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CXCR4 encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. Additionally we are shipping CXCR4 Kits (30) and CXCR4 Proteins (20) and many more products for this protein.
Showing 10 out of 471 products:
Human Polyclonal CXCR4 Primary Antibody for EIA, WB - ABIN499698
Berson, Long, Doranz, Rucker, Jirik, Doms: A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains. in Journal of virology 1996
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Human Monoclonal CXCR4 Primary Antibody for FACS - ABIN2853593
Nimura, Zhang, Okuma, Tanaka, Sunakawa, Yamamoto, Tanaka: Cross-linking cell surface chemokine receptors leads to isolation, activation, and differentiation of monocytes into potent dendritic cells. in Experimental biology and medicine (Maywood, N.J.) 2006
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Human Polyclonal CXCR4 Primary Antibody for EIA, IF - ABIN499696
Dimitrov: How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity. in Cell 1998
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Chimpanzee Monoclonal CXCR4 Primary Antibody for FACS, IHC (fro) - ABIN264477
Endres, Clapham, Marsh, Ahuja, Turner, McKnight, Thomas, Stoebenau-Haggarty, Choe, Vance, Wells, Power, Sutterwala, Doms, Landau, Hoxie: CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. in Cell 1997
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Human Polyclonal CXCR4 Primary Antibody for EIA, IHC (fro) - ABIN492892
Tran, Miller: Chemokine receptors: signposts to brain development and disease. in Nature reviews. Neuroscience 2003
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Chicken Polyclonal CXCR4 Primary Antibody for IHC (p) - ABIN270615
Bhutto, McLeod, Merges, Hasegawa, Lutty: Localisation of SDF-1 and its receptor CXCR4 in retina and choroid of aged human eyes and in eyes with age related macular degeneration. in The British journal of ophthalmology 2006
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Human Polyclonal CXCR4 Primary Antibody for IP, IHC - ABIN223559
Miwa, Mizokami, Keller, Taichman, Zhang, Namiki: The bisphosphonate YM529 inhibits osteolytic and osteoblastic changes and CXCR-4-induced invasion in prostate cancer. in Cancer research 2005
Human Polyclonal CXCR4 Primary Antibody for IF, ELISA - ABIN1535575
Federsppiel, Melhado, Duncan, Delaney, Schappert, Clark-Lewis, Jirik: Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen. in Genomics 1993
Human Polyclonal CXCR4 Primary Antibody for FACS, IHC - ABIN2779387
Yoshitake, Fukui, Yamagishi, Sekikawa, Fujii, Tomita, Ichikawa, Imura, Hiraishi, Fujimori: Expression of SDF-1 alpha and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer. in British journal of cancer 2008
Human Polyclonal CXCR4 Primary Antibody for WB - ABIN223599
Tillmanns, Rota, Hosoda, Misao, Esposito, Gonzalez, Vitale, Parolin, Yasuzawa-Amano, Muraski, De Angelis, Lecapitaine, Siggins, Loredo, Bearzi, Bolli, Urbanek, Leri, Kajstura, Anversa: Formation of large coronary arteries by cardiac progenitor cells. in Proceedings of the National Academy of Sciences of the United States of America 2008
bilateral lineup in the trunk before PGC (show PGC Antibodies) migration colonizing gonadal areas is defective in PGCS expressing a missense mutation in chemokine receptor (show CCR1 Antibodies) gene cxcr4b
CXCR4 expression was significantly associated with higher rate of metastasis and poor prognosis in patients with bone and soft tissue sarcoma. (Meta-analysis)
the present study indicates that the CXCL12 (show CXCL12 Antibodies)/CXCR4 signaling pathway is important during the development of cochleae in neonatal mice.
crosstalk between astrocytic CXCL12 (show CXCL12 Antibodies) and microglial CXCR4 in the pathogenesis of neuropathic pain.
Results from using a plasmid transient expression of shRNA antiCXR4 shown that CXCR4 plays a critical role in the initial stages of development of murine melanoma B16F10 melanoma.
