

Unlock reliable detection of MOE-modified oligonucleotides—without sequence constraints. By targeting the MOE modification directly, this panel enables consistent analysis where conventional methods fall short. Compatible with ELISA, immunofluorescence, and tissue-based assays, it supports high-confidence biodistribution, localization, and quantitative evaluation in research and preclinical workflows.
Learn more

ModDetect™ 2′-O-Methoxyethyl (MOE) Biotinylated Panel (ABIN7675640)

Expand your assay flexibility with biotin-enabled MOE detection. This panel retains precise, sequence-independent recognition of MOE-modified oligonucleotides while enabling efficient integration into sandwich ELISAs and streptavidin-driven platforms. Optimized for robust quantification and comparative studies in demanding bioanalytical workflows.
Learn more

ModDetect™ 2′-O-Methyl (OMe) Panel (ABIN7675641)

Simplify detection of OMe-modified oligonucleotides across modalities. By directly targeting the OMe modification, this panel eliminates dependence on sequence-specific assays and enables consistent evaluation across diverse designs. Fully compatible with ELISA, immunofluorescence, and tissue-based applications, it supports distribution, localization, and performance studies with confidence.
Learn more

Subcellular Marker for Localizations Studies

Complement your ModDetect™ panels with validated subcellular markers from antibodies-online to strengthen data interpretation and experimental control. Incorporating compartment-specific markers enables precise localization of modified targets and helps confirm fractionation efficiency or cellular distribution. This combined approach enhances confidence in detecting post-translational modifications within defined cellular contexts. Explore our curated selection of subcellular markers to extend the analytical power of your ModDetect™ workflows.