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PRDM1 encodes a protein that acts as a repressor of beta-interferon gene expression. Additionally we are shipping PR Domain Containing 1, with ZNF Domain Proteins (9) and PR Domain Containing 1, with ZNF Domain Kits (3) and many more products for this protein.
Showing 10 out of 189 products:
Human Monoclonal PRDM1 Primary Antibody for ChIP, ELISA - ABIN153174
John, Clements, Russell, Garrett-Sinha: Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1. in The Journal of biological chemistry 2008
Show all 43 references for ABIN153174
Human Monoclonal PRDM1 Primary Antibody for ICC, FACS - ABIN314189
Liu, Leboeuf, Shi, Li, Wang, Shen, Garcia, Shen, Chen, Janin, Chen, Zhao: Rituximab plus CHOP (R-CHOP) overcomes PRDM1-associated resistance to chemotherapy in patients with diffuse large B-cell lymphoma. in Blood 2007
Show all 11 references for ABIN314189
Human Monoclonal PRDM1 Primary Antibody for WB - ABIN314190
Ohinata, Payer, OCarroll, Ancelin, Ono, Sano, Barton, Obukhanych, Nussenzweig, Tarakhovsky, Saitou, Surani: Blimp1 is a critical determinant of the germ cell lineage in mice. in Nature 2005
Show all 11 references for ABIN314190
Human Polyclonal PRDM1 Primary Antibody for EIA, IHC (p) - ABIN499477
Angelin-Duclos, Cattoretti, Lin, Calame: Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo. in Journal of immunology (Baltimore, Md. : 1950) 2000
Show all 3 references for ABIN499477
Human Monoclonal PRDM1 Primary Antibody for ELISA, WB - ABIN1724737
Ancelin, Lange, Hajkova, Schneider, Bannister, Kouzarides, Surani: Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. in Nature cell biology 2006
Show all 3 references for ABIN1724737
Human Polyclonal PRDM1 Primary Antibody for EIA, IF - ABIN499475
Reimold, Iwakoshi, Manis, Vallabhajosyula, Szomolanyi-Tsuda, Gravallese, Friend, Grusby, Alt, Glimcher: Plasma cell differentiation requires the transcription factor XBP-1. in Nature 2001
Show all 3 references for ABIN499475
Human Polyclonal PRDM1 Primary Antibody for EIA, WB - ABIN401478
Morris, Beresford, Mooney, Boss: Kinetics of a gamma interferon response: expression and assembly of CIITA promoter IV and inhibition by methylation. in Molecular and cellular biology 2002
Show all 3 references for ABIN401478
Cow (Bovine) Polyclonal PRDM1 Primary Antibody for IHC, WB - ABIN2792524
Diehl, Schmidlin, Nagasawa, van Haren, Kwakkenbos, Yasuda, Beaumont, Scheeren, Spits: STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation. in Journal of immunology (Baltimore, Md. : 1950) 2008
Cow (Bovine) Polyclonal PRDM1 Primary Antibody for EIA, WB - ABIN487993
Chang, Angelin-Duclos, Calame: BLIMP-1: trigger for differentiation of myeloid lineage. in Nature immunology 2001
Chicken Polyclonal PRDM1 Primary Antibody for WB - ABIN2780353
González-García, Ocaña, Jiménez-Gómez, Campos-Caro, Brieva: Immunization-induced perturbation of human blood plasma cell pool: progressive maturation, IL-6 responsiveness, and high PRDI-BF1/BLIMP1 expression are critical distinctions between antigen-specific and nonspecific plasma cells. in Journal of immunology (Baltimore, Md. : 1950) 2006
BLIMP1 (PRDM1)expression begins throughout the hypoblast at stage 1 and emerges in single primordial germ cell (PGC (show PGC Antibodies)) precursors in the posterior epiblast at stage 2.
Blimp-1 gene is transcribed during prepupal development when the ecdysteroid titer is high, but the expressed mRNA degrades rapidly.
Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo.
These results suggest that the transient transcriptional repressor dBlimp-1 is important for determining developmental timing in the ecdysone-induced pathway.
Expression of the M- and N-cadherins, previously implicated in driving adaxial cell migration, is largely unaffected by loss of Prdm1a function, suggesting that differential cadherin expression is not sufficient for adaxial cell migration
Prdm1a functions as both a transcriptional activator and repressor during neural crest development.
identify sox6 cis (show CISH Antibodies)-regulatory sequences that drive fast-twitch-specific expression in a Prdm1a-dependent manner
prdm1a expression is upregulated in the absence of Notch (show NOTCH1 Antibodies) function, and inhibiting Notch (show NOTCH1 Antibodies) signaling fails to rescue prdm1a mutants
prdm1a Regulates sox10 (show SOX10 Antibodies) and islet1 (show ISL1 Antibodies) in the development of neural crest and Rohon-Beard sensory neurons.
