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CXCR4 encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. Additionally we are shipping CXCR4 Kits (26) and CXCR4 Proteins (14) and many more products for this protein.
Showing 10 out of 466 products:
Human Polyclonal CXCR4 Primary Antibody for EIA, WB - ABIN499698
Berson, Long, Doranz, Rucker, Jirik, Doms: A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains. in Journal of virology 1996
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Human Polyclonal CXCR4 Primary Antibody for EIA, IF - ABIN499700
Dimitrov: How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity. in Cell 1998
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Human Monoclonal CXCR4 Primary Antibody for FACS - ABIN2853593
Nimura, Zhang, Okuma, Tanaka, Sunakawa, Yamamoto, Tanaka: Cross-linking cell surface chemokine receptors leads to isolation, activation, and differentiation of monocytes into potent dendritic cells. in Experimental biology and medicine (Maywood, N.J.) 2006
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Human Polyclonal CXCR4 Primary Antibody for EIA, IF - ABIN499696
Feng, Broder, Kennedy, Berger: HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. in Science (New York, N.Y.) 1996
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Human Polyclonal CXCR4 Primary Antibody for EIA, IHC (fro) - ABIN492892
Tran, Miller: Chemokine receptors: signposts to brain development and disease. in Nature reviews. Neuroscience 2003
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Chimpanzee Monoclonal CXCR4 Primary Antibody for FACS, IHC (fro) - ABIN264477
Endres, Clapham, Marsh, Ahuja, Turner, McKnight, Thomas, Stoebenau-Haggarty, Choe, Vance, Wells, Power, Sutterwala, Doms, Landau, Hoxie: CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. in Cell 1997
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Human Polyclonal CXCR4 Primary Antibody for IP, IHC - ABIN223559
Miwa, Mizokami, Keller, Taichman, Zhang, Namiki: The bisphosphonate YM529 inhibits osteolytic and osteoblastic changes and CXCR-4-induced invasion in prostate cancer. in Cancer research 2005
Human Polyclonal CXCR4 Primary Antibody for IF, ELISA - ABIN1535575
Federsppiel, Melhado, Duncan, Delaney, Schappert, Clark-Lewis, Jirik: Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen. in Genomics 1993
Human Polyclonal CXCR4 Primary Antibody for FACS, IHC - ABIN2779387
Yoshitake, Fukui, Yamagishi, Sekikawa, Fujii, Tomita, Ichikawa, Imura, Hiraishi, Fujimori: Expression of SDF-1 alpha and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer. in British journal of cancer 2008
Human Polyclonal CXCR4 Primary Antibody for WB - ABIN223599
Tillmanns, Rota, Hosoda, Misao, Esposito, Gonzalez, Vitale, Parolin, Yasuzawa-Amano, Muraski, De Angelis, Lecapitaine, Siggins, Loredo, Bearzi, Bolli, Urbanek, Leri, Kajstura, Anversa: Formation of large coronary arteries by cardiac progenitor cells. in Proceedings of the National Academy of Sciences of the United States of America 2008
bilateral lineup in the trunk before PGC (show PGC Antibodies) migration colonizing gonadal areas is defective in PGCS expressing a missense mutation in chemokine receptor (show CCR1 Antibodies) gene cxcr4b
crosstalk between astrocytic CXCL12 (show CXCL12 Antibodies) and microglial CXCR4 in the pathogenesis of neuropathic pain.
Results from using a plasmid transient expression of shRNA antiCXR4 shown that CXCR4 plays a critical role in the initial stages of development of murine melanoma B16F10 melanoma.
DPP-4 (show DPP4 Antibodies) inhibition may have direct protective effects on the post-myocardial infarction heart by inducing an antiapoptotic effect and inhibiting a decrease in vessel number through the SDF-1a/CXCR4-mediated STAT3 (show STAT3 Antibodies) signaling pathway.
confirm a pivotal role of the SDF-1 (show CXCL12 Antibodies)/CXCR4/CXCR7 (show CXCR7 Antibodies) axis for chronic allograft vasculopathy development
CXCR4 has an important role in endothelial progenitor cells migration at the ischemic site.
CXCR4/CXCL12 (show CXCL12 Antibodies) signaling may control movement of epithelial progenitors from the dental stem cell niche.
our present study provided evidence that SDF-1 (show CXCL12 Antibodies) mediated CSCs migration through CXCR4 and CXCR7 (show CXCR7 Antibodies) via MEK (show MDK Antibodies)/ERK (show EPHB2 Antibodies) and PI3K/Akt (show AKT1 Antibodies) pathway
Endothelial CXCR4 is negatively regulated by miR (show MLXIP Antibodies)-139-5p, whose transcription is in turn induced by laminar flow and APLN (show APLN Antibodies)/APLNR (show APLNR Antibodies) signalling.
CXCR4 signaling has a role in radiation-induced lung damage that promotes breast cancer lung-metastasis
Splenic TFF2 (show TFF2 Antibodies), a secreted anti-inflammatory peptide, is released by vagally modulated memory T cells to suppress the expansion of myeloid-derived suppressor cells through CXCR4.
Using Bioluminescence Resonance Energy Transfer and luciferase-complementation based methods the study show that US22 expression exhibits negative effects on CXCR4 signaling and constitutive surface expression in HEK293T cells.
miR (show MLXIP Antibodies)-204-5p may function as an inhibitory RNA molecule in oral squamous cell carcinoma by targeting CXCR4.
From our data we conclude that targeting of CXCR4 and FAK (show PTK2 Antibodies) may overcome ABCB1 (show ABCB1 Antibodies) and ABCC1 (show ABCC1 Antibodies)-dependent doxorubicin resistance in non-small cell lung carcinoma cells
In GNC analysis, SNAI2 (show SNAI2 Antibodies) mRNA gene but not ITGA5 (show ITGA5 Antibodies), RGS2 (show RGS2 Antibodies) and PLEK2 (show PLEK2 Antibodies) was dependent on the signaling pathway of CXCR4.
