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MCOLN1 encodes a memberof the transient receptor potential (TRP) cation channel gene family. Additionally we are shipping MCOLN1 Antibodies (47) and MCOLN1 Kits (2) and many more products for this protein.
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study characterized mcoln1.1 and mcoln1.2, the putative co-orthologs of human MCOLN1 gene
This review summarizes the current understanding of TRPML1 activation and regulation
target of rapamycin (TOR), a nutrient-sensitive protein kinase that negatively regulates autophagy, directly targets and inactivates the TRPML1 channel and thereby functional autophagy, through phosphorylation
lysosomal adaptation to environmental cues such as nutrient levels requires mTOR (show FRAP1 Proteins)/TFEB (show TFEB Proteins)-dependent, lysosome-to-nucleus regulation of lysosomal ML1 channels and Ca(2 (show CA2 Proteins)+) signaling.
TRPML1 has a novel role in protecting against lysosomotropic amine toxicity.
Retinal pigmented epithelial cells develop a punctate phenotype within 48 hours of small interfering (si)RNA-induced TRPML1-knockdown.
Data identified proteins as candidate TRPML1 interactors, and some false-positive interactors.
TRPML1 works in concert with ZnT4 (show SLC30A4 Proteins) to regulate zinc translocation between the cytoplasm and lysosomes.
findings show that TRPML1-mediated lysosomal Ca(2 (show CA2 Proteins) ) release is dramatically reduced in Niemann-Pick disease cells; propose that abnormal accumulation of luminal lipids causes secondary lysosome storage by blocking TRPML1- and Ca(2 (show CA2 Proteins) )-dependent lysosomal trafficking
PI(4,5)P(2) may serve as a negative cofactor for intracellular channels such as TRPML1
an acute siRNA-mediated loss of TRPML1 specifically causes a leak of lysosomal protease cathepsin B (show CTSB Proteins) (CatB) into the cytoplasm. CatB leak is associated with apoptosis, which can be prevented by CatB inhibition.
an NAADP-sensitive Ca(2 (show CA2 Proteins)+) release channel is characteristic of TRP-ML1 channels
Silencing of TRPML1 hindered phagosome fusion with lysosomes.
These results demonstrate that the PtdIns(3,5)P2-Mcoln1 axis has an important role in ssRNA transportation into lysosomes in DCs.
ML1-null mice develop a primary, early-onset muscular dystrophy independent of neural degeneration. Dystrophin-glycoprotein complex and known membrane repair proteins are expressed normally, but membrane resealing was defective in ML1-null muscle fibers.
Transfection of CAMs with plasmids containing a full-length TRP-ML1 gene enhanced FasL (show FASL Proteins)-induced two-phase Ca2 (show CA2 Proteins)+ release.
Loss of Trpml1 causes reduced levels and mislocalization of the gastric proton pump and alters the secretory canaliculi, causing hypochlorhydria and hypergastrinemia.
This study describes, for the first time, a defect in macroautophagy in mucolipin-1-deficient mouse neurons.
the loss of TRPML1 function results in intracellular chelatable zinc dyshomeostasis.
TRPML1 is expressed in the mouse inner ear.
there is a hierarchy controlling the subcellular distributions of the TRPMLs such that TRPML1 and TRPML2 dictate the localization of TRPML3 and not vice versa
This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV.
, mucolipin 1.1
, mucolipidosis type IV protein