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The protein encoded by CP is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Additionally we are shipping Ceruloplasmin (Ferroxidase) Kits (101) and Ceruloplasmin (Ferroxidase) Proteins (15) and many more products for this protein.
Showing 10 out of 118 products:
Human Monoclonal CP Primary Antibody for IF, WB - ABIN968559
Attieh, Mukhopadhyay, Seshadri, Tripoulas, Fox: Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism. in The Journal of biological chemistry 1999
Show all 5 references for ABIN968559
Human Polyclonal CP Primary Antibody for EIA, WB - ABIN452864
Altamura, Squitti, Pasqualetti, Gaudino, Palazzo, Tibuzzi, Lupoi, Cortesi, Rossini, Vernieri: Ceruloplasmin/Transferrin system is related to clinical status in acute stroke. in Stroke; a journal of cerebral circulation 2009
Show all 2 references for ABIN452864
In D-galactosamine-sensitized mice CP+Cu(II) increased the LPS (show TLR4 Antibodies)-induced lethality from 54 to 100%, while administration of antibodies against MIF (show MIF Antibodies) prevented the lethal effect. The enhancement by CP+Cu(II) of the pro-inflammatory signal of MIF (show MIF Antibodies) is discussed
mice with mutation of Cp and Heph (show HEPH Antibodies), iron accumulates in glia, while neurons have low iron levels. Both neurons and glia degenerate and mice become ataxic unless given an iron chelator.
Data (including data from studies in knockout mice) suggest that ceruloplasmin and hephaestin (show HEPH Antibodies) play distinct roles in regulation of gene expression in various regions of the brain and are involved in iron homeostasis.
Evidence supports a regulatory role of both proteins (Ceruloplasmin (CP) and beta-amyloid protein precursor (APP (show APP Antibodies))) in defence against iron-induced oxidative damage after TBI, which presents as a tractable therapeutic target.
Genetic interactions between Cp, Mon1a (show MON1A Antibodies), and the Slc40a1 (show SLC40A1 Antibodies) locus are involved in iron metabolism.
ceruloplasmin should provide a protective shield against inadvertent oxidant production by myeloperoxidase (show MPO Antibodies) during inflammation
The mouse ceruloplasmin gene has been mapped to chromosome 3.
Data found an increase in ceruloplasmin levels in the plasma of Npc1 (show NPC1 Antibodies) -/- mice compared to Npc1 (show NPC1 Antibodies) +/+ mice, and this increase was statistically significant (*p < 0.05).
Cp and Heph (show HEPH Antibodies) are necessary for iron export from the retina but are not essential for iron import into the retina.
pathological cerebrospinal fluid's environment of Parkinson's disease patients promoted the same modifications in the exogenously added ceruloplasmin
PON-1 (show PON1 Antibodies) and ferroxidase activities in older patients with mild cognitive impairment, late onset Alzheimer's disease or vascular dementia
we have through bioinformatic screening identified ceruloplasmin as a novel adipokine with increased expression in adipose tissue of obese subjects as well as in cells from obesity-associated cancers.
brain microvascular endothelial cell -secreted cytokine activity increases the gene expression of neighboring C6 glioma CP, which reciprocally acts on basolateral BMVEC ferroportin (show SLC40A1 Antibodies) to enhance brain iron import
High ceruloplasmin levels are associated with preeclampsia.
A reduced serum FeOx activity, which can potentially lead to a rise in oxidative stress-induced (show SQSTM1 Antibodies) biomolecular damage, seems to be a shared condition in inflammatory disorders of the central nervous system including MS.
This review describes the main role of ceruloplasmin in iron turnover is oxidizing Fe2+ into Fe3+, a process which is essential for iron binding to transferrin (show Tf Antibodies) (the main iron-transporting protein), as well as to ferritin (show FTL Antibodies) (the main iron-storage protein)
ceruloplasmin and hepcidin (show HAMP Antibodies) differentially regulate iron efflux from brain microvascular endothelial cells
The core-fucosylation ratio of ceruloplasmin increases significantly in alcohol-related hepatocellular carcinoma.
In CKD patients, increased serum ceruloplasmin, a regulator of nitric oxide activity, is associated with increased risk of long-term adverse cardiovascular events, even after multivariable model adjustment for traditional clinical/biologic risk factors.
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
, hypothetical protein
, ceruloplasmin (ferroxidase)