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anti-Multiple Endocrine Neoplasia I (MEN1) Antibodies

MEN1 encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Additionally we are shipping MEN1 Proteins (2) and MEN1 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MEN1 17283 O88559
MEN1 4221 O00255
MEN1 29417 Q9WVR8
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Top anti-MEN1 Antibodies at antibodies-online.com

Showing 10 out of 106 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ChIP, ICC, IF, IHC, IHC (p), IP, WB Detection of Human Menin by Western Blot and Immunoprecipitation.  Samples:  Whole cell lysate (30 or 60 mcg for WB, 1 confluent 10 cm plate for IP) from 293T cells.  Antibody: Affinity purified rabbit anti-Menin ABIN151584 used 0.5 mcg/ml for Western Blot and as indicated for IP.  Detection: Chemiiluminescence. 100 μL Log in to see 5 to 7 Days
$486.94
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western Blot (WB) analysis of specific cells using Menin Polyclonal Antibody. 100 μL Log in to see 14 Days
$175.80
Details
Human Rabbit Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 6 Days
$275.00
Details
Human Goat Un-conjugated IP, PLA, WB Proximity Ligation Assay: Menin Antibody [ABIN151753] - Secondary-conjugate Duolink II PLA in Hela cells. goat anti-human MEN1 (ABIN151753) and rabbit anti-human NFKappaB2 (ABIN1517539). Image merged from DAPI (2ms) and Texas Red (200ms) exposures, 40X magnification. Proximity Ligation Assay: Menin Antibody [ABIN151753] - Secondary-conjugate Duolink II PLA in Hela cells. goat anti-human MEN1(ABIN151753). and rabbit anti-human p53 (ABIN151753). Image merged from DAPI (2ms) and Texas Red (100ms) exposures, 40X magnification. 100 μL Log in to see 5 to 7 Days
$486.94
Details
Chicken Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of Menin staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Menin expression in K562 (A), Jurkat (B), A431 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Goat Biotin IP, WB Western Blot: Menin Antibody [Biotin] [NBP1-71794] - Whole cell lysate from HEK 293T (50, 15, and 5 ug). Antibody used at 1.0 ug/ml. Detection: Streptavidin-HRP and chemiluminescence with an exposure time of 30 seconds. 0.1 mg Log in to see 6 to 9 Days
$500.06
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000;  TMB staining;  Read the data in MicroplateReader by 450 Formalin-fixed and paraffin embedded mouse lung labeled with Rabbit Anti Menin/Men1 Polyclonal Antibody, Unconjugated (ABIN676343) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Mouse Un-conjugated CyTOF, ELISA, FACS, IHC, WB Immunohistochemistry: Menin Antibody (7D3E10) [NBP2-37251] - Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using MEN1 mouse mAb with DAB staining. Western Blot: Menin Antibody (7D3E10) [NBP2-37251] - Western blot analysis using MEN1 mAb against HEK293 (1) and MEN1 (AA: 392-554)-hIgGFc transfected HEK293 (2) cell lysate. 0.1 mL Log in to see 5 to 7 Days
$447.56
Details
Human Rabbit Un-conjugated IP, WB Western Blot: Menin Antibody [NBP2-17277] - Sample (30 ug of whole cell lysate) A: Raji 7. 5% SDS PAGE gel, diluted at 1:500. 0.1 mL Log in to see 6 to 9 Days
$447.56
Details

MEN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-MEN1 Antibodies

  1. Human Polyclonal MEN1 Primary Antibody for ChIP, ICC - ABIN151584 : Hughes, Rozenblatt-Rosen, Milne, Copeland, Levine, Lee, Hayes, Shanmugam, Bhattacharjee, Biondi, Kay, Hayward, Hess, Meyerson: Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. in Molecular cell 2004 (PubMed)
    Show all 26 references for ABIN151584

More Antibodies against MEN1 Interaction Partners

Mouse (Murine) Multiple Endocrine Neoplasia I (MEN1) interaction partners

  1. Data show that progranulin (show GRN Antibodies) is upregulated in neuroendocrine tumors (NETs) and islets of the multiple endocrine neoplasia 1 protein (MEN1) mouse as well as in the serum of patients with pancreatic NETs associated with glucagonoma syndrome.

  2. Although mice lacking Men1 developed insulinomas as expected, elimination of ARC (show NOL3 Antibodies) in this context did not significantly alter tumor load. Cellular rates of proliferation and death in these tumors were also not perturbed in the absence of ARC (show NOL3 Antibodies).