DPP-4 (show DPP4 Antibodies) inhibition may have direct protective effects on the post-myocardial infarction heart by inducing an antiapoptotic effect and inhibiting a decrease in vessel number through the SDF-1a/CXCR4-mediated STAT3 (show STAT3 Antibodies) signaling pathway.
confirm a pivotal role of the SDF-1 (show CXCL12 Antibodies)/CXCR4/CXCR7 (show CXCR7 Antibodies) axis for chronic allograft vasculopathy development
CXCR4 has an important role in endothelial progenitor cells migration at the ischemic site.
CXCR4/CXCL12 (show CXCL12 Antibodies) signaling may control movement of epithelial progenitors from the dental stem cell niche.
our present study provided evidence that SDF-1 (show CXCL12 Antibodies) mediated CSCs migration through CXCR4 and CXCR7 (show CXCR7 Antibodies) via MEK (show MDK Antibodies)/ERK (show EPHB2 Antibodies) and PI3K/Akt (show AKT1 Antibodies) pathway
Endothelial CXCR4 is negatively regulated by miR (show MLXIP Antibodies)-139-5p, whose transcription is in turn induced by laminar flow and APLN (show APLN Antibodies)/APLNR (show APLNR Antibodies) signalling.
mass spectrum followed by immunoprecipitation identified non-muscle myosin heavy chain-IIA (NMMHC-IIA (show MYH9 Antibodies)) as the CXCR4-interacting protein. Furthermore, pharmaceutical inhibition of NMMHC-IIA (show MYH9 Antibodies) by blebbistatin dampened the nuclear translocation of CXCR4 as well as the metastatic capacity of RCC (show XRCC1 Antibodies) cells
CXCL12 (show CXCL12 Antibodies) may be an effective diagnostic marker for papillary thyroid carcinoma, and CXCL12 (show CXCL12 Antibodies)/CXCR4/CXCR7 (show CXCR7 Antibodies) axis may contribute to thyroid cancer development by regulating cancer cell migration and invasion via AKT (show AKT1 Antibodies) and ERK (show EPHB2 Antibodies) signaling and MMP-2 (show MMP2 Antibodies) activation.
Higher percentage of CXCR4-expressing lung metastatic cells compared to the corresponding primary tumors point to important functions of the CXCL12 (show CXCL12 Antibodies)/CXCR4 axis in late steps of metastasis
we found that CXCR4-CXCL12 (show CXCL12 Antibodies)/AKT (show AKT1 Antibodies) axis regulates RhoA (show RHOA Antibodies), Rac-1, and Cdc42 (show CDC42 Antibodies) to modulate cell invasion and tumor metastasis. Together, these results demonstrate a role for CXCR4 in ESCC metastasis and progression and suggest potential targets for therapeutic intervention.
MiR (show MLXIP Antibodies)-381 was predicted as a regulatory miRNA of CXCR4 in breast cancer.
CXCR4 gene polymorphism associated with increase risk of cancer especially among Asian ethnicity.
The endometrial tissue showed significantly lower levels of miR (show MLXIP Antibodies)-200b, miR (show MLXIP Antibodies)-15a-5p, miR (show MLXIP Antibodies)-19b-1-5p, miR (show MLXIP Antibodies)-146a-5p, and miR (show MLXIP Antibodies)-200c, and higher levels of miR-16 (show GDE1 Antibodies)-5p, miR (show MLXIP Antibodies)-106b-5p, and miR (show MLXIP Antibodies)-145-5p. VEGFA (show VEGFA Antibodies) was significantly upregulated, whereas EGFR2, PTEN (show PTEN Antibodies), and CXCR4 were markedly downregulated, in the endometriotic tissues compared to that in the normal endometrial tissues
CXCR4 overexpression promoted mesenchymal stem cell retention within the intervertebral disc and enhanced the stem cell-based intervertebral disc regeneration
Both CXCR4 and MMP9 (show MMP9 Antibodies) were independent predictors for overall survival and metastasis-free survival by Cox (show COX8A Antibodies) multivariate analysis, and high expression for both CXCR4 and MMP9 (show MMP9 Antibodies) were even more significant and better biomarkers for osteosarcoma metastasis and survival. The combination of CXCR4 and MMP9 (show MMP9 Antibodies) high expression is very likely to be a valuable independent predictor of lung metastasis and survival in osteosarcoma patients
The SDF-1 (show CXCL12 Antibodies)/CXCR4 chemokine (show CCL1 Antibodies) axis plays a key role in UM cell proliferation and migration.
