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anti-Pituitary Tumor-Transforming 1 (PTTG1) Antibodies

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. Additionally we are shipping PTTG1 Proteins (14) and PTTG1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTTG1 9232 O95997
PTTG1 64193 P97613
PTTG1 30939 Q9CQJ7
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Top anti-PTTG1 Antibodies at antibodies-online.com

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IHC (p) 0.1 mg Log in to see 10 to 12 Days
$554.40
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of PTTG1 antibody (N-term) (ABIN391532) in Ramos cell line lysates (35 µg/lane). PTTG1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human testis tissue with PTTG1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from HepG2/Jurkat/293 cells, using PTTG1 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HuvEc cells, using PTTG1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from RAW264.7 cells, using PTTG Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PTTG Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated IF, IHC (p), IP, WB 0.1 mg Log in to see 6 to 8 Days
$357.50
Details
Human Rabbit Un-conjugated WB Anti-Securin antibody, Western blotting All lanes: Anti PTTG1  at 0.5ug/ml Lane 1: HELA Whole Cell Lysate at 40ug Lane 2: MCF-7 Whole Cell Lysate at 40ug Lane 3: SKOV Whole Cell Lysate at 40ug Lane 4: A375 Whole Cell Lysate at 40ug Predicted bind size: 22KD Observed bind size: 22KD 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Goat Un-conjugated IHC (p) Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p) 1 mL Log in to see 6 to 8 Days
$599.50
Details
Human Mouse Un-conjugated IHC (p), IHC Formalin-fixed, paraffin-embedded human tonsil stained with ABIN153436 using peroxidase-conjugate and AEC chromogen. Note nuclear staining of lympocytes in germinal center. 0.5 mL Log in to see 5 to 7 Days
$427.88
Details

PTTG1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
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Rat (Rattus) ,
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Mouse (Murine) , ,
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Top referenced anti-PTTG1 Antibodies

  1. Human Monoclonal PTTG1 Primary Antibody for IHC (p) - ABIN180460 : Wang, Liu, Wang, Qin, Elledge: Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. in Genes & development 2001 (PubMed)
    Show all 2 references for ABIN180460

  2. Human Polyclonal PTTG1 Primary Antibody for IHC, ELISA - ABIN1533781 : Yaspo, Aaltonen, Horelli-Kuitunen, Peltonen, Lehrach: Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3. in Genomics 1998 (PubMed)
    Show all 2 references for ABIN1533781

  3. Human Polyclonal PTTG1 Primary Antibody for IF, ELISA - ABIN1533575 : Domínguez, Ramos-Morales, Romero, Rios, Dreyfus, Tortolero, Pintor-Toro: hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG. in Oncogene 1998 (PubMed)

  4. Human Polyclonal PTTG1 Primary Antibody for IF, IHC (p) - ABIN391532 : Cui, Xu, Song, Zhao, Liu, Song: Pituitary tumor transforming gene: a novel therapeutic target for glioma treatment. in Acta biochimica et biophysica Sinica 2015 (PubMed)

More Antibodies against PTTG1 Interaction Partners

Human Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. Pttg1 may increase BC cell growth through nuclear exclusion of p27 (show PAK2 Antibodies), which highlights a novel molecular regulatory machinery in tumorigenesis of BC.

  2. Data show that overexpression of c-myc proto-oncogene (show MYC Antibodies) protein (show MYC Antibodies) could prevent the metabolic shift induced by pituitary tumor-transforming gene (PTTG) knockwown.

  3. Report feedback loop between PTTG1 targeting miRNAs, PTTG1 and p53 (show TP53 Antibodies) that promotes pituitary tumorigenesis.

  4. knockdown of PTTG1 increased expression of integrin alpha 4 (ITGA4 (show ITGA4 Antibodies)), ITGA5 (show ITGA5 Antibodies), and integrin beta 1 (ITGB1 (show ITGB1 Antibodies)); otherwise, RhoA (show RHOA Antibodies) expression was significantly decreased

  5. Data show that pituitary tumor-transforming 1 protein (PTTG1) is over-expressed in multiple myeloma (MM) patients and is associated with poor survival.

