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ITGA2B encodes integrin alpha chain 2b. Additionally we are shipping Integrin Alpha2b Kits (16) and Integrin Alpha2b Proteins (11) and many more products for this protein.
Showing 10 out of 515 products:
Mouse (Murine) Monoclonal CD41 Primary Antibody for FACS - ABIN320117
NOYES, DOMM, WILLSLC: Regulation of erythropoiesis. I. Erythropoietin assay as a clinical tool. in Blood 1970
Show all 9 references for ABIN320117
Mouse (Murine) Monoclonal CD41 Primary Antibody for FACS - ABIN320114
Nieswandt, Echtenacher, Wachs, Schröder, Gessner, Schmidt, Grau, Männel: Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice. in Blood 1999
Show all 4 references for ABIN320114
Human Monoclonal CD41 Primary Antibody for FACS - ABIN638432
Debili, Robin, Schiavon, Letestu, Pflumio, Mitjavila-Garcia, Coulombel, Vainchenker: Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates. in Blood 2001
Show all 4 references for ABIN638432
Human Polyclonal CD41 Primary Antibody for IF (p), IHC (p) - ABIN748358
Mei, Yin, Jin, He, Yin: The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. in Endocrinology 2013
Show all 3 references for ABIN748358
Mouse (Murine) Monoclonal CD41 Primary Antibody for FACS - ABIN320115
Zanzinger, Schellack, Nausch, Cerwenka: Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes. in Immunology 2009
Show all 2 references for ABIN320115
Human Monoclonal CD41 Primary Antibody for FACS - ABIN118660
Michelson, Page, Casey, Trucksess, Love, Milstien, Wilson, Massaquoi, Crofford, Hallett: An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan. in The Journal of rheumatology 1995
Show all 2 references for ABIN118660
Human Monoclonal CD41 Primary Antibody for FACS, IHC - ABIN1724823
Nurden, Fiore, Nurden, Pillois: Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models. in Blood 2011
Show all 2 references for ABIN1724823
Human Monoclonal CD41 Primary Antibody for FACS - ABIN118657
Hornby, Brown, Wilkinson, Mattock, Authi: Activation of human platelets by exposure to a monoclonal antibody, PM6/248, to glycoprotein IIb-IIIa. in British journal of haematology 1992
Show all 2 references for ABIN118657
ITGA2b (show ITGA2B Antibodies) expression increases in response to immunization, raising the possibility that heterogeneous ITGA2b (show ITGA2B Antibodies) levels reflect variation in exposure to activation signals.
Thrombopoietin (show THPO Antibodies)/MPL (show MPL Antibodies) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 (show MECOM Antibodies) leukemia.
Direct binding of kindlin-3 (show FERMT3 Antibodies) to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation.
ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.
reduction of talin-beta3 integrin (show ITGB3 Antibodies) binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding
deficiency of Dok-2 leads to dysregulated integrin alphaIIbbeta3-dependent cytosolic calcium flux and phosphatidylinositol(3,4)P2 accumulation.
Platelets lacking ERp57 (show PDIA3 Antibodies) have defective activation of the alphaIIbbeta3 integrin and platelet aggregation. The defect in aggregation was corrected by the addition of exogenous ERp57 (show PDIA3 Antibodies), implicating surface ERp57 (show PDIA3 Antibodies) in platelet aggregation.
Data indicate that Pyk2 (show PTK2B Antibodies) is a common signaling effector downstream of both G12 (show TCF3 Antibodies)/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.
These results identify a novel pathway of integrin alphaIIbbeta3 outside-in signaling and recognize the tyrosine kinase Pyk2 as a major regulator of platelet adhesion and spreading on fibrinogen.
identified Hic-5 (show TGFB1I1 Antibodies) as a novel and specific regulatory factor for thrombin (show F2 Antibodies)-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice.
Case Report: Reduced binding of mutant FLNa (show FLNA Antibodies) to beta3 and the facilitated recruitment of talin by beta3 on platelet stimulation, explaining the increased alphaIIbbeta3 activation and the ensuing gain-of-platelet functions.
Mechanistic basis for the binding of fibrinogen-derived RGD- and AGDV-peptides to the platelet integrin alphaIIb-beta3 has been described.
the contribution of PAR1 (show MARK2 Antibodies) and PAR4 (show PAWR Antibodies) to thrombin (show F2 Antibodies)-mediated activation of the platelet fibrin receptor (GPIIbIIIa), is reported.
The most common HPA (show HPSE Antibodies) genotypes among Saudis were HPA-1 (show HPSE Antibodies) a + b- (75%), HPA-2 (show HPSE2 Antibodies) a + b- (62%), HPA-3 a + b- (51.5%), HPA (show HPSE Antibodies)-4 a + b- (99%), HPA-5 (show ITGA2 Antibodies) a + b- (76.5%), HPA (show HPSE Antibodies)-6 a + b- (100%) and HPA (show HPSE Antibodies)-15 a + b + (50%). The prevalent allele among the HPA (show HPSE Antibodies) systems was (a), except in the HPA (show HPSE Antibodies)-15 system where the (b) allele was found in 52% of the subjects.
Integrin alpha-IIb (show ITGA2B Antibodies) beta-3 dependent ERK (show EPHB2 Antibodies) signaling is regulated by Src (show SRC Antibodies) and Rho kinases in both Leu33 and Pro33 polymorphic isoforms.
Data suggest that CD41 and CD45 (show PTPRC Antibodies) expression marked the onset of haemangioblastoma (HB) neovascularisation and the stepwise development of the angioformative period, and also the underlying therapeutic targets of anti-vascular treatment.
ITGA2B (show ITGA2B Antibodies) and ITGA8 have roles in prognosis in clear cell renal cell carcinoma (show MOK Antibodies) patients
Thirteen variants in the ITGA2B (show ITGA2B Antibodies) locus and 29 variants in the ITGB3 (show ITGB3 Antibodies) locus were identified.
This study shows correlation of blood clot (show TXNDC17 Antibodies) stiffness with platelet integrin alpha-IIb (show ITGA2B Antibodies) beta3 activity, aspirin usage, and transfusion risk in cardiopulmonary bypass patients.
Data show that immune thrombocytopenia (ITP (show ITPA Antibodies)) is an autoimmune bleeding disorder characterized by low platelet count and presence of IgG autoantibodies to platelet surface glycoproteins, such as alpha IIbbeta3 integrins.
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
, GPalpha IIb
, alpha IIb
, integrin alpha-IIb
, platelet glycoprotein IIb of IIb/II Ia complex
, platelet membrane glycoprotein IIb
, platelet fibrinogen receptor, alpha subunit
, platelet-specific antigen BAK