Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

CRBN antibody (AA 1-280)

CRBN Reactivity: Human WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7165198
  • Key Features
    • Rabbit anti-CRBN Antibody reliably detects CRBN in human species.
    • Polyclonal, unconjugated antibody for ELISA, WB, IHC.
    • Highly specific CRBN detection. See validation images.
    Target See all CRBN Antibodies
    CRBN (Cereblon (CRBN))
    Binding Specificity
    • 15
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-280
    Reactivity
    • 20
    • 19
    • 10
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 23
    • 2
    Rabbit
    Clonality
    • 25
    Polyclonal
    Conjugate
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CRBN antibody is un-conjugated
    Application
    • 13
    • 13
    • 10
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Cross-Reactivity
    Human, Mouse
    Purification
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Protein cereblon protein (1-280AA)
    Isotype
    IgG
    Product Specific Information

    What can the CRBN antibody ABIN7165198 be used for? This polyclonal, unconjugated rabbit anti-CRBN antibody is suitable for the detection of cereblon (CRBN) in ELISA, Western blotting and immunohistochemistry. The CRBN antibody has been validated for the human species. Based on the sequence, cross-reactivity with mouse can be assumed. Recombinant human cereblon protein was used as immunogen for production.

    What validation data is available for this CRBN antibody? The CRBN antibody currently has three product images demonstrating its performance in IHC and Western blot. Use our high-quality CRBN Antibody to reliably detect Cereblon.

    What is the function of CRBN? CRBN is a substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 or ILF2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. CRBN maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. (UniProt)

  • Application Notes
    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    CRBN (Cereblon (CRBN))
    Alternative Name
    CRBN (CRBN Products)
    Synonyms
    zgc:92404 antibody, mrt2a antibody, F3N11.21 antibody, MRT2 antibody, MRT2A antibody, 2610203G15Rik antibody, 2900045O07Rik antibody, AF229032 antibody, AW108261 antibody, piL antibody, cereblon antibody, ATP-dependent protease La (LON) domain protein antibody, crbn antibody, CRBN antibody, AT2G25740 antibody, Crbn antibody
    Background

    Background: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.

    Aliases: 2610203G15Rik antibody, 2900045O07Rik antibody, AF229032 antibody, AW108261 antibody, Cereblon antibody, Crbn antibody, CRBN_HUMAN antibody, DKFZp781K0715 antibody, MGC27358 antibody, MRT2A antibody, OTTHUMP00000209555 antibody, piL antibody, Protein cereblon antibody, Protein x 0001 antibody

    UniProt
    Q96SW2
You are here: