You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Kruppel-Like Factor 1 (erythroid) (KLF1) Antibodies

KLF1 encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. Additionally we are shipping KLF1 Proteins (4) and KLF1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KLF1 10661 Q13351
KLF1 16596  
KLF1 304666  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-KLF1 Antibodies at antibodies-online.com

Showing 10 out of 68 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KLF1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB KLF1 Antibody (C-term) (ABIN658420) western blot analysis in NCI-H292 cell line lysates (35 µg/lane). This demonstrates the KLF1 antibody detected the KLF1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KLF1 Antibody Titration: 2.5ug/mlPositive Control: K562 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated FACS, IHC, ELISA, WB 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Cow Goat Un-conjugated ChIP   0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated ELISA, WB KLF1 monoclonal antibody (M02), clone 4E10 Western Blot analysis of KLF1 expression in K-562 Detection limit for recombinant GST tagged KLF1 is approximately 0.1ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB WB Image Sample (100ug of whole cell lysate) A: 293T (mock) B: 293T transfected KLF1 antibody diluted at 1:2000 100 μL Log in to see 2 to 3 Days
$292.60
Details

KLF1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
, ,
,
, , , , ,
Mouse (Murine) , , ,
, ,
,
, , , , ,
Rat (Rattus) ,
,

Top referenced anti-KLF1 Antibodies

  1. Cow (Bovine) Polyclonal KLF1 Primary Antibody for ChIP - ABIN374197 : Singleton, Lau, Fairweather, Burton, Wilson, Parsons, Richardson, Trakarnsanga, Brady, Anstee, Frayne: Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes. in Blood 2011 (PubMed)
    Show all 4 references for ABIN374197

  2. Human Polyclonal KLF1 Primary Antibody for WB - ABIN658420 : Borg, Papadopoulos, Georgitsi, Gutiérrez, Grech, Fanis, Phylactides, Verkerk, van der Spek, Scerri, Cassar, Galdies, van Ijcken, Ozgür, Gillemans, Hou, Bugeja, Grosveld, von Lindern, Felice, Patrinos, Philipsen: Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin. in Nature genetics 2010 (PubMed)
    Show all 2 references for ABIN658420

  3. Human Monoclonal KLF1 Primary Antibody for FACS, IHC - ABIN1724828 : Zhou, Liu, Sun, Pawlik, Townes: KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching. in Nature genetics 2010 (PubMed)
    Show all 2 references for ABIN1724828

  4. Human Monoclonal KLF1 Primary Antibody for ELISA, WB - ABIN524111 : Akgül, Lin, Ou Yang, Chen, Lu, Chen, Kikuchi, Chen, Tu: Garlic accelerates red blood cell turnover and splenic erythropoietic gene expression in mice: evidence for erythropoietin-independent erythropoiesis. in PLoS ONE 2011 (PubMed)

  5. Cow (Bovine) Polyclonal KLF1 Primary Antibody for WB - ABIN2777609 : Bieker: Probing the onset and regulation of erythroid cell-specific gene expression. in The Mount Sinai journal of medicine, New York 2005 (PubMed)

  6. Human Polyclonal KLF1 Primary Antibody for ELISA, WB - ABIN184728 : Pandya, Townes: Basic residues within the Kruppel zinc finger DNA binding domains are the critical nuclear localization determinants of EKLF/KLF-1. in The Journal of biological chemistry 2002 (PubMed)

  7. Cow (Bovine) Polyclonal KLF1 Primary Antibody for WB - ABIN2777325 : Quadrini, Gruzglin, Bieker: Non-random subcellular distribution of variant EKLF in erythroid cells. in Experimental cell research 2008 (PubMed)

More Antibodies against KLF1 Interaction Partners

Human Kruppel-Like Factor 1 (erythroid) (KLF1) interaction partners

  1. a broad range of hitherto unrelated human red cell disorders are caused by variants in KLF1, a master regulator of erythropoiesis, which were previously considered to be extremely rare causes of human genetic disease [review]

  2. results suggest that KLF1 directly regulates the beta-globin gene, but probably has less direct impact on expression of the gamma-globin gene in fetal erythroblasts

  3. A KLF1-targeted promoter-reporter assay showed that the two mutations reduce the expression of the HBB (show HBB Antibodies), BCL11A (show BCL11A Antibodies), and CD44 (show CD44 Antibodies) genes involved in erythropoiesis.

