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anti-Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) Antibodies

The protein encoded by PTPRN is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPRN Kits (33) and PTPRN Proteins (15) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTPRN 5798 Q16849
PTPRN 19275  
PTPRN 116660 Q63259
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Top anti-PTPRN Antibodies at

Showing 10 out of 68 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Goat Un-conjugated ELISA, WB ABIN334423 (0.5µg/ml) staining of NIH 3T3 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
Mouse Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-PTPRN Antibody Titration: 0.0625ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB PTPRN Antibody (Center) (ABIN658444) western blot analysis in Jurkat cell line lysates (35 µg/lane). This demonstrates the PTPRN antibody detected the PTPRN protein (arrow). 400 μL Log in to see 10 to 11 Days
Mouse Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
Human Mouse Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
Human Mouse Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
Human Rabbit Un-conjugated WB PTPRN antibody used at 0.0625 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days

PTPRN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Mouse (Murine) ,

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Rat (Rattus) ,

Top referenced anti-PTPRN Antibodies

  1. Mouse (Murine) Polyclonal PTPRN Primary Antibody for ELISA, WB - ABIN334423 : Buzzetti, Di Pietro, Giaccari, Petrone, Locatelli, Suraci, Capizzi, Arpi, Bazzigaluppi, Dotta, Bosi: High titer of autoantibodies to GAD identifies a specific phenotype of adult-onset autoimmune diabetes. in Diabetes Care 2007 (PubMed)

More Antibodies against PTPRN Interaction Partners

Human Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) interaction partners

  1. Identification of amino acids contributing to distinct epitopes on IA-2, with both HLA-DR and HLA-DQ alleles influencing epitope specificity.

  2. RESP18HD is required for efficient sorting of ICA512 to secretory granules: RESP18HD is a key determinant for ICA512 granule targeting.

  3. The binding of CREB (show CREB1 Antibodies) to the promoter region, -216 to +115, enhanced IA-2 transcription by more than fivefold.

  4. Kaplan-Meier survival curves estimated a worst pancreas graft survival for patients with positive IA-2 antibodies versus those patients with negative auto-antibodies and GAD65 (show GAD2 Antibodies)+ auto-antibodies after simultaneous pancreas kidney transplantation.

  5. Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes.

  6. Letter: report lack of anti-IA2 autoantibodies in primary antiphospholipid syndrome.

  7. analysis of protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase (show ACP1 Antibodies) ICA512 ectodomain

  8. In families with type 1 diabetes, there was a female predominance and more family history of associated autoimmune diseases (AAIDs) in the group with AAIDs, and less frequent anti-IA-2 antibodies

  9. Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1 (show GREB1 Antibodies), TGIF (show IL10 Antibodies) and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C (show GUCY2C Antibodies)).

  10. Studies indicate that T1DM can be detected by determining four autoantibodies, namely those antibodies against insulin (show INS Antibodies), glutamic acid decarboxylase 65 (show GAD2 Antibodies), insulinoma (show RPS15 Antibodies) antigen (IA)-2 (ICA512) and the zinc transporter ZnT8 (show SLC30A8 Antibodies).

Mouse (Murine) Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) interaction partners

  1. Ptprn is an activity dependent gene in mouse olfactory sensory neurons. [Ptprn]

  2. Data show that miRNAs are involved in regulating the expression of the major type 1 diabetes (T1D) autoantigens IA-2, IA-2beta (show PTPRN2 Antibodies), and GAD65 (show GAD2 Antibodies) enzyme.

  3. Experiments showed that the knock-out of IA-2, but not IA-2beta (show PTPRN2 Antibodies), resulted in marked impairment of active avoidance learning; one copy of the gene was sufficient to maintain active avoidance learning

  4. Data show that the insulinoma associated protein-2 (show INSM2 Antibodies) distribution in peripheral neurons appeared more intensely in neurites rather than in the cell bodies.

  5. IA-2-/- mice had higher sensitivity to STZ, suggesting a role of IA-2 not only in the secretion but also in the production of insulin (show INS Antibodies).

  6. IA-2 is involved in glucose-stimulated insulin (show INS Antibodies) secretion

  7. experiments show that the dense core vesicle proteins IA-2 and IA-2beta (show PTPRN2 Antibodies), alone or in combination, are involved in insulin (show INS Antibodies) secretion, but neither alone nor in combination are they required for the development of diabetes in NOD mice

  8. IA-2beta (show PTPRN2 Antibodies), but not IA-2, is induced by ghrelin (show GHRL Antibodies) and inhibits glucose-stimulated insulin (show INS Antibodies) secretion

  9. The cleaved cytosolic fragment of ICA512 enhances the transcription of secretory granule genes (including its own gene) by binding to tyrosine phosphorylated signal transducers and activators of transcription (STAT) 5 (show STAT5A Antibodies) and preventing its dephosphorylation.

  10. IA-2 beta (show PTPRN2 Antibodies) undergoes at least three distinct proteolytic cleavages.

PTPRN Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with PTPRN

  • protein tyrosine phosphatase, receptor type, N (PTPRN) antibody
  • protein tyrosine phosphatase, receptor type, N (Ptprn) antibody
  • Ia-2 antibody
  • IA-2/PTP antibody
  • IA2 antibody
  • ICA512 antibody
  • mIA-A antibody
  • mKIAA4064 antibody
  • R-PTP-N antibody

Protein level used designations for PTPRN

ICA 512 , PTP IA-2 , islet cell antigen 2 , islet cell antigen 512 , islet cell autoantigen 3 , protein tyrosine phosphatase-like N , receptor-type tyrosine-protein phosphatase-like N , ICA512 , R-PTP-N , islet cell autoantigen 512 , protein tyrosine phosphatase, receptor-type, N , 105 kDa islet cell antigen , BEM-3 , ICA105 , PTPLP , brain-enriched membrane-associated protein tyrosine phosphatase , insulinoma antigen-2 , receptor type N protein tyrosine phosphatase

5798 Homo sapiens
286810 Bos taurus
19275 Mus musculus
116660 Rattus norvegicus
100355368 Oryctolagus cuniculus
100733759 Cavia porcellus
100155609 Sus scrofa
478921 Canis lupus familiaris
101113312 Ovis aries
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