The CXCR4 genotype C>T of rs2228014 appeared to correlate with acute myeloid leukemia (show BCL11A Antibodies) risk, but played no role in leukemia cells invading the bloodstream.
High CXCR4 expression in primary breast tumors (PTs (show PTS Antibodies)) was found to be associated with luminal A type tumor, suggesting more favorable outcome. In contrast, CCR7 (show CCR7 Antibodies) and FOXP3 (show FOXP3 Antibodies) expressions in PTs (show PTS Antibodies) represented luminal B tumors, pointing to more aggressive tumor behavior. Maspin (show SERPINB5 Antibodies) expression did not differ between luminal types.
Exhibiting similar power of significance compared to CXCR3 (show CXCR3 Antibodies), CXCR4 expression also served as a predictor for clinical outcome in chronic lymphocytic leukemia patients.
Exposure of CD133+ cells isolated from cord blood to PMPs with 10 mug/ml concentration increased the expression of CXCR4 surface marker significantly.
These results suggested that RTN3 (show RTN3 Antibodies) modulates primordial germ cell migration through interaction with, and regulation of, CXCR4.
we observed time points where surface CXCR4 appeared fully occupied but MEDI3185 was not detectable in serum. These paradoxical results represented a type of assay interference, and by comparing pharmacokinetic, ADA (show ADA Antibodies) and total CXCR4 results, the most likely reason for the free CXCR4 results was the emergence of neutralizing anti-drug antibodies (ADA (show ADA Antibodies)).
CXCR4 controls leukocyte mobilization after trauma.
The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1 (show CXCL12 Antibodies)/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.
reports transmural and perivascular expression patterns of chemokines CCL2 (show CCL2 Antibodies) and CXCL2 (show CXCL2 Antibodies) and of chemokine (show CCL1 Antibodies) receptors CCR2 (show CCR2 Antibodies), CCR5 (show CCR5 Antibodies), and CXCR4 following coronary angioplasty
There is a potential link between follicular SDF1 (show CXCL12 Antibodies)/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.
The combination of low expression of CXCR4 and high expression of IL-10 (show IL10 Antibodies) might be closely concerned with some bias for the production of PI calves.
The increased CXCR4 and CXCR7 (show CXCR7 Antibodies) expression resulted in increased SDF-1 (show CXCL12 Antibodies)-induced RF/6A cell migration and tube formation.
The CXCR7 (show CXCR7 Antibodies)/CXCR4/CXCL12 (show CXCL12 Antibodies) axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.
These findings suggest that FBLN5 (show FBLN5 Antibodies) may interfere with choroidal neovascularization by downregulating VEGF (show VEGFA Antibodies), CXCR4, and TGFB1 (show TGFB1 Antibodies) expression and inhibiting choroidl endothelial cell proliferation.
Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 (show CCR5 Antibodies) and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively
Arteries are formed by vein-derived endothelial tip cells, this process critically depends on chemokine receptor Cxcr4 function.
SDF1a (show CXCL12 Antibodies) directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7 (show CXCR7 Antibodies).
Hoxb8a is induced by and cooperates with Wnt (show WNT2 Antibodies) signaling to up-regulate cxcr4b, and acts through multiple mechanisms to repress cxcr7b expression.
Expression of Cxcr4 and Cxcl12 (show CXCL12 Antibodies) in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12 (show CXCL12 Antibodies)/Cxcr4 pair in brain development and functioning.
show that inactivation of the estrogen receptor ESR1 (show ESR1 Antibodies) results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 (show ESR1 Antibodies) overexpression results in a reciprocal reduction in the domain of cxcr4b expression.
Study suggest that the Cxcl12a-Cxcr4b ligand-receptor pair are involved in the migration of GnRH3 neurons in zebrafish, and are therefore crucial for the development of this system.
A CXCR4-like chemokine receptor (show CCR1 Antibodies) is expressed by the migrating lateral line primordium cells. Both the formation and the innervation of this system depend on the SDF1 (show CXCL12 Antibodies)-CXCR4 system.
Knocking down CXCR4 results in severe defects in primordial germ cell migration.
SDF-1 (show CXCL12 Antibodies)/CXCR4 signaling is important for guiding retinal ganglion cell axons within the retina to the optic stalk to exit the retina.
chemokine (show CCL1 Antibodies) signaling contributes to both the olfactory placode assembly and the olfactory sensory neurons axon pathfinding in zebrafish
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
C-X-C chemokine receptor type 4
, SDF-1 receptor
, Stromal cell-derived factor 1 receptor
, chemokine (C-X-C motif) receptor 4
, chemokine (C-X-C) receptor 4
, chemokine receptor 4
, leukocyte-derived seven transmembrane domain receptor
, leukocyte-expressed seven-transmembrane-domain
, pre-B-cell-derived chemokine receptor
, stromal cell-derived factor 1 receptor
, CXC chemokine receptor
, chemokine receptor (LCR1)
, CD184 antigen
, leukocyte-derived seven-transmembrane-domain receptor
, lipopolysaccharide-associated protein 3
, neuropeptide Y receptor Y3
, seven transmembrane helix receptor
, seven-transmembrane-segment receptor, spleen
, C-X-C chemokine receptor type 4-B
, SDF-1 receptor B
, SDF-1 receptor-B
, Stromal cell-derived factor 1 receptor-B
, stromal cell-derived factor 1 receptor B
, chemokine receptor CXCR4
, CXC chemokine receptor 4