Menin antibody (AA 1-615)

Catalog No. ABIN7159407

Product Details anti-Menin Antibody

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Binding Specificity: AA 1-615

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Menin antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Menin protein (1-615AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Menin

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Alternative Name: MEN1 (MEN1 Products)

Synonyms: MEAI antibody, SCG2 antibody, menin antibody, meai antibody, scg2 antibody, AW045611 antibody, menin 1 antibody, menin 1 L homeolog antibody, multiple endocrine neoplasia I antibody, multiple endocrine neoplasia 1 antibody, MEN1 antibody, men1 antibody, men1.L antibody, Men1 antibody

Background:

Background: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates \\\'Lys-4\\\' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.

Aliases: MEA 1 antibody, MEA1 antibody, MEN 1 antibody, Men1 antibody, MEN1_HUMAN antibody, Menin antibody, Multiple Endocrine Adenomatosis 1 antibody, Multiple Endocrine Neoplasia 1 antibody, SCG 2 antibody, SCG2 antibody, Suppressor Candidate Gene 2 antibody, Wermer syndrome antibody, ZES antibody, Zollinger Ellison Syndrome antibody

UniProt: O00255

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity