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anti-Pappalysin 2 (PAPPA2) Antibodies

Metalloproteinase which specifically cleaves IGFBP-5. Additionally we are shipping Pappalysin 2 Kits (29) and Pappalysin 2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PAPPA2 23850  
PAPPA2 60676 Q9BXP8
PAPPA2 364027  
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Top anti-Pappalysin 2 Antibodies at antibodies-online.com

Showing 10 out of 42 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PAPPA2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: 293T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PAPPA2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 293T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PLAC3 in HeLa cell lysate with PLAC3 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB PAPPA2 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$385.00
Details

PAPPA2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Pappalysin 2 Antibodies

  1. Human Polyclonal PAPPA2 Primary Antibody for WB - ABIN2775475 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)

  2. Human Polyclonal PAPPA2 Primary Antibody for EIA, WB - ABIN783757 : Overgaard, Boldt, Laursen, Sottrup-Jensen, Conover, Oxvig: Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase. in The Journal of biological chemistry 2001 (PubMed)

More Antibodies against Pappalysin 2 Interaction Partners

Zebrafish Pappalysin 2 (PAPPA2) interaction partners

  1. Papp-a2 modulates Bmp and Notch (show NOTCH1 Antibodies) signaling by independent mechanisms in zebrafish embryos to control cranial cartilage development and angiogenesis.

Mouse (Murine) Pappalysin 2 (PAPPA2) interaction partners

  1. Locally-produced Pappa2 in osteoblasts, epiphysis, and metaphysis, is required for normal postnatal bone growth.

  2. Despite a dramatic disruption of the balance between circulating IGF-I (show IGF1 Antibodies), IGFBP-3 (show IGFBP3 Antibodies) and -5, we found no effects of Pappa2 deletion on glucose metabolism, weight gain or adiposity on a high-fat diet.

  3. Pappa2 deletion had no effect on female reproduction and subtle effects on male fertility.

  4. Pappa2 is responsible for the effects of the previously-identified QTL, demonstrating that natural variation in the Pappa2 gene contributes to variation in postnatal growth in mice

  5. investigation of biological role of PAPP-A2 using knockout mice, heterozygotes, primary fibroblasts: The most striking phenotype of PAPP-A2 KO mice was postnatal growth retardation. PAPP-A2 KO mice were fertile, but exhibited compromised fecundity.

  6. Elevated PAPPA2 levels are a consequence rather than a cause of pregnancy complications.

  7. The refinement of the target region to four genes and the finding that the QTL affects IGFBP-5 (show IGFBP5 Antibodies) levels suggest that PAPPA2 may be involved with normal postnatal growth

  8. Pappa2 expression also shows specific localization within the mouse embryo and therefore may play roles in fetal development, independent of its action in the placenta

Human Pappalysin 2 (PAPPA2) interaction partners

  1. PAPP-A2 is differentially expressed in different trophoblast populations and shows strong down regulation in the mid second trimester in chorionic villous samples.

  2. The association between this PAPPA2 single nucleotide polymorphism and developmental dysplasia of the hip was evaluated.

  3. The upregulation of PAPP-A2 observed in preeclampsia at term occurs early in pregnancy, before the symptoms develop.

  4. PAPPA2 may be upregulated in severe pre-eclampsia and, functionally, this may be mediated via increased placental hypoxia known to occur with this pregnancy disorder.

  5. The existence of this assay will enable an assessment of the biomarker potential of PAPP-A2 in pre-eclampsia as well as other clinical conditions.

  6. Association of a single nucleotide polymorphism in pregnancy-associated plasma protein-A2 with developmental dysplasia of the hip

  7. factors previously known to be highly expressed in preeclamptic placentae (PGE2 and TNF-alpha (show TNF Antibodies)), contribute to the upregulation of PAPPA2. results are consistent with the hypothesis that PAPPA2 is upregulated as a consequence of placental pathology

  8. Circulating IGFBP-5 (show IGFBP5 Antibodies) is proteolyzed by PAPP-A2 during pregnancy, resulting in increased IGF bioavailability, which may have important consequences for the development of the fetus and/or the well-being of the mother.

  9. PAPP-A2 in syncytiotrophoblast cells was dramatically increased in pre-eclampsia. Maternal serum concentrations of PAPP-A2 were also significantly elevated in pre-eclampsia as compared with uncomplicated pregnancy.

  10. Preeclampsia involves changes in the gene expression of PAPPA2 in placental cytotrophoblasts.

Cow (Bovine) Pappalysin 2 (PAPPA2) interaction partners

  1. Variants in the pregnancy-associated plasma protein-A2 gene on Bos taurus autosome 16 are associated with daughter calving ease and productive life in Holstein cattle.

Pappalysin 2 (PAPPA2) Antigen Profile

Protein Summary

Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.

Gene names and symbols associated with anti-Pappalysin 2 (PAPPA2) Antibodies

  • pappalysin 2 (PAPPA2) antibody
  • pappalysin 2 (pappa2) antibody
  • pappalysin 2 (Pappa2) antibody
  • pappalysin 2 (LOC100357077) antibody
  • PAPP-A2 antibody
  • PAPP-E antibody
  • PAPPE antibody
  • PLAC3 antibody
  • si:dkey-39f8.1 antibody

Protein level used designations for anti-Pappalysin 2 (PAPPA2) Antibodies

pappalysin 2 , pappalysin-2-like , placenta-specific 3 , pregnancy-associated plasma preproprotein-A2 , pregnancy-associated plasma protein-E , pappalysin-2 , pregnancy-associated plasma protein E1

GENE ID SPECIES
457543 Pan troglodytes
567038 Danio rerio
100021506 Monodelphis domestica
100052718 Equus caballus
100447000 Pongo abelii
100468592 Ailuropoda melanoleuca
100491868 Xenopus (Silurana) tropicalis
100567326 Anolis carolinensis
100582901 Nomascus leucogenys
23850 Mus musculus
60676 Homo sapiens
364027 Rattus norvegicus
100357077 Oryctolagus cuniculus
100736235 Cavia porcellus
100521390 Sus scrofa
480058 Canis lupus familiaris
538320 Bos taurus
429071 Gallus gallus
101118205 Ovis aries
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