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IKAROS Family Zinc Finger 1 (Ikaros) Proteins (IKZF1)

IKZF1 encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. Additionally we are shipping IKZF1 Antibodies (136) and IKZF1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IKZF1 22778  
Rat IKZF1 IKZF1 305501  
IKZF1 10320 Q13422
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Top IKZF1 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

IKZF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) Interaction Partners

Mouse (Murine) IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) interaction partners

  1. These results indicate that Ikaros is required to limit B1 cell homeostasis in the adult.

  2. These results suggest that Ikaros functions as a negative regulator of follicular B cell activation (show BLNK Proteins).

  3. Ikaros functions as a guardian of B-1 lymphoid pattern, and that its absence directs the differentiation of B-1 cells into phagocytes.

  4. Ikaros is a fundamental regulator of PRC2 function in developing T cells.

  5. Ikaros/Ets1 binding has a role on Ikzf1 expression that is exerted at least through its promoter

  6. deletions on chromosomes 4 and 11 affecting Cdkn2a and Ikaros are a prominent feature of young adult irradiation-induced T-cell lymphoma.. tumors arising after irradiation suffer a second hit in Pten by mis (show AMH Proteins)-segregation or recombination

  7. Murine pancreatic adenocarcinoma reduces Ikaros expression and disrupts T cell homeostasis

  8. The Ikaros family of DNA-binding proteins are critical regulators of lymphocyte differentiation. (Review)

  9. mice with targeted deletion of the fourth DNA-binding zinc finger of the transcription factor Ikaros had increased IL-22 (show IL22 Proteins)-producing, but not IL-17 (show IL17A Proteins)-producing, CD4 (show CD4 Proteins)(+) T cells in the gut (show GUSB Proteins).

  10. by repressing autocrine IL-2 (show IL2 Proteins) production, Ikaros ensures that naive CD8 (show CD8A Proteins)(+) T cells remain dependent on licensing by APCs (show APCS Proteins) and CD4 (show CD4 Proteins)(+) T cells, and it may therefore act as a cell-intrinsic safeguard against inappropriate CTL differentiation

Human IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) interaction partners

  1. variants within IKZF1, ARID5B (show ARID5B Proteins), and CEBPE (show CEBPE Proteins) were associated with pediatric ALL risks.

  2. FISH studies showed false-negative results in 10, 40, and 28% of the samples tested for the IKZF1,PAX5 (show PAX5 Proteins), and CDKN2A/B gene deletions, respectively. The PAX5 (show PAX5 Proteins) and IKZF1 abnormalities are highly specific to B (show TDO2 Proteins)-ALL and can be used as diagnostic markers

  3. The impact of IKZF1 polymorphisms on childhood ALL risk.

  4. Genotypic and allelic frequencies differed significantly between cases and controls at IKZF1-rs4132601 (p=0.039, p=0.015) and ARID5B (show ARID5B Proteins)-rs10821936 (p=0.028, p=0.026).

  5. These data suggest IKZF1 deletion may be a useful prognostic variable in adults with common B-cell ALL, especially in persons without BCR (show BCR Proteins)-ABL1 (show ABL1 Proteins) and those receiving chemotherapy-only.

  6. Data indicate an oncogenic role for an Ikaros protein/MYCBP2 protein/proto-oncogene (show RAB1A Proteins) protein c-MYC (show MYC Proteins) axis in adult acute lymphoblastic leukemia (ALL), providing a mechanism of target therapies that activate Ikaros in ALL.

  7. The anti-PEL effects of IMiDs involved cereblon (show CRBN Proteins)-dependent suppression of IRF4 (show IRF4 Proteins) and rapid degradation of IKZF1, but not IKZF3 (show IKZF3 Proteins). Small hairpin RNA-mediated knockdown of MYC (show MYC Proteins) enhanced the cytotoxicity of IMiDs

  8. A novel, non-canonical splice variant of the Ikaros gene (Ik11) is aberrantly expressed in B-cell lymphoproliferative disorders.

  9. the presented data suggest a mechanism through which Ikaros and HDAC1 (show HDAC1 Proteins) regulate the epigenetic signature in leukemia: via regulation of JARID1B (show KDM5B Proteins) transcription.

  10. IKZF1 deletions were detected in 28.7% B-ALL patients, were more common in BCR-ABL (show ABL1 Proteins) positive and adult B-ALL, and correlated with higher induction failure

IKZF1 Protein Profile

Protein Summary

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

Gene names and symbols associated with IKZF1

  • IKAROS family zinc finger 1 (Ikzf1)
  • IKAROS family zinc finger 1 (Ikaros) (IKZF1)
  • IKAROS family zinc finger 1 (Ikaros) (ikzf1)
  • Ikaros homolog (ikaros)
  • 5832432G11Rik protein
  • hIk-1 protein
  • hlk-1 protein
  • Hs.54452 protein
  • IK1 protein
  • ikaros protein
  • ikzf1 protein
  • LyF-1 protein
  • LYF1 protein
  • mKIAA4227 protein
  • PRO0758 protein
  • RGD1562979 protein
  • Zfpn1a1 protein
  • znfn1a1 protein

Protein level used designations for IKZF1

DNA-binding protein Ikaros , ikaros family zinc finger protein 1 , lymphoid transcription factor LyF-1 , zinc finger protein subfamily 1A, 1 , zinc finger protein, subfamily 1A, 1 (Ikaros) , CLL-associated antigen KW-6 , Ikaros (zinc finger protein) , Ikaros transcription factor , KAROS family zinc finger 1 (Ikaros)

22778 Mus musculus
305501 Rattus norvegicus
10320 Homo sapiens
395974 Gallus gallus
483231 Canis lupus familiaris
541154 Bos taurus
30177 Danio rerio
100136762 Oncorhynchus mykiss
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