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Endoplasmic Reticulum Aminopeptidase 2 Proteins (ERAP2)

Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Additionally we are shipping Endoplasmic Reticulum Aminopeptidase 2 Antibodies (29) and Endoplasmic Reticulum Aminopeptidase 2 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ERAP2 64167 Q6P179
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Top Endoplasmic Reticulum Aminopeptidase 2 Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 20 to 21 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 11 to 13 Days

ERAP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,

Top referenced Endoplasmic Reticulum Aminopeptidase 2 Proteins

  1. Human ERAP2 Protein expressed in Human Cells - ABIN2003323 : Tanioka, Hattori, Masuda, Nomura, Nakayama, Mizutani, Tsujimoto: Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 references for ABIN2003323

More Proteins for Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) Interaction Partners

Human Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) interaction partners

  1. there is a significant association of ERAP2 with psoriatic arthritis and HLA-B27 negative psoriatic arthritis, while ERAP1 association is restricted only to HLA-B27 positive disease

  2. Increased expression of ERAP2 in GC-responders before therapy warrants further investigation into their role as potential predictors for the response to GC, and in the inflammatory process of rheumatoid arthritis.

  3. ERAP2 is associated with ankylosing spondylitis in HLA-B27 positive and HLA-B27 negative patients.

  4. ERAP2 might be associated with CLNM in PTMC.

  5. ERAP2 variation does not have a significant effect on PBMC intracellular and cell surface HLA-class I (show MICA Proteins) expression and heavy chain formation, markers of ER stress or inflammatory cytokine production.

  6. Studies indicate the critical role of M1 aminopeptidases ERAP1 (show ERAP1 Proteins), ERAP2 and NPEPPS (show NPEPPS Proteins) in immune-mediated diseases.

  7. The risk allele of the polymorphism near ERAP2 is strongly associated with birdshot chorioretinopathy.

  8. Data indicate that dimerization of endoplasmic reticulum aminopeptidases ERAP1 (show ERAP1 Proteins)/2 creates complexes with superior peptide-trimming efficacy.

  9. concerted aminoproteolytic activity of ERAP 1 (show ERAP1 Proteins) and ERAP2

  10. ERAP2 haplotype A is correlated with resistance to HIV-1 infection, possibly secondarily to its effect on antigen processing and presentation.

Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) Protein Profile

Protein Summary

Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 (MIM 606832) and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2\; MIM 190470) (Tanioka et al., 2003

Gene names and symbols associated with ERAP2

  • endoplasmic reticulum aminopeptidase 2 (ERAP2)
  • ERAP2 protein
  • L-RAP protein
  • LRAP protein

Protein level used designations for ERAP2

endoplasmic reticulum aminopeptidase 2 , leukocyte-derived arginine aminopeptidase , endoplasmic reticulum aminopeptidase 2-like

461959 Pan troglodytes
700118 Macaca mulatta
100402550 Callithrix jacchus
64167 Homo sapiens
488897 Canis lupus familiaris
513572 Bos taurus
100171433 Pongo abelii
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