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Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. Additionally we are shipping CENPA Kits (21) and CENPA Proteins (20) and many more products for this protein.
Showing 10 out of 136 products:
Human Monoclonal CENPA Primary Antibody for ELISA - ABIN394040
Carroll, Milks, Straight: Dual recognition of CENP-A nucleosomes is required for centromere assembly. in The Journal of cell biology 2010
Show all 5 references for ABIN394040
Human Monoclonal CENPA Primary Antibody for WB - ABIN1027707
Rieder, Salmon: The vertebrate cell kinetochore and its roles during mitosis. in Trends in cell biology 1998
Show all 4 references for ABIN1027707
Human Polyclonal CENPA Primary Antibody for WB - ABIN657764
Sekulic, Bassett, Rogers, Black: The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres. in Nature 2010
Show all 2 references for ABIN657764
Human Polyclonal CENPA Primary Antibody for IHC, ELISA - ABIN1534330
Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005
Human Polyclonal CENPA Primary Antibody for IHC, WB - ABIN2782448
Black, Foltz, Chakravarthy, Luger, Woods, Cleveland: Structural determinants for generating centromeric chromatin. in Nature 2004
Human Polyclonal CENPA Primary Antibody for DB, ICC - ABIN2668362
Logsdon, Barrey, Bassett, DeNizio, Guo, Panchenko, Dawicki-McKenna, Heun, Black: Both tails and the centromere targeting domain of CENP-A are required for centromere establishment. in The Journal of cell biology 2015
Cow (Bovine) Polyclonal CENPA Primary Antibody for WB - ABIN2782449
Orthaus, Biskup, Hoffmann, Hoischen, Ohndorf, Benndorf, Diekmann: Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells. in Chembiochem : a European journal of chemical biology 2007
centromere assembly factors CAL1 (show CALCA Antibodies) and CENP-C are required for meiotic chromosome segregation, CENP-A assembly and maintenance on sperm, as well as fertility
identify two co-evolving regions, CENP-A L1 and the CAL1 (show CALCA Antibodies) N terminus, as critical for lineage-specific CENP-A incorporation
A novel role has been described for the histone acetyltransferase (show HAT Antibodies) Hat1 (show HAT1 Antibodies) in the CENP-A/CID assembly pathway in Drosophila melanogaster.
CENP-A assembly by its loading factor, CAL1, requires RNAPII-mediated transcription of the underlying DNA
The amount of Cid that is loaded during each cell cycle appears to be determined primarily by the preexisting centromeric Cid, with little flexibility for compensation of accidental losses.
CID nucleosomes are octameric in vivo and that CID dimerization is essential for correct centromere assembly.
The F box protein (show FBXO30 Antibodies) partner of paired (Ppa (show FBXL14 Antibodies)) mediates CenH3(CID) stability in Drosophila. Ppa (show FBXL14 Antibodies) depletion results in increased CenH3(CID) levels. Ppa (show FBXL14 Antibodies) physically interacts with CenH3(CID) through the CATD (show CTSD Antibodies)(CID) that mediates Ppa (show FBXL14 Antibodies)-dependent CenH3(CID) stability.
Drosophila CENP-C is essential for centromere identity.
Cid allows for contacts betwen DNA and histones and specific targeting
Results suggest that CID mislocalization promotes formation of ectopic centromeres and multicentric chromosomes, which causes chromosome missegregation, aneuploidy, and growth defects.
CENP-C (show CENPC1 Antibodies) and CENP-I (show CENPI Antibodies) are key factors connecting kinetochore to CENP-A assembly.
The authors found that the nucleosome shape change directed by CENP-A is dominated by lateral passing of two DNA gyres (gyre sliding).
the CRL4 complex containing RBBP7 (show RBBP7 Antibodies) (CRL4(RBBP7 (show RBBP7 Antibodies))) might regulate mitosis by promoting ubiquitin-dependent loading of newly synthesized CENP-A during the G1 phase of the cell cycle.
The DNA ends of the CENP-A nucleosome are more flexible than those of the H3 nucleosome.
We used a synthetic system to dissect how CenH3(CENP-A) contributes to the accumulation of CENP-C (show CENPC1 Antibodies) and CENP-T (show CENPT Antibodies), two key components that are necessary for the formation of functional kinetochores
The CENP-A/histone H3.3 (show H3F3A Antibodies) nucleosome forms an unexpectedly stable structure and allows the binding of the essential centromeric protein, CENP-C (show CENPC1 Antibodies), which is ectopically mislocalized in the chromosomes of CENP-A overexpressing tumor cells.
CENP-B (show CENPB Antibodies) directly binds both CENP-A's amino-terminal tail and CENP-C (show CENPC1 Antibodies), a key nucleator of kinetochore assembly
CENP-C (show CENPC1 Antibodies) depletion leads to rapid removal of CENP-A from centromeres, indicating their collaboration in maintaining centromere identity.
The study describes a novel function for human centromeric long non-coding RNAs in the recruitment of HJURP (show HJURP Antibodies) and CENP-A, implicating RNA-based chaperone targeting in histone variant assembly.
results indicate that the regions of CENP-A required for early events in centromere establishment differ from those that are required for maintaining centromere identity.
CPCs maintain relatively high levels of CENP-A early in life, which is necessary for sustaining proliferation, inhibiting senescence, and promoting survival following differentiation of CPCs.
Results report that the level of CENP-A, a protein required for cell division, declines precipitously with age in an islet-specific manner.
Cenpa, Cenpb (show CENPB Antibodies), and Bub3 (show BUB3 Antibodies), but not Cenpc (show CENPC1 Antibodies), interacted with PARP-1 (show PARP1 Antibodies)
The centromere-targeting domain of CENP-A is both necessary and sufficient for recruitment to double-strand breaks. CENP-A accumulation at DNA breaks is enhanced by active non-homologous end-joining but does not require DNA-PKcs (show PRKDC Antibodies) or Ligase IV.
CENP-A assembly into chromatin requires unidentified deoxycytidine deaminase (show APOBEC3G Antibodies) and UNG2 (show CCNO Antibodies), a uracil DNA glycosylase (show UNG Antibodies).
CENP-A deposition at the centromeres is dependent on HJURP (show HJURP Antibodies).
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
, centromere identifier protein
, centromere protein A
, centromere protein-A
, centromere protein, Xenopus
, histone H3-like centromeric protein A
, centromeric histone-3 like protein
, centromere autoantigen A
, centromere protein A, 17kDa
, centromere-specific histone
, centrosomin A