  3. The study characterized the binding position of Ezh2 (show EZH2 Antibodies) and menin at all annotated genes in embryonic stem cells and B and T lymphocytes.

  4. Data demonstrate that loss of Men1 in pancreatic islet cells alters the epigenetic landscape of its target genes during early stages of pancreatic neuroendocrine tumor formation.

  5. Data show that menin, encoded by the MEN1 gene, inhibits the transcriptional activity of nuclear receptor liver X receptor alpha (LXRalpha (show NR1H3 Antibodies)).

  6. Conditional knockout of beta-catenin (show CTNNB1 Antibodies) suppresses the tumorigenesis and growth of Men1-deficient pancreatic neuroendocrine tumors.

  7. miR (show MLXIP Antibodies)-802 expression levels are increased in lung carcinoma tissues and targets the tumor suppressor menin and downregulates its expression.

  8. CDK4 (show CDK4 Antibodies) is a critical downstream target of MEN1-dependent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 (show CDK2 Antibodies) is dispensable for tumorigenesis in these neuroendocrine cell types.

  9. This work shows that Men1 ablation in the pancreatic beta-cells leads to the inactivation of specific transcription factors, resulting in glucagon (show GCG Antibodies)-expressing tumor development, which sheds light on the mechanisms of islet tumorigenesis.

  10. Menin regulates spinal glutamate (show GRIN1 Antibodies)-GABA balance through GAD65 (show GAD2 Antibodies) contributing to neuropathic pain.

Human Multiple Endocrine Neoplasia I (MEN1) interaction partners

  1. rs2959656, a nonsynonymous variant in MEN1, is associated with the development of clinically active pituitary adenoma.

  2. Study acts as a further supplement of the genetic features of neuroendocrine tumors. Somatic mutations of three potential tumor-related genes (HRAS (show HRAS Antibodies), PAK1 (show PAK1 Antibodies) and MEN1) might contribute to the tumorigenesis of thymic neuroendocrine tumors with EAS.

  3. The results and clinical course of disease in this case indicate the potential role of menin in the development of non-endocrine or atypical-endocrine tumors in MEN1 patients.

  4. cellular staining for menin also reveals the distribution of menin in the cell membrane and the punctate-like cell organelles

  5. study to evaluate frequency of Multiple Endocrine Neoplasia type 1 (MEN1) in patients with pituitary adenoma and to perform genetic analysis and familial screening of those with MEN1; genetic analysis showed MEN1 mutations in 4 index cases: IVS4+1 G>A, IVS3-6 C>T, c.1547insC and a new D180A mutation

  6. Study reports the coexistence of a germline intronic heterozygote variation at the MEN1 gene (IVS4+1G>T) and a germline mutation of exon 11 of RET proto-oncogene (show RET Antibodies) (K666M) in a large Italian family and describes clinical manifestations in the carriers.

  7. novel MEN1 c.8251G>A mutation in a family with multiple endocrine neoplasia type 1

  8. progenitors. Our findings define SON as a fine-tuner of the MLL (show MLL Antibodies)-menin interaction and reveal short SON overexpression as a marker indicating aberrant transcriptional initiation in leukemia.

  9. interaction between menin and Dnmt1 (show DNMT1 Antibodies) reversibly regulates pancreatic cancer cell growth downstream of Hedgehog (show SHH Antibodies) pathways with complex mutual modulation networks.

  10. Molecular analysis of sporadic insulinoma (show RPS15 Antibodies) revealed presence of three novel exonic mutations, two novel intronic variations, three reported exon SNPs, and one intronic SNP (rs669976).

MEN1 Antigen Profile

Protein Summary

This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with MEN1

  • multiple endocrine neoplasia I (men1) antibody
  • multiple endocrine neoplasia I (MEN1) antibody
  • multiple endocrine neoplasia 1 (Men1) antibody
  • multiple endocrine neoplasia I (Men1) antibody
  • AW045611 antibody
  • MEAI antibody
  • menin antibody
  • SCG2 antibody

Protein level used designations for MEN1

multiple endocrine neoplasia 1 , menin , multiple endocrine neoplasia I , menin-like , multiple endocrine neoplasia protein

GENE ID SPECIES
549115 Xenopus (Silurana) tropicalis
692344 Felis catus
743979 Pan troglodytes
100158320 Xenopus laevis
100411101 Callithrix jacchus
100441476 Pongo abelii
100472417 Ailuropoda melanoleuca
100538227 Danio rerio
17283 Mus musculus
4221 Homo sapiens
29417 Rattus norvegicus
483758 Canis lupus familiaris
100523533 Sus scrofa
539431 Bos taurus
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