Menin antibody (C-Term)

Catalog No. ABIN6972340

Product Details anti-Menin Antibody

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Menin antibody is un-conjugated

Application: Western Blotting (WB), ChIP DNA-Sequencing (ChIP-seq), Chromatin Immunoprecipitation (ChIP)

Characteristics: Menin (MEN1, SCG2) is a tumor suppressor and a component of multiple MLL-containing protein complexes (MLL, ACSOM, MLL2/3 and MLL3/4), which methylate histone H3 at lysine 4. Menin interacts directly with MLL through a domain in the N-terminus of MLL. It also interacts with RNA polymerase II large subunit C-terminal domain phosphorylated at Ser5. Menin is involved in the activation of HOX gene expression and is localized along with MLL at several HOX gene promoters. It is also important for activating the expression of several cell cycle regulators, indicating a mechanism for its role as a tumor suppressor. Defects in Menin are associated with inherited Multiple Endocrine Neoplasia type I, a dominant predisposition to cancer of a number of endocrine tissues. Menin antibody (pAb) was raised in a Rabbit host. It has been validated for use in Chromatin Immunoprecipitation, ChIP-Seq and Western blot, it has been shown to react with Human and Mouse samples.

Purification: Affinity Purified

Immunogen: This Menin antibody was raised against a peptide corresponding to amino acids within the C-terminal region of human Menin.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Target Details for Menin

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Alternative Name: Menin (MEN1 Products)

Synonyms: MEAI antibody, SCG2 antibody, menin antibody, meai antibody, scg2 antibody, AW045611 antibody, menin 1 antibody, menin 1 L homeolog antibody, multiple endocrine neoplasia I antibody, multiple endocrine neoplasia 1 antibody, MEN1 antibody, men1 antibody, men1.L antibody, Men1 antibody

Molecular Weight: 80 kDa

NCBI Accession: NP_570716

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity