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NPPB is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. Additionally we are shipping Natriuretic Peptides B Antibodies (171) and Natriuretic Peptides B Kits (28) and many more products for this protein.
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Human NPPB Protein expressed in Escherichia coli (E. coli) - ABIN666711
Harada, Fujita, Miyamoto, Kimura, Maruyama, Furia, Miyata, Taniguchi: Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. in Cell 1989
Show all 2 references for ABIN666711
Human NPPB Protein expressed in Wheat germ - ABIN1312892
Shaw, Fildes, Pucha?ka, Basith, Yonan, Williams: BNP directly immunoregulates the innate immune system of cardiac transplant recipients in vitro. in Transplant immunology 2008
CNP and BNP serve as oocyte maturation inhibitor to inhibit oocyte maturation in mammals
ANP and BNP gene expression differs considerably between cardiac chambers in the first 72 hours of life in healthy piglets, resembling the transition from fetal to neonate circulation. The cardiac gene expression does not explain plasma concentrations.
Up-regulation of BNP and a reduction in a ratio of sarcoplasmic reticulum calcium ATPase 2a in failing myocardium are observed in a porcine model of tachycardia.
Data show that all five molecules, BNP, ICAM-1 (show ICAM1 Proteins), TNF-alpha (show TNF Proteins), VCAM-1 (show VCAM1 Proteins) and IL-6 (show IL6 Proteins), quickly and reliably signaled adverse interactions.
identification and characterization of a novel alternatively spliced variant of porcine and human NPPB (show BNP Proteins) resulting from exon 2 skipping
Arial natriuretic factor (ANF (show HESX1 Proteins)) and N-terminal proANF may be better suited than brain natriuretic peptide (show BNP Proteins) as markers of cardiac preload during the development and treatment of acute heart failure.
Regional differences in BNP and CNP (show NPPC Proteins) expression were observed in myocardium with sustained left ventricular dyssynchronous contraction.
The BNP level may be of value in evaluating severity and prognosis in patients with acute lung injury/acute respiratory distress syndrome.
Data show that both furin (show FURIN Proteins) and brain type natriuretic peptide (BNP) were more sensitive than corin (show CORIN Proteins) in predicting cardiovascular complications in type 2 diabetes mellitus (T2DM) patients.
BNP test is a good point-of-care for the management of heart failure despite a relatively poor precision.
B-type natriuretic peptide (show BNP Proteins) levels pre left ventricular assist device implantation may predict ventricular arrhythmia post LVAD implantation.
Data suggest testing for aminoterminal pro-B-type natriuretic peptide (show BNP Proteins) (NT-proBNP) should be performed in the hospitalized very elderly, because of the very high prevalence of underlying heart failure (HF) and its impact on in-hospital mortality.
Data suggest that low serum levels of NT-proBNP are an independent risk factor/biomarker for diagnosis of NAFLD; low serum levels of NT-proBNP correlate with presence of elevated fat accumulation in liver (in a multi-ethnic, cross-sectional study).
Data suggest that risk of diabetes type 2 increases in subjects with asymptomatic atherosclerosis as plasma NT-proBNP levels increase, probably in response to pathophysiological conditions leading to high levels of NT-proBNP (and interleukin 6 (show IL6 Proteins)).
high expression levels of BNP promote the apoptosis of myocardial cells through the lncRNA LSINCT5 mediator.
Obstructive CAD causing myocardial ischemia is associated with increased levels of NT-proBNP.
Patients with myocardial ischemia had significantly higher BNP levels at all times, compared to patients without ischemia. Myocardial ischemia did not lead to a differential delayed release of BNP.
mouse trigeminal neurons endogenous BNP acts on NPR-A (show NPR1 Proteins) receptors to determine constitutive depression of P2X3 (show P2RX3 Proteins) receptor function. Tonic inhibition of P2X3 (show P2RX3 Proteins) receptor activity by BNP/NPR-A (show NPR1 Proteins)/PKG (show PRKG1 Proteins) pathways occurs via two distinct mechanisms: P2X3 (show P2RX3 Proteins) serine phosphorylation and receptor redistribution to non-raft membrane compartments
The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha in obstructive kidney disease, possibly via iNOS-derived nitric oxide and BNP.
Data (including data from studies in knockout mice) suggest expression of ANP (show NPPA Proteins)/BNP/GC-A (show GUCA1A Proteins) (atrial natriuretic peptide (show NPPA Proteins), brain natriuretic peptide (show BNP Proteins), and guanylyl cyclase-A (show NPR1 Proteins)) is important in embryonic neovascularization and organogenesis.
Goalpha plays a role in ANF sorting during intracellular vectorial transport and with the presence of a mechanism that preserves the molar relationship between cellular ANF and BNP.
The RNA-Seq demonstrates that NPPB (show BNP Proteins) which well activates natriuretic peptide receptor 1 (NPR1 (show NPR1 Proteins)), is well expressed in mouse dorsal root ganglian.
a slow modulatory action by BNP on TRPV1 (show TRPV1 Proteins) and P2X3 (show P2RX3 Proteins) receptors outlining the role of this peptide as a negative regulator of trigeminal sensory neuron excitability to nociceptive stimuli
Natriuretic peptides buffer renin (show REN Proteins)-dependent hypertension.
BNP-NPRA (show NPR1 Proteins) signaling is involved in both itch and pain and does not function upstream of the GRP (show UCMA Proteins)-GRPR (show GRPR Proteins) dedicated neuronal pathway.
Data indicate that the identified stress-responsive enhancer of Nppa (show NPPA Proteins) and Nppb (show BNP Proteins), the most common markers of heart failure, is a 650-bp fragment within 50 kb of the Nppa (show NPPA Proteins) and Nppb (show BNP Proteins) loci.
these results define the primary pruriceptive neurons, characterize Nppb as an itch-selective neuropeptide, and reveal the next two stages of this dedicated neuronal pathway.
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
gamma-brain natriuretic peptide
, natriuretic peptides B
, brain type natriuretic peptide
, natriuretic peptide precursor B
, natriuretic protein
, brain natriuretic peptide
, Brain natriuretic factor
, natriuretic peptide precursor type B
, Gamma-brain natriuretic peptide