anti-Cereblon (CRBN) Antibodies

CRBN encodes a protein related to the Lon protease protein family. Additionally we are shipping Cereblon Kits (20) and Cereblon Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CRBN 297498 Q56AP7
CRBN 51185 Q96SW2
CRBN 58799 Q8C7D2
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Top anti-Cereblon Antibodies at antibodies-online.com

Showing 10 out of 35 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CRBN Antibody Titration: 0.2-1 ug/mlPositive Control: COLO205 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), SimWes, WB Simple Western: CRBN Antibody [NBP1-91810] - Simple Western lane view shows a specific band for CRBN in 0.2 mg/ml of RT4 (left), U-251MG (right) lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. Immunocytochemistry/Immunofluorescence: CRBN Antibody [NBP1-91810] - Immunofluorescent staining of human cell line U-251 MG shows positivity in nucleoli. Recommended conditions: Fixation/Permeabilization: PFA/Triton X-100 Working concentration: 1-4 ug/ml 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Mouse Un-conjugated WB Western Blot analysis of CRBN expression in transfected 293T cell line by CRBN MaxPab polyclonal antibody.Lane 1: CRBN transfected lysate(48.62 KDa).Lane 2: Non-transfected lysate. 50 μg Log in to see 11 to 12 Days
$430.00
Details
Cow Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IF, IHC, WB 100 μL Log in to see 16 Days
$460.63
Details
Human Rabbit Un-conjugated WB Western Blot: CRBN Antibody [NBP1-56305] - RPMI-8226 Whole Cell lysates, Antibody Dilution: 0.5 ug/ml. Western Blot: CRBN Antibody [NBP1-56305] - Reccomended Titration: 0.2 - 1 ug/ml Positive Control: COLO205 cell lysate 50 μL Log in to see 7 to 9 Days
$447.56
Details
Cow Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

CRBN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Cereblon Antibodies

  1. Human Polyclonal CRBN Primary Antibody for WB - ABIN526543 : Charoenfuprasert, Yang, Lee, Chao, Chu, Lai, Hsu, Chang, Chen, Chen, Chang, Leu, Shih: Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer. in Oncogene 2011 (PubMed)
    Show all 3 references for 526543

  2. Human Polyclonal CRBN Primary Antibody for ICC, IF - ABIN4300387 : Gandhi, Mendy, Waldman, Chen, Rychak, Miller, Gaidarova, Ren, Wang, Breider, Carmel, Mahmoudi, Jackson, Abbasian, Cathers, Schafer, Daniel, Lopez-Girona, Thakurta, Chopra: Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity. in British journal of haematology 2014 (PubMed)

More Antibodies against Cereblon Interaction Partners

Human Cereblon (CRBN) interaction partners

  1. CRBN negatively regulates TLR4 (show TLR4 Antibodies) signaling via attenuation of TRAF6 (show TRAF6 Antibodies) and TAB2 (show TAB2 Antibodies) ubiquitination.

  2. Compared with newly diagnosed multiple myeloma, an increased prevalence of mutations in the Ras pathway genes KRAS, NRAS (show NRAS Antibodies), and/or BRAF (show BRAF Antibodies) (72%), as well as TP53 (show TP53 Antibodies) (26%), CRBN (12%), and CRBN pathway genes (10%) was observed.

  3. results suggest that CRBN binds to Ikaros (show IKZF1 Antibodies) via its N-terminal region and regulates transcriptional activities of Ikaros (show IKZF1 Antibodies) and its downstream target, enkephalin

  4. dual assay demonstrated superior Cereblon IHC measurement in MM samples compared with the single IHC assay using a published commercial rabbit polyclonal Cereblon antibody and could be used to explore the potential utility of Cereblon as a biomarker in the clinic

  5. IRF4 (show IRF4 Antibodies) and CRBN polymorphisms affect risk and response to treatment in multiple myeloma

  6. overview of the current understanding of mechanism of action of Immunomodulatory drugs via CRBN and prospects for the development of new drugs that degrade protein of interest.

  7. 45.2 of multiple myeloma patients were CRBN(+). Among patients treated with thalidomide-based regimens, CRBN(+) patients showed a better treatment response than did CRBN-negative patients. There was no significant difference in survival outcomes between thalidomide- and bortezomib-based regimens in CRBN(+) patients.

  8. These results support the notion that the cereblon binding partner AGO2 (show EIF2C2 Antibodies) plays an important role in regulating MM cell growth and survival and AGO2 (show EIF2C2 Antibodies) could be considered as a novel drug target for overcoming IMiD resistance in MM cells.

  9. The anti-PEL effects of IMiDs involved cereblon-dependent suppression of IRF4 (show IRF4 Antibodies) and rapid degradation of IKZF1 (show IKZF1 Antibodies), but not IKZF3 (show IKZF3 Antibodies). Small hairpin RNA-mediated knockdown of MYC (show MYC Antibodies) enhanced the cytotoxicity of IMiDs

  10. GS is acetylated at lysines 11 and 14, yielding a degron that is necessary and sufficient for binding and ubiquitylation by CRL4(CRBN) and degradation by the proteasome.

Mouse (Murine) Cereblon (CRBN) interaction partners

  1. CRBN negatively regulates TLR4 (show TLR4 Antibodies) signaling via attenuation of TRAF6 (show TRAF6 Antibodies) and TAB2 (show TAB2 Antibodies) ubiquitination.

  2. CRBN is involved in the activation of PERK (show EIF2AK3 Antibodies) and the Ire1 (show ERN1 Antibodies) pathway of the unfolded protein response.CRBN plays a role in cellular stress signaling, including the unfolded protein response, by controlling the activity of AMPK (show PRKAA1 Antibodies).

  3. results of this study suggest a plausible mechanism for CRBN involvement in higher brain function in humans, and they may help explain how a specific mutation in CRBN can affect the cognitive ability of patients

  4. Found significantly smaller infarct sizes and less fibrosis in the hearts of CRBN KO mice than in those of WT mice. Apoptosis was also significantly reduced in the KO mice compared with that in WT mice.

  5. findings suggest that crbn-/- mice exhibit selective HPC-dependent deficits in associative learning.

  6. CRBN directly interacts with the alpha1 subunit of AMP-activated protein kinase (AMPK (show PRKAA2 Antibodies) alpha1) and inhibits the activation of AMPK (show PRKAA1 Antibodies) activation.

  7. These results imply that Nrf2 (show NFE2L2 Antibodies) stimulates CRBN gene transcription under hypoxia-reoxygenation conditions in neuronal cells.

Cereblon (CRBN) Antigen Profile

Protein Summary

This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with anti-Cereblon (CRBN) Antibodies

  • cereblon (crbn) antibody
  • cereblon (CRBN) antibody
  • ATP-dependent protease La (LON) domain protein (AT2G25740) antibody
  • cereblon (Crbn) antibody
  • 2610203G15Rik antibody
  • 2900045O07Rik antibody
  • AF229032 antibody
  • AW108261 antibody
  • F3N11.21 antibody
  • MRT2 antibody
  • MRT2A antibody
  • piL antibody
  • zgc:92404 antibody

Protein level used designations for anti-Cereblon (CRBN) Antibodies

protein cereblon , zcrbn , cereblon , protein cereblon-like , protein x 0001 , novel lethal , protein PiL , Protein cereblon

GENE ID SPECIES
445491 Danio rerio
100052958 Equus caballus
704436 Macaca mulatta
460130 Pan troglodytes
493554 Xenopus (Silurana) tropicalis
100022278 Monodelphis domestica
100479474 Ailuropoda melanoleuca
817117 Arabidopsis thaliana
100584605 Nomascus leucogenys
297498 Rattus norvegicus
51185 Homo sapiens
58799 Mus musculus
511585 Bos taurus
416104 Gallus gallus
476551 Canis lupus familiaris
100174633 Pongo abelii
Selected quality suppliers for anti-Cereblon (CRBN) Antibodies
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