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Melanocyte Stimulating Hormone Receptor Proteins (MSHR)

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). Additionally we are shipping Melanocyte Stimulating Hormone Receptor Antibodies (50) and Melanocyte Stimulating Hormone Receptor Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MSHR 17199 Q01727
MSHR 4157 Q01726
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Top Melanocyte Stimulating Hormone Receptor Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days

MSHR Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Melanocyte Stimulating Hormone Receptor (MSHR) Interaction Partners

Mouse (Murine) Melanocyte Stimulating Hormone Receptor (MSHR) interaction partners

  1. MC1-mediated effects were reduced, and MC3 (show MC3R Proteins) anti-inflammatory circuits predominated. Mice bearing a nonfunctional MC1 displayed a transient exacerbation of neutrophil recruitment after global I/R, which diminished by 2 hours.

  2. A melanin-independent interaction between Mc1r and Met signaling pathways is required for hepatocyte growth factor (show HGF Proteins)-dependent melanoma.

  3. In summary, we have identified a new alpha-MSH-MC1R physiologic pathway that reduces HO-induced RPE (show RPE Proteins) cell damage, and might minimize the risk of developing AMD (show AMD1 Proteins).

  4. Absence of Mc1r does not impair the inflammatory response to UV radiation or the generation of immunosuppression.

  5. MC1R decrease the inflammation in vitro and vivo, and might be part of a signaling pathway in inflammatory diseases.

  6. Melanocortin receptors 1 and 5 might mediate inhibitory effects of alpha-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice.

  7. MC1R regulates melanoma cell migration via inhibition of syndecan-2 (show SDC2 Proteins) expression.

  8. Spatiotemporal localization of MC1R and alpha-MSH in cutaneous wounds warrants future investigation into the role of MC1R/alpha-MSH signaling in the inflammatory and fibroproliferative responses to cutaneous injury.

  9. Data show RNA interference that targets Ube3a (show ube3a Proteins) in P19 (show CDKN2D Proteins) cells caused downregulation of Mc1r and Nr4a2 (show NR4A2 Proteins), whereas overexpression of Ube3a (show ube3a Proteins) results in the upregulation of Mc1r and Nr4a2 (show NR4A2 Proteins).

  10. MC1R contributes to pain of inflammatory origin.

Human Melanocyte Stimulating Hormone Receptor (MSHR) interaction partners

  1. MC1R status is associated with BRAF (show BRAF Proteins)(V600E), BRAF (show BRAF Proteins)(V600K), and NRAS (show NRAS Proteins) mutations in cutaneous melanomas

  2. Study found that HBD2 (show DEFB4 Proteins) bound tightly to Mc1r with an affinity similar to that of HBD3 (show DEFB103A Proteins)

  3. Six MC1R mutations segregated with the phenotype in seven families, including a p.Val174del in-frame deletion and a p.Tyr298* nonsense mutation, that were analyzed for function in heterologous HEK293 cells.

  4. Even after taking into account potential confounding effects of MC1R genotype and various lifestyle factors that close relatives may share, family history of skin cancer remained strongly associated with early-onset basal cell carcinoma

  5. Woman who carried a deleterious CDKN2A mutation and was also homozygous for the MC1R variant allele R160W developed 20 cutaneous melanomas in her lifetime.

  6. The pattern of sequence diversity here does not support a model of strong selective constraint on MC1R in Northern Island Melanesia.

  7. Functional characterization of MC1R-TUBB3 intergenic splice variants of the human melanocortin 1 receptor has been undertaken in response to ultraviolet irradiation.

  8. none of the three variants of the MC1R gene and related haplotypes be associated with sporadic form of Parkinson disease in Chinese Han population from Mainland China.

  9. MC1R genotype is a risk factor for the development of BCC in Greek patients independently of pigmentary characteristics, and the combination of MC1R variants may modulate this risk.

  10. Interestingly, we observed an increased risk of melanoma in subjects with darker skin and lower nevus count, usually considered at low risk, when carrying melanocortin 1 receptor polymorphisms.

Cow (Bovine) Melanocyte Stimulating Hormone Receptor (MSHR) interaction partners

  1. The e and E+ are the main MC1R haplotypes in taurine or intermediate breeds from China. The haplotypes defined by c.416C>T, c.583C>T and c.890T>C, found mostly in China and Bangladesh, are the typical haplotypes of Bos indicus.

  2. Recombinants in a 5 Mb region surrounding the cluster of tyrosine kinase receptor genes implicated PDGFRA as the strongest positional candidate gene interacting with MC1R and modifying black coat color in an F Nellore-Angus population.

  3. Six solid colors occur in Highland cattle: black, dun, silver dun and red, yellow, and white. These six coat colors are explained by a non-epistatic interaction of the genotypes at the MC1R and PMEL (show PMEL Proteins) genes.

  4. the relationship of polymorphism of the MC1R with coat colour

  5. In China Holstein Black-white Cattle, China Holstein Red-white Cattle, Luxi Yellow Cattle and Bohai Black Cattle, three alleles (ED, E+ and e) in MC1R were identified and important SNP at 725 position of the MC1R coding region was found.

  6. Sequence analysis revealed variation in the TYRP1 (exon 5) and MC1R genes; restriction enzyme analysis of these two genes could distinguish between different colours of Hanwoo cattle.

Horse (Equine) Melanocyte Stimulating Hormone Receptor (MSHR) interaction partners

  1. no significant relationship with behavior at the MC1R locus

Pig (Porcine) Melanocyte Stimulating Hormone Receptor (MSHR) interaction partners

  1. The MC1R gene, located on porcine chromosome 6, is responsible for the Extension coat color locus in Sus scrofa.

  2. Melanocortin receptor 1 gene was not the principal factor affecting the coat color differences of Chinese native pig breeds, but could be used to trace the molecular evolution of pig breeds

  3. Mutational analysis of the MC1R loci in relation to coat color.

  4. Variations in the MC1R gene are associated with coat color.

  5. The Chinese Rongchang pig has the dominant black E(D1) allele at the melanocortin 1 receptor (MC1R) locus.

Melanocyte Stimulating Hormone Receptor (MSHR) Protein Profile

Protein Summary

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Gene names and symbols associated with MSHR

  • melanocortin 1 receptor (Mc1r)
  • melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (MC1R)
  • CMM5 protein
  • e protein
  • MC1-R protein
  • MC1R protein
  • MC5R protein
  • MSH-R protein
  • MSHR protein
  • Mshra protein
  • SHEP2 protein
  • Tob protein

Protein level used designations for MSHR

MC1-R , MSH-R , extension recessive yellow , melanocortin receptor 1 , melanocortin-1 receptor , melanocyte-stimulating hormone receptor , tobacco darkening , melanotropin receptor , BDF3 , alpha melanocyte stimulating hormone receptor , melanocortin 1-receptor , melanocyte stimulating hormone receptor , MC5-R , melanocortin 1 receptor Mc1r , melanocortin receptor 5 , melanocortin 1 receptor , Melanotropin receptor , Melanocortin receptor 1 , Melanocyte-stimulating hormone receptor

17199 Mus musculus
4157 Homo sapiens
281298 Bos taurus
493917 Felis catus
427562 Gallus gallus
489652 Canis lupus familiaris
100750239 Capra hircus
100136907 Equus caballus
494018 Sus scrofa
780501 Ovis aries
493980 Pan troglodytes
100303419 Papio anubis
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