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Mucolipin 1 Proteins (MCOLN1)

MCOLN1 encodes a memberof the transient receptor potential (TRP) cation channel gene family. Additionally we are shipping MCOLN1 Antibodies (35) and MCOLN1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MCOLN1 57192 Q9GZU1
MCOLN1 94178 Q99J21
Rat MCOLN1 MCOLN1 288371  
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Top MCOLN1 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

MCOLN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Mucolipin 1 (MCOLN1) Interaction Partners

Zebrafish Mucolipin 1 (MCOLN1) interaction partners

  1. study characterized mcoln1.1 and mcoln1.2, the putative co-orthologs of human MCOLN1 gene

Human Mucolipin 1 (MCOLN1) interaction partners

  1. This review summarizes the current understanding of TRPML1 activation and regulation

  2. target of rapamycin (TOR), a nutrient-sensitive protein kinase that negatively regulates autophagy, directly targets and inactivates the TRPML1 channel and thereby functional autophagy, through phosphorylation

  3. lysosomal adaptation to environmental cues such as nutrient levels requires mTOR (show FRAP1 Proteins)/TFEB (show TFEB Proteins)-dependent, lysosome-to-nucleus regulation of lysosomal ML1 channels and Ca(2 (show CA2 Proteins)+) signaling.

  4. TRPML1 has a novel role in protecting against lysosomotropic amine toxicity.

  5. Retinal pigmented epithelial cells develop a punctate phenotype within 48 hours of small interfering (si)RNA-induced TRPML1-knockdown.

  6. Data identified proteins as candidate TRPML1 interactors, and some false-positive interactors.

  7. TRPML1 works in concert with ZnT4 (show SLC30A4 Proteins) to regulate zinc translocation between the cytoplasm and lysosomes.

  8. findings show that TRPML1-mediated lysosomal Ca(2 (show CA2 Proteins) ) release is dramatically reduced in Niemann-Pick disease cells; propose that abnormal accumulation of luminal lipids causes secondary lysosome storage by blocking TRPML1- and Ca(2 (show CA2 Proteins) )-dependent lysosomal trafficking

  9. PI(4,5)P(2) may serve as a negative cofactor for intracellular channels such as TRPML1

  10. an acute siRNA-mediated loss of TRPML1 specifically causes a leak of lysosomal protease cathepsin B (show CTSB Proteins) (CatB) into the cytoplasm. CatB leak is associated with apoptosis, which can be prevented by CatB inhibition.

Cow (Bovine) Mucolipin 1 (MCOLN1) interaction partners

  1. an NAADP-sensitive Ca(2 (show CA2 Proteins)+) release channel is characteristic of TRP-ML1 channels

Mouse (Murine) Mucolipin 1 (MCOLN1) interaction partners

  1. Silencing of TRPML1 hindered phagosome fusion with lysosomes.

  2. These results demonstrate that the PtdIns(3,5)P2-Mcoln1 axis has an important role in ssRNA transportation into lysosomes in DCs.

  3. ML1-null mice develop a primary, early-onset muscular dystrophy independent of neural degeneration. Dystrophin-glycoprotein complex and known membrane repair proteins are expressed normally, but membrane resealing was defective in ML1-null muscle fibers.

  4. Data identified proteins as candidate TRPML1 interactors, and some false-positive interactors.

  5. Transfection of CAMs with plasmids containing a full-length TRP-ML1 gene enhanced FasL (show FASL Proteins)-induced two-phase Ca2 (show CA2 Proteins)+ release.

  6. Loss of Trpml1 causes reduced levels and mislocalization of the gastric proton pump and alters the secretory canaliculi, causing hypochlorhydria and hypergastrinemia.

  7. This study describes, for the first time, a defect in macroautophagy in mucolipin-1-deficient mouse neurons.

  8. the loss of TRPML1 function results in intracellular chelatable zinc dyshomeostasis.

  9. TRPML1 is expressed in the mouse inner ear.

  10. there is a hierarchy controlling the subcellular distributions of the TRPMLs such that TRPML1 and TRPML2 dictate the localization of TRPML3 and not vice versa

MCOLN1 Protein Profile

Protein Summary

This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV.

Gene names and symbols associated with Mucolipin 1 Proteins (MCOLN1)

  • mucolipin 1a (mcoln1a)
  • mucolipin 1 (MCOLN1)
  • mucolipin 1 (mcoln1)
  • mucolipin 1 (LOAG_04987)
  • mucolipin 1 (Mcoln1)
  • 2210015I05Rik protein
  • MCOLN1 protein
  • mcoln1.1 protein
  • MG-2 protein
  • ML4 protein
  • MLIV protein
  • mln1 protein
  • MST080 protein
  • mucolipidin protein
  • mucolipin-1 protein
  • TRP-ML1 protein
  • TRPM-L1 protein
  • TRPML1 protein
  • zgc:63619 protein

Protein level used designations for Mucolipin 1 Proteins (MCOLN1)

mucolipin 1 , mucolipin 1.1 , mucolipidin , mucolipidosis type IV protein , mucolipin-1

406689 Danio rerio
426164 Gallus gallus
444113 Xenopus laevis
455656 Pan troglodytes
496811 Xenopus (Silurana) tropicalis
9942391 Loa loa
100601142 Nomascus leucogenys
57192 Homo sapiens
611517 Canis lupus familiaris
505738 Bos taurus
94178 Mus musculus
288371 Rattus norvegicus
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