CXCR4 controls leukocyte mobilization after trauma.
The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1 (show CXCL12 Antibodies)/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.
reports transmural and perivascular expression patterns of chemokines CCL2 (show CCL2 Antibodies) and CXCL2 (show CXCL2 Antibodies) and of chemokine (show CCL1 Antibodies) receptors CCR2 (show CCR2 Antibodies), CCR5 (show CCR5 Antibodies), and CXCR4 following coronary angioplasty
There is a potential link between follicular SDF1 (show CXCL12 Antibodies)/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.
The combination of low expression of CXCR4 and high expression of IL-10 (show IL10 Antibodies) might be closely concerned with some bias for the production of PI calves.
The increased CXCR4 and CXCR7 (show CXCR7 Antibodies) expression resulted in increased SDF-1 (show CXCL12 Antibodies)-induced RF/6A cell migration and tube formation.
The CXCR7 (show CXCR7 Antibodies)/CXCR4/CXCL12 (show CXCL12 Antibodies) axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.
These findings suggest that FBLN5 (show FBLN5 Antibodies) may interfere with choroidal neovascularization by downregulating VEGF (show VEGFA Antibodies), CXCR4, and TGFB1 (show TGFB1 Antibodies) expression and inhibiting choroidl endothelial cell proliferation.
Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 (show CCR5 Antibodies) and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively
Arteries are formed by vein-derived endothelial tip cells, this process critically depends on chemokine receptor Cxcr4 function.
SDF1a (show CXCL12 Antibodies) directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7 (show CXCR7 Antibodies).
Hoxb8a is induced by and cooperates with Wnt (show WNT2 Antibodies) signaling to up-regulate cxcr4b, and acts through multiple mechanisms to repress cxcr7b expression.
Expression of Cxcr4 and Cxcl12 (show CXCL12 Antibodies) in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12 (show CXCL12 Antibodies)/Cxcr4 pair in brain development and functioning.
show that inactivation of the estrogen receptor ESR1 (show ESR1 Antibodies) results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 (show ESR1 Antibodies) overexpression results in a reciprocal reduction in the domain of cxcr4b expression.
Study suggest that the Cxcl12a-Cxcr4b ligand-receptor pair are involved in the migration of GnRH3 neurons in zebrafish, and are therefore crucial for the development of this system.
A CXCR4-like chemokine receptor (show CCR1 Antibodies) is expressed by the migrating lateral line primordium cells. Both the formation and the innervation of this system depend on the SDF1 (show CXCL12 Antibodies)-CXCR4 system.
Knocking down CXCR4 results in severe defects in primordial germ cell migration.
SDF-1 (show CXCL12 Antibodies)/CXCR4 signaling is important for guiding retinal ganglion cell axons within the retina to the optic stalk to exit the retina.
chemokine (show CCL1 Antibodies) signaling contributes to both the olfactory placode assembly and the olfactory sensory neurons axon pathfinding in zebrafish
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
C-X-C chemokine receptor type 4
, SDF-1 receptor
, Stromal cell-derived factor 1 receptor
, chemokine (C-X-C motif) receptor 4
, chemokine (C-X-C) receptor 4
, chemokine receptor 4
, leukocyte-derived seven transmembrane domain receptor
, leukocyte-expressed seven-transmembrane-domain
, pre-B-cell-derived chemokine receptor
, stromal cell-derived factor 1 receptor
, CXC chemokine receptor
, chemokine receptor (LCR1)
, CD184 antigen
, leukocyte-derived seven-transmembrane-domain receptor
, lipopolysaccharide-associated protein 3
, neuropeptide Y receptor Y3
, seven transmembrane helix receptor
, seven-transmembrane-segment receptor, spleen
, C-X-C chemokine receptor type 4-B
, SDF-1 receptor B
, SDF-1 receptor-B
, Stromal cell-derived factor 1 receptor-B
, stromal cell-derived factor 1 receptor B
, chemokine receptor CXCR4
, CXC chemokine receptor 4