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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Additionally we are shipping Histone Deacetylase 5 Kits (10) and Histone Deacetylase 5 Proteins (6) and many more products for this protein.
Showing 10 out of 169 products:
Human Monoclonal HDAC5 Primary Antibody for IF, WB - ABIN393805
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010
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Human Polyclonal HDAC5 Primary Antibody for ChIP, WB - ABIN2668266
Basile, Mantovani, Imbriano: DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines. in The Journal of biological chemistry 2006
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Human Polyclonal HDAC5 Primary Antibody for IHC (p), IP - ABIN127240
Wang, Bertos, Vezmar, Pelletier, Crosato, Heng, Thng, Han, Yang: HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. in Molecular and cellular biology 1999
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Human Polyclonal HDAC5 Primary Antibody for IHC (p), WB - ABIN196932
Döppler, Storz, Li, Comb, Toker: A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D. in The Journal of biological chemistry 2005
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Human Polyclonal HDAC5 Primary Antibody for IP, IHC - ABIN223300
Yamaguchi, Chakraborty, Pasek, Molkentin, Meissner: Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. in American journal of physiology. Heart and circulatory physiology 2011
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Human Polyclonal HDAC5 Primary Antibody for IHC (p), WB - ABIN197340
McKinsey, Zhang, Lu, Olson: Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. in Nature 2000
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HDAC5 and HDAC6 (show HDAC6 Antibodies) were highly expressed in melanoma cells but exhibited low expression levels in normal skin cells.
Formononetin-combined therapy may enhance the therapeutic efficacy of doxorubicin in glioma cells by preventing EMT (show ITK Antibodies) through inhibition of HDAC5.
These results suggest a strong regulatory function of HDAC5 in the pro-inflammatory response of macrophages.
In erythroid cells, pull down experiments identified the presence of a novel complex formed by HDAC5, GATA1, EKLF and pERK which was instead undetectable in cells of the megakaryocytic lineage.
Data reveal a novel role of HDAC5 in modulating the KLF2 (show KLF2 Antibodies) transcriptional activation and eNOS (show NOS3 Antibodies) expression.
Studied phosphorylation sites within functional HDAC5 domains, including the deacetylation domain (DAC (show AADAC Antibodies), Ser755), nuclear export signal (NES (show NES Antibodies), Ser1108), and an acidic domain (AD, Ser611).
mRNA and protein levels of HDAC5 were up-regulated in human hepatocellular carcinoma.
HDAC5 promoted the Six1 (show SIX1 Antibodies) expression.
In C2C12 myoblasts, recombinant human HDAC5 phosphorylation by PKD (show PRKD1 Antibodies) regulated the expression of diverse metabolic genes and glucose metabolism.
findings show N-Myc (show MYCN Antibodies) upregulated HDAC5 expression in neuroblastoma (show ARHGEF16 Antibodies) cells; HDAC5 repressed NEDD4 (show NEDD4 Antibodies) gene expression,increased Aurora A (show AURKA Antibodies) gene expression and consequently upregulated N-Myc protein (show MYCN Antibodies) expression;data identify HDAC5 as a novel co-factor in N-Myc (show MYCN Antibodies) oncogenesis
It protects neurons from toxicity of prion (show PRNP Antibodies) peptide, and that this protection occurs at through the regulation of the PI3k-Akt (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies) axis.
mass spectrometry-based quantitative comparison of acetylated peptides from wild-type vs HDAC6 (show HDAC6 Antibodies) knockout mice allowed to identify six new deacetylation sites possibly mediated by HDAC6 (show HDAC6 Antibodies).
We therefore tested that reducing HDAC6 (show HDAC6 Antibodies) levels by genetic manipulation would attenuate early cognitive and behavioral deficits in R6/1 mice
HDAC6 plays an important role in the function of CMA pathway under the HI stress induced by SCI and it may be a potential therapeutic target in acute SCI model.
inhibition of HDAC5 differentially regulates ghrelin (show GHRL Antibodies) and NUCB2/ nesfatin-1 (show NUCB2 Antibodies) expression by enhancing the acetylation and phosphorylation of Raptor (show RPTOR Antibodies), which subsequently suppress mTORC1 signaling
Results suggest a role for Hdac5 and Sirt2 (show SIRT2 Antibodies) in neuronal adaptations induced by chronic stress and antidepressant treatment and highlight the therapeutic potential of these targets in the treatment of depression
loss of HDAC5 weakens Treg suppressive function and iTreg formation, as well as IFN-gamma (show IFNG Antibodies) production in CD8 (show CD8A Antibodies)+ T cells. Mice lacking HDAC5 do not develop spontaneous illness and do not have enhanced anti-tumor immunity.
functional loss or suppression of the tumor suppressor HDAC6 (show HDAC6 Antibodies) is caused by induction of miR (show MLXIP Antibodies)-221 through coordinated JNK/c-Jun- and NF-kappaB (show NFKB1 Antibodies)-signaling pathways during liver tumorigenesis
Hyperacetylation of Hsp90 (show HSP90 Antibodies) is a predictor and causal molecular determinant of stress resilience in mice. Brain-penetrant histone deacetylase 6 (show HDAC6 Antibodies) inhibitors increase Hsp90 (show HSP90 Antibodies) acetylation and modulate GR chaperone dynamics.
Soluble beta-amyloid disrupts actin and microtubule dynamics via activation of RhoA (show RHOA Antibodies) and inhibition of histone deacetylase 6 (show HDAC6 Antibodies) in cultured hippocampal neurons.
Protein kinase D-HDAC5 pathway plays an important role in VEGF regulation of gene transcription and angiogenesis
Regulation of flowering time by the histone deacetylase HDA5
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
histone deacetylase 5
, antigen NY-CO-9
, histone deacetylase 4
, histone deacetylase mHDA1
, histone deacetylase mHDA2
, scurfy candidate 6