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The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. Additionally we are shipping AXIN2 Kits (29) and AXIN2 Proteins (9) and many more products for this protein.
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Human Polyclonal AXIN2 Primary Antibody for EIA, WB - ABIN783373
Katoh, Katoh: WNT signaling pathway and stem cell signaling network. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Show all 2 references for ABIN783373
Genetic variant in AXIN2 gene is associated with gallbladder cancer.
Data show that SS18 (show SS18 Antibodies)/SSX (show SSX2 Antibodies) tightly regulates the elevated expression of the key Wnt (show WNT2 Antibodies) target AXIN2 in primary synovial sarcoma.
our mutation analysis detected already known mutations as well as, to the best of our knowledge, mutations and an interstitial deletion of CTNNB1 (show CTNNB1 Antibodies) not described in JAs (show TAP2 Antibodies) before. Additionally, a so far unknown transcribed Axin2 splice variant was found, but no further Axin2 mutations.
miR (show MLXIP Antibodies)-374a functions as an oncogene (show RAB1A Antibodies) in osteosarcoma, and the miR (show MLXIP Antibodies)-374a/Axin2 axis might represent a potential therapeutic target for OS intervention.
Flow cytometrically sorted CA9 (show CA9 Antibodies)+ population showed increased mRNA level of a Wnt (show WNT2 Antibodies) signaling factor AXIN2. In conclusion, these observations indicate that CA9 (show CA9 Antibodies) expression in normal crypt base cells has association with intestinal epithelial stemness
Increase in AXIN2 level expression is associated with breast cancer.
rs9675316 located on chr17q23-a24 (show CD164 Antibodies) near the AXIN2 gene was the most significantly associated with hallux valgus in males in genome-wide association meta-analyses.
Low AXIN2 was independently associated with more aggressive Prostate cancer , biochemical recurrence, and metastasis-free survival after Prostatectomies .
Axin2, a tumor suppressor, exhibited a marked inhibitory effect on Eca109 cell growth. The results identified a new role of miR (show MLXIP Antibodies)-374a in esophageal cancer involving Axin2 suppression
study supports the relationship between AXIN2 mutation and non-syndromic oligodontia and extends the mutation spectrum of the AXIN2 gene.
beta-catenin1 cannot revert the ich (show ACE Antibodies) phenotype because it may be under the control of a GSK3beta (show GSK3b Antibodies)-independent mechanism that required Axin's RGS (show PITX2 Antibodies) domain function.
The role of Axin-2 signaling in the proliferation of undifferentiated spermatogonia in the adult mouse testis
Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.
Axin2-expressing prostatic cells express epithelial cell markers and are able to expand cell lineage during prostatic development and maturation.
Axin1 (show AXIN1 Antibodies) and Axin2 do not have equivalent functions in satellite cells, but are both involved in repression of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signalling to maintain proliferation and contribute to controlling timely myogenic differentiation.
These data demonstrate a dominant role for Runx2 (show RUNX2 Antibodies) in chondrocyte maturation, but implicate Axin2 as an important modulator of the terminal stages of endochondral bone formation.
implants lacking primary stability undergo osseointegration, provided Wnt (show WNT2 Antibodies) signalling is amplified. Fibrous encapsulation can be prevented and osseointegration assured if Wnt (show WNT2 Antibodies) signalling is elevated at the time of implant placement.
Axin2(-/-) PF-sutures lack physiological endochondral ossification
Axin2(+) cells can give rise to spatially and functionally restricted populations of adult neural stem cells in the subventricular zone.
Axin2-positive tympanic border cells are Wnt (show WNT2 Antibodies) responsive and can act as precursors to sensory epithelial cells in the postnatal cochlea.
Runx2 (show RUNX2 Antibodies) protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
axin 2 (conductin, axil)
, axin-related protein
, axin 2
, Axin-related protein
, axin-like protein
, axis inhibition protein 2