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anti-Deoxycytidine Kinase (DCK) Antibodies

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Additionally we are shipping DCK Proteins (18) and DCK Kits (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DCK 1633 P27707
DCK 13178 P43346
DCK 79127 P48769
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Top anti-DCK Antibodies at antibodies-online.com

Showing 10 out of 101 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-DCK Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-DCK Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, IHC (p), IP, WB The anti-DCK Pab (ABIN391125) is used in Western blot to detect DCK in... Deoxycytidine kinase(DCK) immunoprecipitated from H460cells with 7.5ug... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using DCK ant... 100 μL Log in to see 9 Days
$302.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated FACS, WB HEK293T cells transfected with either RC210767 overexpress plasmid (Re... HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane... 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB HEK293T cells transfected with either RC210767 overexpress plasmid (Re... Anti-DCK mouse monoclonal antibody (ABIN2454431) immunofluorescent sta... 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, WB HEK293T cells transfected with either RC210767 overexpress plasmid (Re... Anti-DCK mouse monoclonal antibody (ABIN2454451) immunofluorescent sta... 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged DCK is approximately 0.3ng/... Western Blot detection against Immunogen (36.74 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged DCK is approximately 3ng/ml... Immunofluorescence of monoclonal antibody to DCK on HeLa cell. [antibo... 100 μg Log in to see 9 Days
$430.00
Details

DCK Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
,
Mouse (Murine) , , , ,

Rat (Rattus) , , , ,

Top referenced anti-DCK Antibodies

  1. Human Polyclonal DCK Primary Antibody for IF, IHC (p) - ABIN391125 : Hartford, Duan, Delaney, Mi, Kistner, Lamba, Huang, Dolan: Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity. in Blood 2009 (PubMed)
    Show all 3 references for ABIN391125

  2. Mouse (Murine) Polyclonal DCK Primary Antibody for IHC, WB - ABIN3022558 : van der Wilt, Kroep, Loves, Rots, Van Groeningen, Kaspers, Peters: Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver. in European journal of cancer (Oxford, England : 1990) 2003 (PubMed)
    Show all 3 references for ABIN3022558

  3. Chicken Polyclonal DCK Primary Antibody for WB - ABIN2784622 : Iyidogan, Lutz: Systematic exploration of active site mutations on human deoxycytidine kinase substrate specificity. in Biochemistry 2008 (PubMed)
    Show all 2 references for ABIN2784622

  4. Human Monoclonal DCK Primary Antibody for ELISA, WB - ABIN514896 : Funel, Giovannetti, Del Chiaro, Mey, Pollina, Nannizzi, Boggi, Ricciardi, Del Tacca, Bevilacqua, Mosca, Danesi, Campani: Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma. in Laboratory investigation; a journal of technical methods and pathology 2008 (PubMed)

  5. Human Monoclonal DCK Primary Antibody for IF, ELISA - ABIN514902 : Costantino, Witkiewicz, Kuwano, Cozzitorto, Kennedy, Dasgupta, Keen, Yeo, Gorospe, Brody: The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase. in Cancer research 2009 (PubMed)

More Antibodies against DCK Interaction Partners

Human Deoxycytidine Kinase (DCK) interaction partners

  1. recently described a human deoxycytidine kinase mutant (G12 (show TCF3 Antibodies)) that sensitizes cancer cell lines to treatment with gemcitabine. Here, starting from the G12 (show TCF3 Antibodies) variant, we identified a mutant that triggers even greater sensitisation to gemcitabine than G12 (show TCF3 Antibodies).

  2. RNA expression of deoxycytidine kinase (DCK), human equilibrative nucleoside transporter-1 (ENT1 (show SLC29A1 Antibodies)) and ribonucleotide reductase M1 (RRM1 (show RRM1 Antibodies)) were significantly higher and cytidine deaminase (CDA (show CDA Antibodies)) was significantly lower in ex vivo Ara (show FOXC1 Antibodies)-C sensitive samples.

