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The protein encoded by CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. Additionally we are shipping CD70 Antibodies (187) and CD70 Kits (16) and many more products for this protein.
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Human CD70 Protein expressed in HEK-293 Cells - ABIN2713767
Mazor, Hansen, Yang, Chowdhury, Wang, Stephens, Wu, DallAcqua: Insights into the molecular basis of a bispecific antibody's target selectivity. in mAbs 2015
these findings demonstrate for the first time, to our knowledge, that T cell-derived CD70 plays a novel immune checkpoint role in inhibiting inflammatory T cell responses
findings demonstrate that host CD70 serves as a unique negative regulator of allogeneic T cell response by contributing to donor T cell apoptosis and inhibiting expansion of donor effector T cells.
CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27 (show CD27 Proteins)-expressing B-cell malignancies.
Mice lacking CD70 did not accumulate memory T cells and did not develop hypertension.
find that while stimulation of CD27 (show CD27 Proteins) in isolation drives weak Eomesodermin (show EOMES Proteins)(hi) T-bet(lo) CD8 (show CD8A Proteins)(+) T-cell responses to OVA immunization
Data show that although CD70 is required for the activation of the antiviral adaptive response, it has a regulatory role in early cytokine responses to viruses such as MCMV, possibly through maintenance of Treg survival and function.
the ability of CD70 to trigger costimulation is self-regulated when it binds its complementary receptor.
under conditions of constitutive CD70 expression reflecting chronic immune activation, the CD27 (show CD27 Proteins)/CD70 system inhibits OC differentiation and favors DC differentiation
mTECs and DCs form dedicated niches in the thymic medulla, in which CD27 (show CD27 Proteins)-CD70 co-stimulation rescues developing Treg cells from apoptosis, subsequent to Foxp3 (show FOXP3 Proteins) induction by TCR and CD28 (show CD28 Proteins) signals.
Expression of CD70 by B cells aggravates experimental autoimmune encephalomyelitis by reducing the number of regulatory T cells.
This study demonstrated that Expression of CD70 (CD27L) Is Associated With Epithelioid and Sarcomatous Features in IDH (show IDH1 Proteins)-Wild-Type Glioblastoma.
CD27 (show CD27 Proteins) is engaged by CD70 cross-presented by other AML (show RUNX1 Proteins) blasts or stem/progenitor cells in a paracrine manner.
the CD70-CD27 (show CD27 Proteins) pathway appears to be a crucial component of EBV-specific T cell immunity and more generally for the immune surveillance of B cells and may be a target for immunotherapy of B cell malignancies.
human CD70-CD27 (show CD27 Proteins) interactions therefore play a nonredundant role in T and B cell-mediated immunity, especially for protection against EBV and humoral immunity.
These data demonstrate the important role of the CD70/CD27 (show CD27 Proteins) axis in immune responses in HTLV-1 carriers and ATL patients.
CD70: An emerging target in cancer immunotherapy
Both monomeric and trimeric forms of CD70 were detected in tumour cell membrane fractions, whereas cytoplasmic fractions contained almost exclusively monomeric CD70
CD70 is overexpressed in systemic lupus erythematosus CD4 (show CD4 Proteins)+ T cells, but expression is not linked to the typical clinical and serological parameters associated with the disease.
CD70-blocking of alphaDC1s from both controls and patients with chronic lymphocytic leukaemia had a negative influence on the production of both IL-12p70 and the Th1 (show TH1L Proteins) cytokine IFN-gamma (show IFNG Proteins).
These results highlight the importance of the CD27 (show CD27 Proteins)-CD70 costimulation pathway for the development of CMV-specific T cell immunity during acute and persistent infection.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
, Ki-24 antigen
, tumor necrosis factor (ligand) superfamily, member 7
, tumor necrosis factor ligand superfamily member 7
, CD70 antigen
, surface antigen CD70