CRBN antibody (AA 210-288)

Catalog No. ABIN1387716

The Rabbit Polyclonal anti-CRBN antibody (ABIN1387716) specifically detects CRBN in IF (cc), IF (p), IHC (p) and IHC (fro). The antibody is reactive with Human samples.

Quick Overview for CRBN antibody (AA 210-288) (ABIN1387716)

Target: CRBN (Cereblon (CRBN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRBN antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CRBN Antibody

Binding Specificity: AA 210-288

Purpose: CRBN Polyclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Pig,Horse,Rabbit,Zebrafish

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CRBN

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CRBN

Target: CRBN (Cereblon (CRBN))

Alternative Name: CRBN

Background:

Synonyms: Cereblon, DKFZp781K0715, MGC27358, MRT2A, OTTHUMP00000209555, piL, Protein cereblon, Protein x 0001, 2610203G15Rik, 2900045O07Rik, AF229032, AW108261, CRBN_HUMAN.

Background: CRBN is a 442 amino acid protein which is highly concentrated in human brain tissue. CRBN functions are thought to be related to energy metabolism, learning and memory. Localized to the cytoplasm, CRBN acts as a protease in mitochondria and is thought to regulate the assembly of KCNT1, as well as the surface expression of KCNT1 in brain regions known to affect memory and learning, such as the hippocampus. The gene encoding CRBN belongs to a family of ATP-dependent lon proteases that play a role in membrane trafficking and proteolysis. Defects in the CRBN gene are associated with mild mental retardation.