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anti-Centromere Protein A (CENPA) Antibodies

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. Additionally we are shipping CENPA Kits (21) and CENPA Proteins (20) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CENPA 1058 P49450
CENPA 12615 O35216
CENPA 298850  
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Top anti-CENPA Antibodies at

Showing 10 out of 136 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CENPA Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Hela cell lysate Host: Rabbit  Target Name: CENPA  Sample Tissue: 721_B  Antibody Dilution: 1.0 µg/mL CENPA is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB CENPA Antibody (Center) (ABIN657764) western blot analysis in Jurkat cell line lysates (35 µg/lane). This demonstrates the CENPA antibody detected the CENPA protein (arrow). 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using CENPA Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Human Mouse Un-conjugated WB CENP A U2OS lysate 1 in 1000. 100 μg Log in to see 3 to 4 Days
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged CENPA is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
Human Rabbit Un-conjugated DB, ICC, IF, WB CENP-A phospho Ser18 antibody (pAb) tested by dot blot analysis. Dot blot analysis was used to confirm the specificity of CENP-A phospho Ser18 antibody. Peptides corresponding to the immunogen and related proteins were spotted onto PVDF and probed with the antibody at 1:750. The amount of peptide (picomoles) spotted is indicated next to each row. Lane 1: CENP-A phospho Ser 16 and phospho Ser18. Lane 2: CENP-A unmodified. Lane 3: CENP-A phospho Ser 16. Lane 4: CENP-A phospho Ser 18. CENP-A phospho Ser18 antibody (pAb) tested by immunofluorescence. Detection of CENP-A phospho Ser18 by immunofluorescence. HeLa cells were stained with CENP-A phospho Ser18 antibody at a 1:100 dilution. Green: CENP-A phospho Ser18 antibody (pAb) Blue: DAPI 100 μL Log in to see 1 to 2 Days
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of CENPA staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. w Western blot analysis of CENPA expression in HEK293T (A), Raw264.7 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 9 Days
Human Goat Un-conjugated IHC (p) Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6 to 8 Days

CENPA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Mouse (Murine)

Rat (Rattus)

Top referenced anti-CENPA Antibodies

  1. Human Monoclonal CENPA Primary Antibody for ELISA - ABIN394040 : Carroll, Milks, Straight: Dual recognition of CENP-A nucleosomes is required for centromere assembly. in The Journal of cell biology 2010 (PubMed)
    Show all 5 references for ABIN394040

  2. Human Monoclonal CENPA Primary Antibody for WB - ABIN1027707 : Rieder, Salmon: The vertebrate cell kinetochore and its roles during mitosis. in Trends in cell biology 1998 (PubMed)
    Show all 4 references for ABIN1027707

  3. Human Polyclonal CENPA Primary Antibody for WB - ABIN657764 : Sekulic, Bassett, Rogers, Black: The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres. in Nature 2010 (PubMed)
    Show all 2 references for ABIN657764

  4. Human Polyclonal CENPA Primary Antibody for IHC, ELISA - ABIN1534330 : Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005 (PubMed)

  5. Human Polyclonal CENPA Primary Antibody for IHC, WB - ABIN2782448 : Black, Foltz, Chakravarthy, Luger, Woods, Cleveland: Structural determinants for generating centromeric chromatin. in Nature 2004 (PubMed)

  6. Human Polyclonal CENPA Primary Antibody for DB, ICC - ABIN2668362 : Logsdon, Barrey, Bassett, DeNizio, Guo, Panchenko, Dawicki-McKenna, Heun, Black: Both tails and the centromere targeting domain of CENP-A are required for centromere establishment. in The Journal of cell biology 2015 (PubMed)

  7. Cow (Bovine) Polyclonal CENPA Primary Antibody for WB - ABIN2782449 : Orthaus, Biskup, Hoffmann, Hoischen, Ohndorf, Benndorf, Diekmann: Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells. in Chembiochem : a European journal of chemical biology 2007 (PubMed)

More Antibodies against CENPA Interaction Partners

Fruit Fly (Drosophila melanogaster) Centromere Protein A (CENPA) interaction partners

  1. centromere assembly factors CAL1 (show CALCA Antibodies) and CENP-C are required for meiotic chromosome segregation, CENP-A assembly and maintenance on sperm, as well as fertility

  2. identify two co-evolving regions, CENP-A L1 and the CAL1 (show CALCA Antibodies) N terminus, as critical for lineage-specific CENP-A incorporation

  3. A novel role has been described for the histone acetyltransferase (show HAT Antibodies) Hat1 (show HAT1 Antibodies) in the CENP-A/CID assembly pathway in Drosophila melanogaster.

  4. CENP-A assembly by its loading factor, CAL1, requires RNAPII-mediated transcription of the underlying DNA

  5. The amount of Cid that is loaded during each cell cycle appears to be determined primarily by the preexisting centromeric Cid, with little flexibility for compensation of accidental losses.

  6. CID nucleosomes are octameric in vivo and that CID dimerization is essential for correct centromere assembly.

  7. The F box protein (show FBXO30 Antibodies) partner of paired (Ppa (show FBXL14 Antibodies)) mediates CenH3(CID) stability in Drosophila. Ppa (show FBXL14 Antibodies) depletion results in increased CenH3(CID) levels. Ppa (show FBXL14 Antibodies) physically interacts with CenH3(CID) through the CATD (show CTSD Antibodies)(CID) that mediates Ppa (show FBXL14 Antibodies)-dependent CenH3(CID) stability.

  8. Drosophila CENP-C is essential for centromere identity.

  9. Cid allows for contacts betwen DNA and histones and specific targeting

  10. Results suggest that CID mislocalization promotes formation of ectopic centromeres and multicentric chromosomes, which causes chromosome missegregation, aneuploidy, and growth defects.

