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anti-Methyl-CpG Binding Domain Protein 2 (MBD2) Antibodies

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MBD2 8932 Q9UBB5
MBD2 17191 Q9Z2E1
MBD2 680172  
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Top anti-MBD2 Antibodies at antibodies-online.com

Showing 10 out of 120 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-MBD2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: 721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Goat Un-conjugated EIA, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-MBD2 Antibody Titration: 0.625ug/mlELISA Titer: 1:1562500Positive Control: HepG2 cell lysate WB Suggested Anti-MBD2  Antibody Titration: 0.625 µg/mL ELISA Titer: 1:1562500  Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN334432 (0.3µg/ml) staining of Jurkat cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated WB The anti-MBD2 N-term Antibody (ABIN387915) is used in Western blot to detect MBD2 in A375 cell lysate (lane 1) and mouse brain tissue lysate (lane 2) lysate. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, WB MBD2 Antibody (Center) (ABIN1881531) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the MBD2 antibody detected the MBD2 protein (arrow). MBD2 Antibody (Center) (ABIN1881531) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the MBD2 antibody detected the MBD2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Dog Goat Un-conjugated EIA, IHC (p) Human Adrenal (formalin-fixed, paraffin-embedded) stained with MBD2followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Colon (formalin-fixed, paraffin-embedded) stained with MBD2followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: A431 , B: JurKat C: Raji 10% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details

MBD2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-MBD2 Antibodies

  1. Human Polyclonal MBD2 Primary Antibody for EIA, WB - ABIN356599 : Zhu, Spitz, Zhang, Grossman, Frazier, Wu: Methyl-CpG-binding domain 2: a protective role in bladder carcinoma. in Cancer 2004 (PubMed)
    Show all 5 references for ABIN356599

  2. Human Polyclonal MBD2 Primary Antibody for IF, WB - ABIN1881531 : Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: A Large-scale genetic association study of esophageal adenocarcinoma risk. in Carcinogenesis 2010 (PubMed)
    Show all 3 references for ABIN1881531

  3. Human Polyclonal MBD2 Primary Antibody for WB - ABIN387915 : Ghoshal, Majumder, Datta, Motiwala, Bai, Sharma, Frankel, Jacob: Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression. in The Journal of biological chemistry 2004 (PubMed)
    Show all 2 references for ABIN387915

  4. Human Polyclonal MBD2 Primary Antibody for WB - ABIN2779675 : Xing, Stewart, Gu, Lu, Spitz, Wu: Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer. in British journal of cancer 2008 (PubMed)
    Show all 2 references for ABIN2779675

  5. Human Polyclonal MBD2 Primary Antibody for IHC, ELISA - ABIN334432 : Auriol, Billard, Magdinier, Dante: Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus. in Nucleic acids research 2005 (PubMed)
    Show all 2 references for ABIN334432

  6. Chicken Polyclonal MBD2 Primary Antibody for WB - ABIN2778640 : Le Guezennec, Vermeulen, Brinkman, Hoeijmakers, Cohen, Lasonder, Stunnenberg: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. in Molecular and cellular biology 2006 (PubMed)

  7. Dog (Canine) Polyclonal MBD2 Primary Antibody for EIA, IHC (p) - ABIN375214 : Spruijt, Bartels, Brinkman, Tjeertes, Poser, Stunnenberg, Vermeulen: CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex. in Molecular bioSystems 2010 (PubMed)

More Antibodies against MBD2 Interaction Partners

Human Methyl-CpG Binding Domain Protein 2 (MBD2) interaction partners

  1. downregulation of miR (show MLXIP Antibodies)-221 inhibits cell migration and invasion at least partially through targeting MBD2 (show DPEP2 Antibodies) in the human OSCC cell line UM1.

  2. Specifically, methyl-CpG-binding domain protein 2 (MBD2) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD (show DPEP1 Antibodies) domain and MBD2 (show DPEP2 Antibodies) C-terminus.

  3. MBD2 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.

  4. The dynamics of MBD2 (show DPEP2 Antibodies) deposition across methylated DNA regions was associated with the oncogenic transformation of human mammary cells.