  6. Silencing of PTTG could also inhibit tumor growth, invasion, and angiogenesis in vivo. Our data indicated that PTTG might be a potential target for glioma treatment

  7. FoxM1 (show FOXM1 Antibodies) binds to PTTG1 promoter to enhance PTTG1 transcription, and FoxM1 (show FOXM1 Antibodies)-PTTG1 pathway promotes colorectal cancer migration and invasion

  8. we demonstrated here the inhibitory effect of CACP (show PRG4 Antibodies) on the growth of H22 cells in vitro and in vivo, which may be through, at least partly, repression of PTTG1 and then followed by the inactivation of P13/Akt (show AKT1 Antibodies) and activation of p38 (show CRK Antibodies) MARK signaling pathways

  9. our data suggest that Pttg1 may increase CC cell metastasis, which is negatively regulated by miR (show MLXIP Antibodies)-494

  10. PTTG1 enhances HBV replication through suppression of P53 (show TP53 Antibodies).

Pig (Porcine) Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. PTTG1 is a new candidate maternal effect (show NLRP5 Antibodies) gene that may participate in the processes of oocyte maturation and zygotic genome activation during embryogenesis

Mouse (Murine) Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. PTTG is functionally required for hepatic fibrosis progression in an animal model of chronic liver injury, and thus a potential treatment target.

  2. RasGrf1 (show RASGRF1 Antibodies) is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses.

  3. these results implicate Pttg1 in the regulation of homotypic spacing between specific types of retinal neurons.

  4. Pttg1/securin has roles in branching morphogenesis of the mammary gland and suppression of mammary tumorigenesis

  5. PBF (show PTTG1IP Antibodies) is the first protein to interact with the critical TH transporter MCT8 (show MCT8 Antibodies) and modulate its function in vivo

  6. CSN3 (show CSN3 Antibodies) and CSN5 (show COPS5 Antibodies) are involved in oocyte meiosis by regulating degradation of Cyclin B1 (show CCNB1 Antibodies) and Securin via APC (show APC Antibodies)/C.

  7. The genetically deleting Tff3 in mice altered down-regulated Pttg1 and up-regulated serpina3n expression, indicating a potential role of these factors during the development of presbyacusis.

  8. data reveal that up to 9 months of age, Pttg1(-/-) retinas have a healthy morphology and normal photoreceptor function

  9. Pituitary tumor transforming gene 1 (PTTG1), an oncogene (show RAB1A Antibodies), was the most up-regulated transcript in KLF6 (show KLF6 Antibodies)+/- liver. PTTG1 downregulation represents a novel tumor suppressor pathway of KLF6 (show KLF6 Antibodies).

  10. Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes.

PTTG1 Antigen Profile

Protein Summary

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Gene names and symbols associated with PTTG1

  • pituitary tumor-transforming 1 (PTTG1) antibody
  • pituitary tumor-transforming 1 (Pttg1) antibody
  • pituitary tumor-transforming gene 1 (Pttg1) antibody
  • AW555095 antibody
  • C87862 antibody
  • EAP1 antibody
  • HPTTG antibody
  • Pttg antibody
  • PTTG1 antibody
  • Pttg3 antibody
  • Securin antibody
  • TUTR1 antibody

Protein level used designations for PTTG1

pituitary tumor-transforming protein 1 , securin , pituitary tumor-transforming 1 , ESP1-associated protein 1 , pituitary tumor-transforming gene 1 protein , tumor-transforming protein 1 , Pituitary tumor transforming

GENE ID SPECIES
416158 Gallus gallus
479307 Canis lupus familiaris
510673 Bos taurus
539883 Bos taurus
696143 Macaca mulatta
9232 Homo sapiens
64193 Rattus norvegicus
397015 Sus scrofa
508043 Bos taurus
462238 Pan troglodytes
30939 Mus musculus
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