  3. n the multivariate Cox (show COX8A Antibodies) regression analysis, we found that age at diagnosis, wild-type genotype of the CDA (show CDA Antibodies) A79C polymorphism, and wild-type genotype of the dCK C360G polymorphism were the most significant prognostic factors for predicting the risk of death

  4. results strongly suggest that (1) the E197K alteration in DCK causes inactivation of DCK, and that (2) loss of the normal E197 allele is the crucial mechanism in acquisition of gemcitabine resistance in the RMKN28 tumor cell line

  5. DCK rs12648166 and DCK rs4694362 SNPs were associated with hematologic toxicity (OR = 2.63, CI 95% = 1.37-5.04, P = 0.0036 and OR = 2.53, CI 95% = 1.34-4.80, P = 0.0044, respectively).

  6. These findings indicate that the decitabine metabolic pathway affects its therapeutic effects, lower hENT1 expression may induce primary resistance and down-regulated DCK expression may be related to secondary resistance.

  7. DCK expression levels are prognostic and had predictive value for sensitivity to 5-FU in pancreatic cancer.

  8. DCK could regulate the migration and invasion of fibroblast-like synoviocytes through AKT (show AKT1 Antibodies) pathway in rheumatoid arthritis patients.

  9. PP2A (show PPP2R4 Antibodies) constitutively dephosphorylates dCK in cells and negatively regulates its activity.

  10. Report genetic variation in deoxycytidine kinase and subsequent gemcitabine metabolism.

Mouse (Murine) Deoxycytidine Kinase (DCK) interaction partners

  1. Mutation of a single serine 74 residue has profound effects on murine T and B lymphocyte (show AKAP17A Antibodies) development, suggesting that post-translational regulation of dCK has a role in maintaining genomic stability during hematopoiesis.

  2. activating the dAdo-DCK-dATP pathway directly results in increased apoptosis in the lungs of mice with air-space enlargement and suggests a novel therapeutic target for the treatment of COPD (show ARCN1 Antibodies)

  3. Deoxycytidine kinase is a new regulator of hematopoietic integrity and lymphocyte quiescence and survival.

  4. The severe impact of dCK inactivation on lymphopoiesis was unexpected given that nucleoside salvage has been thought to play a limited, "fine-tuning" role in regulating deoxyribonucleotide triphosphate pools produced by the de novo pathway.

DCK Antigen Profile

Protein Summary

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.

Gene names and symbols associated with DCK

  • Deoxycytidine kinase (dck) antibody
  • deoxycytidine kinase, gene 2 (dck.2) antibody
  • deoxycytidine kinase (DCK) antibody
  • zgc:110540 (zgc:110540) antibody
  • Deoxycytidine kinase (FPV059) antibody
  • Deoxycytidine kinase (FPV151) antibody
  • deoxycytidine kinase (Dck) antibody
  • deoxycytidine kinase (dck) antibody
  • deoxycytidine kinase, gene 1 (dck.1) antibody
  • Dck antibody
  • dck1 antibody
  • dck2 antibody
  • wu:fc15f06 antibody
  • wu:fe11h12 antibody
  • wu:fj05e11 antibody
  • zgc:101771 antibody
  • zgc:109951 antibody

Protein level used designations for DCK

Deoxycytidine kinase , deoxycytidine kinase , deoxynucleoside kinase , deoxycytidine kinase 1 , deoxyribonucleoside kinase

GENE ID SPECIES
100196160 Salmo salar
446773 Xenopus laevis
549546 Xenopus (Silurana) tropicalis
100305233 Oncorhynchus mykiss
461273 Pan troglodytes
705040 Macaca mulatta
541538 Danio rerio
1486607 Fowlpox virus
1486699 Fowlpox virus
1633 Homo sapiens
13178 Mus musculus
474325 Danio rerio
422648 Gallus gallus
482188 Canis lupus familiaris
530642 Bos taurus
79127 Rattus norvegicus
496391 Xenopus laevis
Selected quality suppliers for anti-DCK (DCK) Antibodies
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