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NRP1 encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Additionally we are shipping Neuropilin 1 Proteins (39) and Neuropilin 1 Kits (36) and many more products for this protein.
Showing 10 out of 276 products:
Mouse (Murine) Monoclonal Neuropilin 1 Primary Antibody for FACS - ABIN2660079
Hansen, Hutzler, Abel, Alter, Stockmann, Kliche, Albert, Sparwasser, Sakaguchi, Westendorf, Schadendorf, Buer, Helfrich: Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth. in The Journal of experimental medicine 2012
Show all 6 references for ABIN2660079
Mouse (Murine) Monoclonal Neuropilin 1 Primary Antibody for FACS - ABIN2658180
Milpied, Massot, Renand, Diem, Herbelin, Leite-de-Moraes, Rubio, Hermine: IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression. in Blood 2011
Show all 6 references for ABIN2658180
Human Monoclonal Neuropilin 1 Primary Antibody for IP, ELISA - ABIN1327097
Ohkusu-Tsukada, Ohta, Kawakami, Toda: Adjuvant effects of formalin-inactivated HSV through activation of dendritic cells and inactivation of myeloid-derived suppressor cells in cancer immunotherapy. in International journal of cancer. Journal international du cancer 2010
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Human Polyclonal Neuropilin 1 Primary Antibody for FACS, IHC (p) - ABIN653013
Yoshizuka, Chen, Xu, Liao, Hong, Hu, Yu, Han, Chen, Sun: A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis. in Molecular and cellular biology 2012
Studies suggest that the activation of NRP-1 (show NELL1 Antibodies) by PlGF (show PGF Antibodies) directly contributes to tumour aggressiveness and to melanoma escape from anti-VEGF-A (show VEGFA Antibodies) therapies.
REVIEW: Nrp1 (show NELL1 Antibodies) functions in the vasculature is critical for the development of targeted therapeutics for cancer and vascular diseases such as atherosclerosis and retinopathies.
High Expression of Neuropilin-1 Associates with Hepatocellular Carcinoma.
Increased NRP-1 (show NELL1 Antibodies) expression is associated with metastatic endometrial and lung cancers.
miR (show MLXIP Antibodies)-152 suppression in NSCLC cells might promote neuropilin-1 mediated cancer metastasis.
NRP-1 (show NELL1 Antibodies) was found to be overexpressed in gastric cancer (GC) tissues, and its expression correlates with the clinical staging, tumor differentiation and pathological types of gastric cancer.
Both placental NRP1 and VEGF were expressed at lower levels in women with pre-eclampsia and homocysteine-treated mice, which may contribute to endothelial damage.
NRP1 (show NELL1 Antibodies) was targeted by miR130a and miR130b at the binding site of chromosome 10: 334668643466870, which was involved in the axon guidance signaling pathway.
Semaphorin-3a (show SEMA3A Antibodies), neuropilin-1 and plexin-A1 (show PLXNA1 Antibodies) are axonal guidance molecules that have been recently implicated in regulating bone metabolism.
neuropilin-1 is regulated in the oral epithelium and is selectively up-regulated during epithelial dysplasia
Sepsis per se markedly promoted the expression of Nrp-1 of CD4 (show CD4 Antibodies)(+)CD25 (show IL2RA Antibodies)(+)Tregs. Foxp-3 (show FOXP3 Antibodies)/CTLA-4 (show CTLA4 Antibodies)/TGF-beta (show TGFB1 Antibodies)(m+) of Nrp-1(high)Tregs were upregulated by septic challenge.
suppression of beta3-integrin (show ITGB3 Antibodies) in mice leads to the activation of a neuropilin-1 (NRP1)-dependent cell migration pathway in endothelial cells via a mechanism that depends on NRP1's mobilisation away from mature focal adhesions following VEGF (show VEGFA Antibodies)-stimulation
The results show that high vs. low expression of Nrp-1 or Helios (show ZNFN1A2 Antibodies) does not unequivocally identify Treg clones of thymic or peripheral origin.
Nrp1 in endothelial cells suppresses TGFbeta (show TGFB1 Antibodies) activation and signaling by forming intercellular protein complexes with beta8 integrin.
In vascular sprouting, neuropilin-1 suppresses the stalk-cell phenotype by limiting Smad2 (show SMAD2 Antibodies)/3 activation through Alk1 (show ACVRL1 Antibodies) and Alk5 (show TGFBR1 Antibodies). Notch (show NOTCH1 Antibodies) downregulates Nrp1, thus relieving the inhibition of Alk1 (show ACVRL1 Antibodies) and Alk5 (show TGFBR1 Antibodies), thereby driving stalk-cell behaviour.
NRP1 enables ECM (show MMRN1 Antibodies)-induced filopodia formation for tip cell function during sprouting angiogenesis.
demonstrate that in mice on the C57Bl/6 background EMX1 (show EMX1 Antibodies) plays an essential role in the midline crossing of an axonal subpopulation of the corpus callosum derived from the anterior cingulate cortex. In the absence of EMX1 (show EMX1 Antibodies), cingulate axons display reduced expression of the axon guidance receptor NRP1 and form aberrant axonal bundles within the rostral corpus callosum.
Study showed that Nrp1 expression paralleled with that of DDR2 (show DDR2 Antibodies) during osteoblast differentiation. Nrp1 assisted the promoting role of DDR2 (show DDR2 Antibodies) in osteoblast differentiation, via activation of DDR2 (show DDR2 Antibodies)-mediated downstream signaling.
These findings indicate a new role for Nrp1 in the maintenance of the visceral SMC (show DYM Antibodies) contractile phenotype required for normal GI motility in aged mice.
Neuropilin-1 and its co-receptor plexinA1 (show PLXNA1 Antibodies) are necessary to bias the extension of the dendrites of retinal ganglion cells to the apical side of the cell, and ectopically expressed class III semaphorins (Sema3s) disrupt this process.
binding of Neuropilin-1 to VEGFR-2 (show KDR Antibodies) requires the PDZ (show INADL Antibodies)-binding domain of neuropilin-1
Neuropilin-1 is essential for enhanced VEGF(165)-mediated vasodilatation in collateral-dependent coronary arterioles of exercise-trained pigs.
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors\; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
, A5 antigen
, transmembrane receptor
, vascular endothelial cell growth factor 165 receptor
, A5 protein
, Neuropilin-1 precursor (A5 protein)