Human Centromere Protein A (CENPA) interaction partners

  1. CENP-C (show CENPC1 Antibodies) and CENP-I (show CENPI Antibodies) are key factors connecting kinetochore to CENP-A assembly.

  2. The authors found that the nucleosome shape change directed by CENP-A is dominated by lateral passing of two DNA gyres (gyre sliding).

  3. the CRL4 complex containing RBBP7 (show RBBP7 Antibodies) (CRL4(RBBP7 (show RBBP7 Antibodies))) might regulate mitosis by promoting ubiquitin-dependent loading of newly synthesized CENP-A during the G1 phase of the cell cycle.

  4. The DNA ends of the CENP-A nucleosome are more flexible than those of the H3 nucleosome.

  5. We used a synthetic system to dissect how CenH3(CENP-A) contributes to the accumulation of CENP-C (show CENPC1 Antibodies) and CENP-T (show CENPT Antibodies), two key components that are necessary for the formation of functional kinetochores

  6. The CENP-A/histone H3.3 (show H3F3A Antibodies) nucleosome forms an unexpectedly stable structure and allows the binding of the essential centromeric protein, CENP-C (show CENPC1 Antibodies), which is ectopically mislocalized in the chromosomes of CENP-A overexpressing tumor cells.

  7. CENP-B (show CENPB Antibodies) directly binds both CENP-A's amino-terminal tail and CENP-C (show CENPC1 Antibodies), a key nucleator of kinetochore assembly

  8. CENP-C (show CENPC1 Antibodies) depletion leads to rapid removal of CENP-A from centromeres, indicating their collaboration in maintaining centromere identity.

  9. The study describes a novel function for human centromeric long non-coding RNAs in the recruitment of HJURP (show HJURP Antibodies) and CENP-A, implicating RNA-based chaperone targeting in histone variant assembly.

  10. results indicate that the regions of CENP-A required for early events in centromere establishment differ from those that are required for maintaining centromere identity.

Mouse (Murine) Centromere Protein A (CENPA) interaction partners

  1. CPCs maintain relatively high levels of CENP-A early in life, which is necessary for sustaining proliferation, inhibiting senescence, and promoting survival following differentiation of CPCs.

  2. Results report that the level of CENP-A, a protein required for cell division, declines precipitously with age in an islet-specific manner.

  3. Cenpa, Cenpb (show CENPB Antibodies), and Bub3 (show BUB3 Antibodies), but not Cenpc (show CENPC1 Antibodies), interacted with PARP-1 (show PARP1 Antibodies)

  4. The centromere-targeting domain of CENP-A is both necessary and sufficient for recruitment to double-strand breaks. CENP-A accumulation at DNA breaks is enhanced by active non-homologous end-joining but does not require DNA-PKcs (show PRKDC Antibodies) or Ligase IV.

Xenopus laevis Centromere Protein A (CENPA) interaction partners

  1. CENP-A assembly into chromatin requires unidentified deoxycytidine deaminase (show APOBEC3G Antibodies) and UNG2 (show CCNO Antibodies), a uracil DNA glycosylase (show UNG Antibodies).

  2. CENP-A deposition at the centromeres is dependent on HJURP (show HJURP Antibodies).

CENPA Antigen Profile

Protein Summary

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with CENPA

  • centromere identifier (cid) antibody
  • centromere protein-A (CENP-A) antibody
  • centromere protein A (cenpa) antibody
  • centromeric histone-3 like protein (cenp-A) antibody
  • centromere-specific histone H3 CENP-A (cnp1) antibody
  • cenp-A (HAN_3g422) antibody
  • centromere protein A (Cenp-a) antibody
  • centromere protein A (CENPA) antibody
  • centromere protein A (CMU_016480) antibody
  • centromere protein A (Cenpa) antibody
  • centromere protein A-like (LOC100353660) antibody
  • histone H3-like centromeric protein A (cenpa) antibody
  • BcDNA:RE21270 antibody
  • cenH3 antibody
  • CenH3/CID antibody
  • CenH3[Cid] antibody
  • Cenp-a antibody
  • CENP-A/Cid antibody
  • CENP-C antibody
  • cenpA antibody
  • CenpA/CID antibody
  • cenpx antibody
  • CG13329 antibody
  • Cid antibody
  • CID/CENP-A antibody
  • Cid[Mel] antibody
  • Dmel\\CG13329 antibody
  • RGD1563607 antibody
  • sim2 antibody

Protein level used designations for CENPA

CG13329-PA , centromere identifier protein , centromere protein A , cid-PA , centromere protein-A , centromere protein, Xenopus , histone H3-like centromeric protein A , centromeric histone-3 like protein , cenp-A , centromere autoantigen A , centromere protein A, 17kDa , centromere-specific histone , centrosomin A , CENP-A , ggCENP-A

36495 Drosophila melanogaster
407119 Bos taurus
549339 Xenopus (Silurana) tropicalis
857118 Guillardia theta
2539658 Schizosaccharomyces pombe 972h-
5739547 Hemiselmis andersenii
100233153 Nasonia vitripennis
459086 Pan troglodytes
697312 Macaca mulatta
6995376 Cryptosporidium muris RN66
613898 Bos taurus
1058 Homo sapiens
12615 Mus musculus
298850 Rattus norvegicus
475692 Canis lupus familiaris
100724949 Cavia porcellus
100113359 Gallus gallus
101110750 Ovis aries
735079 Xenopus laevis
100689459 Cricetulus griseus
100353660 Oryctolagus cuniculus
100302659 Danio rerio
Selected quality suppliers for anti-CENPA (CENPA) Antibodies
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