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POMC encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. Additionally we are shipping POMC Kits (127) and POMC Proteins (26) and many more products for this protein.
Showing 10 out of 222 products:
Human Polyclonal POMC Primary Antibody for IHC (fro), IF (p) - ABIN673209
Chao, Lu, Lee, Chen, Wang, Yang, Cheng, Liao, Ro: Early systemic granulocyte-colony stimulating factor treatment attenuates neuropathic pain after peripheral nerve injury. in PLoS ONE 2012
Show all 2 references for ABIN673209
Human Polyclonal POMC Primary Antibody for IF (p), IHC (p) - ABIN734048
Brestoff, Kim, Saenz, Stine, Monticelli, Sonnenberg, Thome, Farber, Lutfy, Seale, Artis: Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. in Nature 2015
Human Polyclonal POMC Primary Antibody for IHC, ELISA - ABIN185387
Mühlhäusler, Adam, Marrocco, Findlay, Roberts, McFarlane, Kauter, McMillen et al.: Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late ... in The Journal of physiology 2005
Human Monoclonal POMC Primary Antibody for EIA, IHC (p) - ABIN1105257
Hatakeyama, Inaba, Taniguchi, Miyamori: Functional adrenocorticotropic hormone receptor in cultured human vascular endothelial cells : possible role in control of blood pressure. in Hypertension 2000
Broad Bean (Vicia faba) Polyclonal POMC Primary Antibody for EIA, IHC (fro) - ABIN318390
Osamura, Watanabe, Nakai, Imura: Adrenocorticotropic hormone cells and immunoreactive beta-endorphin cells in the human pituitary gland: normal and pathologic conditions studied by the peroxidase-labeled antibody method. in The American journal of pathology 1980
Human Polyclonal POMC Primary Antibody for EIA, IHC (fro) - ABIN492746
Bicknell: The tissue-specific processing of pro-opiomelanocortin. in Journal of neuroendocrinology 2008
We identify the neuronal regulatory region of zebrafish pomca and confirm that it is not homologous to the mammalian enhancers.
Hypothalamic pro-opiomelanocortin and AgRP (show AGRP Antibodies) neurons are hypophysiotropic, projecting to the pituitary to coordinately regulate multiple pituitary hormones.
cloning and characterization of the pro-opiomelanocortin gene
Zebrafish proopiomelanocortin (zfPOMC) contains the consensus sequences for ACTH, gamma-LPH, beta-MSH and beta-endorphin (beta-END). RT-PCR expression studies indicate that zfPOMC is selectively expressed in nervous tissue and in the pituitary gland.
Pituitary expression of proopiomelanocortin provides a unique marker for pituitary anterior and intermediate lobe morphogenesis.
Data suggest that the solitary tract pro-opiomelanocortin (NTSPOMC) neurons were involved in cardiorespiratory control and endogenous analgesia.
hypothalamic arcuate nucleus (Arc (show NOL3 Antibodies))POMC-deficient mice, which develop severe obesity and insulin (show INS Antibodies) resistance, unexpectedly exhibit improved glucose tolerance and remain protected from hyperglycemia via decreased renal GLUT2 (show SLC2A2 Antibodies) expression and glycosuria.
Hypomethylation of POMC promoter occurred in the hypothalamus of the high sucrose diet offspring compared with controls.
Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R (show MC4R Antibodies)-SphK1 (show SPHK1 Antibodies) signaling.
These data indicate that glucose induces distinct excitatory synaptic plasticity in different subpopulations of POMC neurons.
Although genetic deletion of either Atg12 (show ATG12 Antibodies) or Atg5 (show ATG5 Antibodies) renders POMC neurons autophagy-deficient, mice lacking Atg5 (show ATG5 Antibodies) in POMC neurons do not exhibit these phenotypes.