  4. erythrocyte lineage enforces exclusivity through upregulation of EKLF and its lineage-specific cytokine receptor (show EBI3 Antibodies) (EpoR (show EPOR Antibodies)) while inhibiting both FLI-1 (show FLI1 Antibodies) and the receptor TpoR (show MPL Antibodies) (also known as MPL (show MPL Antibodies)) for the opposing megakaryocyte lineage

  5. Studies indicate that Kruppel-like factor 1 (KLF1) mutations have been associated with severe hematologic disorders.

  6. a successful induction of gamma-globin (show HBG1 Antibodies) includes a reduction in BCL11A (show BCL11A Antibodies), KLF1 and TAL1 (show TAL1 Antibodies) expression.

  7. The study identified the DEK (show DEK Antibodies) oncoprotein as a critical factor that interacts with an essential upstream enhancer element of the EKLF promoter and exerts a positive effect on EKLF levels.

  8. Here we describe a Japanese patient with mild beta-thalassemia with an intact beta-globin (show HBB Antibodies) gene but a new missense mutation of c.947G > A or p.C316Y in the KLF1 gene which is strongly associated with the expression of the beta-globin (show HBB Antibodies) gene.

  9. The patient with the p.F182L variant (KLF1: c.544T > C) had noticeably high Hb A2 levels (7.6%), consistent with the phenotypic effect of several previously characterized KLF1 mutations in the same exonic region.

  10. These results indicate that KLF1 plays a role in facilitating and/or stabilizing GATA-1 (show GATA1 Antibodies) and TAL1 (show TAL1 Antibodies) occupancy in the erythroid genes, contributing to the generation of active chromatin structure such as histone acetylation and chromatin looping

Mouse (Murine) Kruppel-Like Factor 1 (erythroid) (KLF1) interaction partners

  1. Point mutations in the erythroid transcription factor, Klf1: one mutation, D11 generates a stop codon in the zinc finger domain and a homozygous null phenotype; another mutation, D45, generates an amino acid transversion (H350R) within a linker between zinc fingers two and three.

  2. Data indicate that PIAS3 (protein inhibitor of activated STAT3 (show PIAS3 Antibodies)) interaction modulates EKLF (erythroid Kruppel-like factor) activity in a promoter-dependent and SUMO-independent manner.

  3. Hemin-induced expression of PlGF (show PGF Antibodies) is abolished in EKLF-deficient erythroid cells but rescued by conditional expression of EKLF.

  4. HIRA (show HIRA Antibodies) is not only critical for beta-globin (show HBB Antibodies) expression but is also required for activation of the erythropoietic regulators EKLF and GATA binding protein 1 (GATA1).

  5. KLF1 and KLF2 (show KLF2 Antibodies) coordinately regulate embryonic erythroid precursor maturation through the regulation of multiple homeostasis-associated genes.

  6. EKLF mRNA has exon skipping only in primary tissues. The splice variant is at a low level in embryonic and adult erythroid cells, and in terminal differentiation. The truncated protein partially encodes a non-erythroid Kruppel-like factor AA sequence.

  7. Dok2 is able to control Klf1 expression by transcriptional regulation through directly binding to its promoter region.

  8. EKLF plays a coordinating role between two different cell types whose interaction provides the optimal environment to generate a mature red blood cell

  9. the regulatory mechanisms of the nuclear import of EKLF, which may also be utilized in the nuclear import of other factors

  10. Similar to its role at the beta-globin (show HBB Antibodies) promoter, KLF1 induces factor recruitment and chromatin changes at the Alad1b promoter in a temporally-specific manner

KLF1 Antigen Profile

Protein Summary

This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.

Gene names and symbols associated with KLF1

  • Kruppel-like factor 1 (erythroid) (KLF1) antibody
  • Kruppel-like factor 1 (erythroid) (Klf1) antibody
  • Eklf antibody
  • HBFQTL6 antibody
  • INLU antibody
  • KLF1 antibody
  • Nan antibody

Protein level used designations for KLF1

Kruppel-like factor 1 (erythroid) , Krueppel-like factor 1 , erythroid Kruppel-like factor , erythroid krueppel-like transcription factor , erythroid-specific transcription factor EKLF , monoclonal antibody A3D8 , erythroid transcription factor , neonatal anemia

GENE ID SPECIES
424577 Gallus gallus
468741 Pan troglodytes
100599870 Nomascus leucogenys
10661 Homo sapiens
100174958 Sus scrofa
784295 Bos taurus
16596 Mus musculus
304666 Rattus norvegicus
484924 Canis lupus familiaris
Selected quality suppliers for anti-KLF1 (KLF1) Antibodies
Did you look for something else?