PTPRN antibody (Middle Region)

Catalog No. ABIN2782197

The Rabbit Polyclonal anti-PTPRN antibody is suitable to detect PTPRN in samples from Human, Rat, Mouse, Cow, Pig, Guinea Pig, Rabbit, Dog and Horse. It has been validated for WB.

Quick Overview for PTPRN antibody (Middle Region) (ABIN2782197)

Target: PTPRN (Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN))

Reactivity: Human, Rat, Mouse, Cow, Pig, Guinea Pig, Rabbit, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPRN antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PTPRN Antibody

Binding Specificity: Middle Region

Sequence: EVQQVPSPVS SEPPKAARPP VTPVLLEKKS PLGQSQPTVA GQPSARPAAE

Predicted Reactivity: Cow: 86%, Dog: 100%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 86%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PTPRN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PTPRN

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 591 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PTPRN

Target: PTPRN (Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN))

Alternative Name: PTPRN

Background: PTPRN is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.
Alias Symbols: FLJ16131, IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N
Protein Interaction Partner: PLP1, MAL, CLN8, UBQLN4, SNX19, SPTBN4, PTPRT, MADD, PTPRS, SNTB2, NOS1, PPIA, CAPN2,
Protein Size: 889

Molecular Weight: 96 kDa

Gene ID: 5798

NCBI Accession: NM_001199763

UniProt: Q16849