Data indicate that LIM-homeodomain (show LHX2 Antibodies) transcription factor Islet 1 (show ISL1 Antibodies) is necessary for hypothalamic proopiomelanocortin gene (Pomc) expression during embryogenesis.
these results reveal that cooperative interactions between the enhancers confer robustness of Pomc expression against gene regulatory disturbances and preclude deleterious metabolic phenotypes caused by Pomc deficiency in adulthood
In contrast to mice with total hypothalamic Pomc deficiency, which are severely obese, mice with Lepr (show LEPR Antibodies)-restricted Pomc expression displayed fully normal body weight, food consumption, glucose homeostasis, and locomotor activity.
Data suggest FoxO1 (forkhead box O1 (show FOXO1 Antibodies)) region Gly140-Leu160 (Gln145, Arg147 (show DHX40 Antibodies), Lys148, Arg153, Arg154) is critical for FoxO1 (show FOXO1 Antibodies) interaction with Stat3 (show STAT3 Antibodies) (signal transducer/activator of transcription (show STAT1 Antibodies) 3) in down-regulation of leptin (show LEP Antibodies)-induced Pomc transcription.
these common variants in PCSK1 (show PCSK1 Antibodies) and POMC were not the major cause of obesity in the Thai subjects sampled. However, variants in PCSK1 (show PCSK1 Antibodies) did affect cholesterol level, LDL-C level, and waist circumference.
ACTH was readily detected at significantly higher levels in regions of ACTH-secreting adenomas and in normal anterior adenohypophysis compared with non-secreting adenoma and neurohypophysis.
CSF (show CSF2 Antibodies) POMC was higher in lean vs. overweight/obese subjects.
There was a non-linear association between leukocyte telomere length and plasma ACTH after laboratory stressor in elderly adults.
Synovial fluid alpha-MSH levels showed an independent and negative correlation with articular cartilage degeneration in patients with knee ACL (show ACLY Antibodies) deficiency.
This study suggest the involvement of genetic variants of POMC in the outcome of antidepressant treatment in patients with MDD, and indicate the possibility of an interaction of this association with stressful life events.
Term infants born with meconium-stained amniotic fluid (MSAF) and who experienced respiratory distress had significantly lower levels of ACTH and cortisol at birth compared with well term infants born with MSAF or clear amniotic fluid.
POMC-positive expression is a novel, independent poor prognostic marker.
the hypothalamic proopiomelanocortin neurons, have a key role in the control of food intake and energy metabolism.
Report clinicopathological/immunohistochemical features of ACTH-secreting pancreatic neoplasms.
The expression of the genes coding for proopiomelanocortin (POMC), proenkephalin (PENK (show PENK Antibodies)) and prodynorphin (PDYN (show PDYN Antibodies)) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
The association has been reported between polymorphisms of the CRH (show CRH Antibodies) and POMC genes with economic traits in Korean cattle.
Expression of the hepatic endocannabinoid system and proopiomelanocortin was altered by plane of dietary energy prepartum particularly during the first 2-week postpartum.
Significant associations were observed between POMC c.288C>T with start-of-finishing weight (SOF (show GJA1 Antibodies) WT; P = 0.04), hot carcass weight (HCW; P = 0.02), average fat and grade fat (both P = 0.05), carcass rib-eye area (REA (show PHB2 Antibodies); P = 0.03) and marbling
The polymorphism of POMC gene is associated with the growth traits of Nanyang cattle.
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
, adrenal corticotropic hormone
, adrenocorticotropic hormone
, alpha-melanocyte stimulating hormone
, corticotropin-like intermediary peptide
, melanotropin gamma
, alpha-melanocyte-stimulating hormone
, beta-melanocyte-stimulating hormone
, lipotropin beta
, lipotropin gamma
, melanotropin alpha
, melanotropin beta
, opiomelanocortin prepropeptide
, proopiomelanocortin preproprotein
, proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
, proopiomelanocortin, beta (endorphin, beta)
, proopoimelanocortin, beta (endorphin, beta)
, beta-melanocyte stimulating hormone
, pro-opiomelanocortin a-1
, pro-opiomelanocortin a-2
, pro-opiomelanocortin b-1
, pro-opiomelanocortin b-2