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The protein encoded by CSF3R is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. Additionally we are shipping CSF3R Kits (25) and CSF3R Proteins (21) and many more products for this protein.
Showing 10 out of 136 products:
Human Monoclonal CSF3R Primary Antibody for FACS - ABIN2659930
Ai, Druhan, Loveland, Avalos: G-CSFR ubiquitination critically regulates myeloid cell survival and proliferation. in PLoS ONE 2008
Show all 9 references for ABIN2659930
Human Monoclonal CSF3R Primary Antibody for FACS - ABIN2658442
Germeshausen, Skokowa, Ballmaier, Zeidler, Welte: G-CSF receptor mutations in patients with congenital neutropenia. in Current opinion in hematology 2008
Show all 9 references for ABIN2658442
Human Monoclonal CSF3R Primary Antibody for EIA, WB - ABIN114567
Pallud, Le Doussal, Pichon, Prudhomme, Hacene, Milgrom: Immunohistochemistry of pS2 in normal human breast and in various histological forms of breast tumours. in Histopathology 1993
Show all 3 references for ABIN114567
Human Polyclonal CSF3R Primary Antibody for EIA, FACS - ABIN951155
Germeshausen, Kratz, Ballmaier, Welte: RAS and CSF3R mutations in severe congenital neutropenia. in Blood 2009
Show all 2 references for ABIN951155
Human Polyclonal CSF3R Primary Antibody for IF (p), IHC (p) - ABIN742275
Tajima, Waki, Tsuchiya, Hoshi et al.: Granulocyte colony-stimulating factor-producing undifferentiated carcinoma of the colon mimicking a pulmonary giant cell carcinoma: a case showing overexpression of CD44 along with highly ... in International journal of clinical and experimental pathology 2014
Human Monoclonal CSF3R Primary Antibody for FACS - ABIN319850
Nicholson, Oates, Harpur, Ziemiecki, Wilks, Layton: Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. in Proceedings of the National Academy of Sciences of the United States of America 1994
CSF3R mutations, mechanisms of mutations, and their contributions to the myeloid malignancies (Review)
In conclusion, rhCSF3 can promote melanocyte proliferation through CSF3R without affecting tyrosinase (show TYR Antibodies) activity
CSF3R mutations are associated with congenital neutropenia.
The leukemogenic potential of G-CSFRIV is associated with the Stat5 (show STAT5A Antibodies)-dependent dysregulation of miR (show MLXIP Antibodies)-155 and the target genes of this miRNA.
No CSF3R mutations were found in cases of MDS (show PAFAH1B1 Antibodies), JMML or ET. The only mutation found in the CALR (show CALR Antibodies) gene was a frameshift (p.L367 fs) in one ET patient.
The SETBP1 (show SETBP1 Antibodies) and ASXL1 (show ASXL1 Antibodies) mutations have pathogenetic roles in CSF3R-mutated chronic neutrophilic leukemia.
CSF3R polymorphisms are associated with chronic neutrophilic leukemia.
CSF3R T618I mutation as a disease-specific marker of atypical CML post allo-SCT in two patients.
the incorporation of CSF3R mutation testing can be a useful point-of-care diagnostic to evaluate the presence of a clonal myeloid disorder, as well as providing the potential for genetically informed therapy.
study to see if the CSF3R p.T618I mutation was present in acute myelogenous leukemia (AML (show RUNX1 Antibodies)) and solid tumors of Korean patients; data revealed that CSF3R p.T618I mutation occurred in an AML (show RUNX1 Antibodies) with myelodysplasia-related changes and a refractory anemia with excess blasts in transformation
Thr (show TRH Antibodies)-615 and Thr (show TRH Antibodies)-618 sites of membrane-proximal mutations are part of an O-linked glycosylation cluster. Mutation at these sites prevents O-glycosylation of CSF3R and increases receptor dimerization.
Fbw7 (show FBXW7 Antibodies) together with GSK3beta (show GSK3b Antibodies) negatively regulates G-CSFR expression and its downstream signaling.
G-CSFR signaling interacts with retinoic acid receptors in the regulation of myeloid differentiation
Expression of truncated G-CSFR significantly shortens the latency of AML (show RUNX1 Antibodies) in a G-CSF (show CSF3 Antibodies)-dependent fashion and it is associated with a distinct AML (show RUNX1 Antibodies) presentation characterized by higher blast counts and more severe myelosuppression.
G-CSFR signals in bone marrow monocytic cells inhibit the production of trophic factors required for osteoblast lineage cell maintenance, ultimately leading to hematopoietic stem and progenitor cell mobilization.
Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF (show CSF3 Antibodies)-induced expansion of myeloid progenitor cells.
murine granulocyte colony-stimulating factor receptor binds to a low molecular weight ligand
Mice with truncated G-CSF (show CSF3 Antibodies) receptors have neutropenia, susceptibility to infection, and bone marrow maturation arrest similar to severe congenital neutropenic humans, suggesting a role of receptor truncation mutations in SCN (show SRI Antibodies) pathology.
COOH-terminal truncation mutants of G-CSF-R, found in severe congenital neutropenia, lack internalization motifs and are completely defective in both spontaneous and ligand-induced internalization.
activation of both the Flt-3 (show FLT3 Antibodies) and G-CSF (show CSF3 Antibodies) receptors provides a high degree of radioprotection to the hematopoietic progenitor cell and stem cell compartment.
GCSF (show CSF3 Antibodies)/GCSFR is a conserved signaling system for facilitating the production of multiple myeloid cell lineages, as well as for early myeloid cell migration.
The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia.
granulocyte colony-stimulating factor receptor
, colony stimulating factor 3 receptor (granulocyte)
, granulocyte colony-stimulating factor receptor-like
, CD114 antigen
, G-CSF receptor
, granulocyte stimulating factor receptor