  5. Data suggest that MBD2 (show DPEP2 Antibodies) binds primarily at highly methylated regions, with a strong preference for CpG islands and highlights that MBD2 (show DPEP2 Antibodies) binding sites display increased methylation in primary breast cancer tissues as compared to normal mammary cells.

  6. Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 (show DPEP2 Antibodies) for methylated DNA.

  7. This study investigates the genetic association between methyl-CpG-binding domain (MBD (show DPEP1 Antibodies)) gene polymorphisms and schizophrenia.

  8. The methylated-DNA binding protein (show UBE2V1 Antibodies) MBD2 (show DPEP2 Antibodies) enhances NGFI-A (egr-1 (show EGR1 Antibodies))-mediated transcriptional activation of the glucocorticoid receptor (show NR3C1 Antibodies).

  9. These data point to a potential new approach in targeting the DNA methylation (show HELLS Antibodies) machinery by combination of MBD2 (show DPEP2 Antibodies) and DNMT (show DNMT1 Antibodies) inhibitors.

  10. MBD2 (show DPEP2 Antibodies) seems to play a selective role in gene repression depending on the CpG content of the promoter region

Mouse (Murine) Methyl-CpG Binding Domain Protein 2 (MBD2) interaction partners

  1. Mbd2 has a key role regulating expression of a range of genes that are associated with optimal dendritic cell activation and function.

  2. MBD2 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.

  3. methyl-CpG-binding domain protein 2 (MBD2), an epigenetic regulator, controls autoimmunity and EAE through T-bet/Hlx (show HLX Antibodies).

  4. Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 for methylated DNA.

  5. miR (show MLXIP Antibodies)-290/371-Mbd2-Myc (show MYC Antibodies) circuit regulates glycolytic metabolism to promote pluripotency.

  6. these findings suggest that CpG methylation and MBD2 are involved in altering Scn3a (show SCN3A Antibodies) expression during postnatal development and seizure condition.

  7. Data suggest that methyl-CpG binding domain protein 2 (MBD2) gene knockout may lead to accumulation of more deposits on the Bruch's membrane (BM) and influence the pathogenesis of age-related macular degeneration (AMD (show AMD1 Antibodies)).

  8. In metastatic colorectal cancer cells, reduced levels of miR (show MLXIP Antibodies)-221* and miR (show MLXIP Antibodies)-224 increase levels of MBD2, thereby decreasing expression of the metastasis suppressor maspin (show SERPINB5 Antibodies).

  9. Mbd2 has a key role in promoting the Treg-specific demethylation region demethylation, Foxp3 (show FOXP3 Antibodies) expression, and Treg-suppressive function.

  10. Our results strengthen the possibility that MeCP2 (show MECP2 Antibodies) and MBD2 direct interactions could crosslink chromatin fibers and therefore give novel insight into the molecular mechanism of MBD (show DPEP1 Antibodies) mediated global heterochromatin architecture.

MBD2 Antigen Profile

Protein Summary

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MBD2

  • methyl-CpG binding domain protein 2 (MBD2) antibody
  • methyl-CpG binding domain protein 2 (LOC100345590) antibody
  • methyl-CpG binding domain protein 2 (Mbd2) antibody
  • methyl-CpG binding domain protein 2 (mbd2) antibody
  • DMTase antibody
  • MBD2 antibody
  • MBD2a antibody
  • NY-CO-41 antibody
  • wu:fa97f06 antibody
  • zgc:111862 antibody

Protein level used designations for MBD2

methyl-CpG binding domain protein 2 , demethylase , methyl-CpG-binding domain protein 2 , methyl-CpG-binding protein MBD2 , methyl-CpG binding protein MBD2

GENE ID SPECIES
455427 Pan troglodytes
100345590 Oryctolagus cuniculus
693801 Macaca mulatta
8932 Homo sapiens
17191 Mus musculus
337105 Danio rerio
399118 Xenopus laevis
497269 Gallus gallus
483975 Canis lupus familiaris
100337206 Bos taurus
680172 Rattus norvegicus
Selected quality suppliers for anti-MBD2 (MBD2) Antibodies
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