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may play a role in D5 dopamine receptor signal transduction and renal sodium transport. Additionally we are shipping and many more products for this protein.
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Human Polyclonal GNA12 Primary Antibody for EIA, WB - ABIN360476
Suzuki, Nakamura, Mano, Kozasa: Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF. in Proceedings of the National Academy of Sciences of the United States of America 2003
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Chicken Polyclonal GNA12 Primary Antibody for WB - ABIN2785900
Jeske, So, Kelemen, Sukor, Willys, Bulmer, Gordon, Duffy, Stowasser: Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II. in Clinical and experimental pharmacology & physiology 2008
we conclude that Galpha12 protects HUVECs[ human umbilical vein endothelial cells ] from serum withdrawal-induced apoptosis by retaining miR (show MLXIP Antibodies)-155 expression.
RGS22 (show RGS22 Antibodies) acts as a tumor suppressor, repressing human pancreatic adenocarcinoma cell migration by coupling to GNA12/13.
preeclampsia is associated with decreased methylation of the GNA12 promoter
Data show that N-linked glycosylation of protease-activated receptor-1 (PAR1 (show F2R Antibodies)) at extracellular loop 2 (ECL2) controls G12 (show TCF3 Antibodies)/13 versus Gq G-proteins coupling specificity in response to thrombin (show F2 Antibodies) stimulation.
Significance of Galpha12 upregulation in liver tumor progression, implicating Galpha12 as an attractive therapeutic target.
Results show that RMP (show ABCA4 Antibodies) serves as a potent factor contributing to portal vein tumor thrombus by promoting IL-6 (show IL6 Antibodies) transcription.
A tyrosine residue at the C-terminus of the Galpha subunit plays an important role in controlling activation of G-protein coupled receptors.
Galpha12gep oncogene (show RAB1A Antibodies) inhibits FOXO1 (show FOXO1 Antibodies), which may result from the inhibition of FOXO1 (show FOXO1 Antibodies) de novo synthesis by miR (show MLXIP Antibodies)-135b in conjunction with MDM2 (show MDM2 Antibodies)-mediated destabilization of FOXO1 (show FOXO1 Antibodies).
CREB (show CREB1 Antibodies) is a critical signaling node in Lysophosphatidic acid-Lysophosphatidic acid receptor and Galpha12/gep proto-oncogene (show RAB1A Antibodies) stimulated oncogenic signaling in ovarian cancer cells.
Galpha12 drives oral squamous cell carcinoma invasion through the up-regulation of IL-6 (show IL6 Antibodies) and IL-8 (show IL8 Antibodies) cytokines.
Gpr56 (show GPR56 Antibodies) regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA (show RHOA Antibodies)
Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.
Selective inhibition of G12 (show TCF3 Antibodies)/13 signaling in macrophages can augment atheroprotective B-cell populations and ameliorate atherosclerosis.
results suggest that KIM-1 (show HAVCR1 Antibodies) is an endogenous protective mechanism against renal ischemia-reperfusion injury through inhibition of Galpha12.
Pkd1 (show PKD1 Antibodies) mutation or deletion leads to the activation of Galpha12, which promotes the maturation of ADAM10 (show ADAM10 Antibodies) that increases the shedding of E-cadherin (show CDH1 Antibodies) in kidney epithelial cells.
Galpha12 may play an important role in promoting membrane trafficking and exocytosis for basal and thrombin (show F2 Antibodies)-induced vWF (show VWF Antibodies) secretion, in a process involving SNAP, Galpha12/13 and Galphaq (show GNAQ Antibodies)/11
Data indicate that Pyk2 (show PTK2B Antibodies) is a common signaling effector downstream of both G12 (show TCF3 Antibodies)/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.
PRR5L (show PRR5L Antibodies) degradation promotes mTORC2 (show CRTC2 Antibodies)-mediated PKC-delta (show PKCd Antibodies) phosphorylation and cell migration downstream of Galpha12 in fibroblasts and pulmonary fibrosis.
Expression analysis reveals that production of 5-HT7 (show HTR7 Antibodies) and Galpha12 proteins in the hippocampus undergoes strong regulation with a pronounced transient increase during early postnatal stages.
that Galpha (show SUCLG1 Antibodies)(i2)-induced signaling can act as a counterbalance to MuRF1 (show TRIM63 Antibodies)-mediated atrophy, indicating that receptors that act through Galpha (show SUCLG1 Antibodies)(i2) might represent potential targets for preventing skeletal muscle wasting.
Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn (show FYN Antibodies) kinase
may play a role in D5 dopamine receptor signal transduction and renal sodium transport
G-protein subunit alpha-12
, g alpha-12
, guanine nucleotide-binding protein subunit alpha-12
, guanine nucleotide binding protein, alpha 12
, Galpha 12
, guanine nucleotide binding protein (G protein) alpha 12