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Interleukin 10 Receptor, alpha Proteins (IL10RA)

The protein encoded by IL10RA is a receptor for interleukin 10. Additionally we are shipping IL10RA Antibodies (211) and IL10RA Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IL10RA 3587 Q13651
IL10RA 16154 Q61727
Rat IL10RA IL10RA 117539  
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Top IL10RA Proteins at

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Human Cells Rhesus Monkey Fc Tag 100 μg Log in to see 20 to 21 Days
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
HOST_Baculovirus infected Insect Cells Human His tag   10 μg Log in to see 5 Days

IL10RA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
Mouse (Murine) ,
, ,

More Proteins for Interleukin 10 Receptor, alpha (IL10RA) Interaction Partners

Human Interleukin 10 Receptor, alpha (IL10RA) interaction partners

  1. results suggest that IL10 (show IL10 Proteins)-mediated inhibition of autophagy is facilitated by the cross talk between STAT3 (show STAT3 Proteins), AKT (show AKT1 Proteins), and mTOR (show FRAP1 Proteins); in other words, the IL10 (show IL10 Proteins)-IL10R-STAT3 (show STAT3 Proteins) and IL10 (show IL10 Proteins)-AKT (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) pathways.

  2. genetic association study in cohort of infants/children: Data suggest perianal fistulas are exhibited in patients with very early-onset inflammatory bowel disease with IL10 (show IL10 Proteins) receptor mutations (IL10RA/B); prognosis and response to treatment are poor.

  3. IL-10Ralpha expression is post-transcriptionally regulated by miR (show MLXIP Proteins)-15a, miR (show MLXIP Proteins)-185, and miR (show MLXIP Proteins)-211 in melanoma

  4. We also observed that BM-MSCs upregulated IL-10 (show IL10 Proteins) secretion as well as the expression of its receptor CD210 on T cells, thus creating a loop favoring the expansion of IL-10 (show IL10 Proteins)-producing T cells

  5. SNP3 polymorphism is associated with myocardial infarction; may generate some conformational rearrangements of the IL-10R1 receptor domain which affects IL-10 (show IL10 Proteins) complex binding and alters its downstream signal

  6. High IL10RA expression is associated with diffuse large B-cell lymphoma.

  7. Data suggest that, compared with monocytes and macrophages, myeloid dendritic cells partially escape from IL-10 (show IL10 Proteins)'s inhibitory mechanisms by downregulating IL-10R1.

  8. Inflammatory bowel disease (IBD) in infancy is phenotypically and genetically different disease entity from adult-onset or older child-onset IBD. It has a strong association with IL-10 (show IL10 Proteins) receptor gene.

  9. IL10R1 loss-of-function A536/S138G polymorphism may contribute to recurrent pregnancy loss pathogenesis

  10. Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation.

Mouse (Murine) Interleukin 10 Receptor, alpha (IL10RA) interaction partners

  1. loss of IL-10R signaling impaired the generation and function of anti-inflammatory intestinal and bone-marrow-derived macrophages and their ability to secrete IL-10 (show IL10 Proteins).

  2. loss of IL-10 (show IL10 Proteins) receptor expression impaired the critical conditioning of monocyte-derived macrophages and resulted in spontaneous development of severe colitis.

  3. Recent findings review how IL10 (show IL10 Proteins)- and IL10R-dependent signaling modulates innate and adaptive immune responses in the murine intestine.

  4. Treatment of mice with rIFN-gamma was sufficient to drive expression of IL-10R1 in the colonic epithelium. Intestinal epithelial-specific IL-10R1-null mice were more susceptible to DSS (show PMP22 Proteins) colitis associated with increased intestinal permeability.

  5. Inhibition of IL-10R signaling during bacillus Calmette-Guerin (BCG (show SLC11A1 Proteins)) vaccination increases and balances IFN-gamma (show IFNG Proteins) and IL-17A (show IL17A Proteins) responses in favor of the host.

  6. IL-10R subunit-alpha signaling plays a key role in the development as well as B-cell help function of T (follicular helper) cells in vitro and in vivo.

  7. showed here that IL-17A (show IL17A Proteins)-producing CD4 (show CD4 Proteins)+ T cells expressed interleukin-10 receptor alpha (IL-10Ralpha) in vivo

  8. Data show that, in an IL-10 (show IL10 Proteins)-dependent LPS (show TLR4 Proteins) model of endotoxemia, dampening of the immune response requires expression of IL-10R1 in monocytes/macrophages and/or neutrophils but not in T cells nor B cells.

  9. reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor (show IL10RB Proteins) antibody

  10. Immunocytochemistry data shows that the region of the adrenal gland responsible for the vast majority of corticosterone synthesis, the zona fasciculata, predominantly expresses the IL-10 (show IL10 Proteins) receptor 1.

IL10RA Protein Profile

Protein Summary

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

Gene names and symbols associated with IL10RA

  • interleukin 10 receptor, alpha (IL10RA)
  • interleukin 10 receptor, alpha (Il10ra)
  • AW553859 protein
  • CD210 protein
  • CD210a protein
  • CDw210 protein
  • CDw210a protein
  • HIL-10R protein
  • IL-10R1 protein
  • Il10r protein
  • IL10R1 protein
  • IL10RA protein
  • mIL-10R protein

Protein level used designations for IL10RA

interleukin 10 receptor 1 , interleukin-10 receptor subunit alpha , interleukin 10 receptor, alpha , interleukin-10 receptor subunit alpha-like , IL-10 receptor subunit alpha , IL-10R subunit 1 , IL-10R subunit alpha , IL-10RA , interleukin-10 receptor alpha chain , interleukin-10 receptor subunit 1 , IL-10R1

419771 Gallus gallus
451580 Pan troglodytes
610823 Canis lupus familiaris
704383 Macaca mulatta
100396693 Callithrix jacchus
100436549 Pongo abelii
100469546 Ailuropoda melanoleuca
3587 Homo sapiens
16154 Mus musculus
100525654 Sus scrofa
513478 Bos taurus
117539 Rattus norvegicus
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