These results indicate an essential role for prdm1a in the development of the zebrafish craniofacial skeleton.
Here we show that the gene u-boot (ubo), a mutation in which disrupts the induction of embryonic slow-twitch fibers, encodes the zebrafish homolog of Blimp-1
The transcriptional regulator Blimp-1 plays a role in the inception of Neural Crest progenitor fate through BMP signalling.
prdm1/blimp1 has roles in embryo patterning and organogenesis
prdm1 functions to promote the cell fate specification of both neural crest cells and sensory neurons
Data show there was a positive correlation between B cell lymphoma 6 (Bcl-6 (show BCL6 Antibodies)) and B lymphocyte-induced maturation protein 1 (Blimp-1) at the level of mRNA.
The PRDM1 expression appeared to play an essential role in Warthin tumour pathogenesis.
Blimp-1 regulates the transcription of CS1 (show CSH1 Antibodies) gene in NK and B cell lines from multiple myeloma and diffuse large B cell lymphoma patients.
Antineoplastic effects of liposomal short interfering RNA treatment targeting BLIMP1/PRDM1 in primary effusion lymphoma.
The interaction between EBV-miR (show MLXIP Antibodies)-BHRF1-2 and PRDM1 may be one of the mechanisms by which EBV-miRBHRF1-2 promotes Epstein-Barr virus lymphomagenesis.
heterozygous deletion of 6q21 and/or PRDM1 was frequently detected in extranodal NK/T cell lymphoma, nasal type and correlated with downregulation of PRDM1.
KLF4 (show KLF4 Antibodies), together with BLIMP1, plays a critical role in mediating lytic Epstein-Barr virus reactivation in epithelial cells.
Our findings suggest a previously unrecognized role of PRDM1 and human parvovirus B19 in the pathogenesis of Hashimoto thyroiditis
Blimp1-deficient effector T cells fail to produce IL-10 (show IL10 Antibodies), and deficiency in Tr-1 (show TNFRSF11B Antibodies) cell function leads to uncontrolled Th17 cell-driven CNS pathology without the need to stabilize the Th17 phenotype with IL-23 (show IL23A Antibodies)
Positional mapping of PRKD1 (show PRKD1 Antibodies), NRP1 (show NELL1 Antibodies) and PRDM1 as novel candidate disease genes in truncus arteriosus
The escape of a fraction of Primordial germ cells from the Prdm1 deletion was sufficient to recover fairly normal germ cell pools, both in male and female adults
There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.
Reduction of HDAC3 (show HDAC3 Antibodies) or NCoR1 (show NCOR1 Antibodies) expression by RNA interference in B cells resulted in an increased Prdm1 mRNA expression.
TCF1 (show HNF1A Antibodies) is required for the T follicular helper cell response to viral infection functioning through negative feedback loops with IL-2 (show IL2 Antibodies) and Blimp1.
Blimp1 was dispensable for survival of plasma cells. Blimp-1-deficient plasma cells retained their transcriptional identity but lost the ability to secrete antibody. Blimp-1 regulated many components of the unfolded protein response.
Blimp1 promoted the migration and adhesion of plasmablasts, silenced B cell-specific gene expression, antigen presentation and class-switch recombination in plasmablasts, and induced immunoglobulin gene transcription and secretion.
In a genetically engineered mouse model of soft tissue sarcoma that loss of GCN2 has no effect on tumor growth or animal survival.
Blimp-1 likely has distinct gene-regulating activities depending on the inflammatory or anti-inflammatory enhancer landscape created by a multi-factorial transcriptional complex
From these results, we defined the distinct functions of Blimp-1 and Akt (show AKT1 Antibodies) and provided mechanistic insights into the acquisition of pluripotency in Primordial germ cells.
LPS (show TLR4 Antibodies)-PG completely abrogates RANKL (show TNFSF11 Antibodies)-induced gene expression of B lymphocyte-induced maturation protein-1 (Blimp1), a global transcriptional repressor of anti-osteoclastogenic genes encoding Bcl6 (show BCL6 Antibodies), IRF8 (show IRF8 Antibodies), and MafB (show MAFB Antibodies)
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.
PR domain containing 1, with ZNF domain
, Blimp-1 protein
, B lymphocyte-induced maturation protein 1
, PR domain zinc finger protein 1
, PR domain-containing 1
, U boot
, B lymphocyte induced maturation protein 1
, PR domain zinc finger protein 1-like
, B-lymphocyte-induced maturation protein 1
, PRDI-binding factor-1
, beta-interferon gene positive-regulatory domain I binding factor
, B lymphocyte induced maturation protein
, PR domain containing 1 with ZNF domain
, PR domain-containing protein 1
, beta-interferon gene positive regulatory domain I-binding factor