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SETDB1 encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. Additionally we are shipping SETDB1 Proteins (7) and many more products for this protein.
Showing 10 out of 109 products:
Human Monoclonal SETDB1 Primary Antibody for IF, WB - ABIN394317
Mavaddat, Dunning, Ponder, Easton, Pharoah: Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009
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Human Polyclonal SETDB1 Primary Antibody for EIA, WB - ABIN356608
Maclean: The Action of Muscarin and Pilocarpin on the Hearts of Certain Vertebrates, with Observations on Seasonal Changes. in The Biochemical journal 2006
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Human Polyclonal SETDB1 Primary Antibody for WB - ABIN387924
Ichimura, Watanabe, Sakamoto, Aoto, Fujita, Nakao: Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins. in The Journal of biological chemistry 2005
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Human Polyclonal SETDB1 Primary Antibody for EIA, WB - ABIN117938
Schultz, Ayyanathan, Negorev, Maul, Rauscher: SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. in Genes & development 2002
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Human Monoclonal SETDB1 Primary Antibody for EIA, IF - ABIN1108988
Gevaert, Staes, Van Damme, De Groot, Hugelier, Demol, Martens, Goethals, Vandekerckhove: Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. in Proteomics 2005
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Human Monoclonal SETDB1 Primary Antibody for EIA, WB - ABIN1108987
Rosendorff, Sakakibara, Lu, Kieff, Xuan, DiBacco, Shi, Shi, Gill: NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. in Proceedings of the National Academy of Sciences of the United States of America 2006
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SETDB1 is essential for the earliest events in lineage specification in the bovine blastocyst.
These results suggest that SETDB1- mediated FosB (show FOSB Antibodies) expression is a common molecular phenomenon, and might be a novel pathway responsible for the increase in cell proliferation that frequently occurs during anticancer drug therapy.
SETDB1 mutations are associated with malignant pleural mesotheliomas.
Upon HBV infection, cellular mechanisms involving SETDB1-mediated H3K9me3 and HP1 (show DEFA1 Antibodies) induce silencing of HBV cccDNA transcription through modulation of chromatin structure.
The SETDB1 protein was closely associated with the prognosis of prostate cancer (PCa (show FLVCR1 Antibodies)). Bioinformatics suggested that SETDB1 might promote PCa (show FLVCR1 Antibodies) bone metastasis through the WNT (show WNT2 Antibodies) pathway. In conclusion, SETDB1 might be associated with the development of bone metastases from PCa (show FLVCR1 Antibodies)
results indicate that ATF7IP (show ATF7IP Antibodies) does not directly modulate SETDB1 catalytic activity, suggesting alternate roles, such as affecting cellular localization or mediating interaction with additional binding partners.
SETDB1 is an oncogene (show RAB1A Antibodies) that is frequently up-regulated in human HCCs (show HCCS Antibodies); the multiplicity of SETDB1 activating mechanisms at the chromosomal, transcriptional, and posttranscriptional levels together facilitates SETDB1 up-regulation in human HCC (show FAM126A Antibodies)
regulates cancer cell growth via methylation of p53 (show TP53 Antibodies)
SETDB1, localized in the nucleus, might undergo degradation by the proteasome and be exported to the cytosol, resulting in its detection mainly in the cytosol.
Exogenous expression of MyoD (show MYOD1 Antibodies) reversed transcriptional repression of MyoD (show MYOD1 Antibodies) promoter-driven lucif-erase reporter by Setdb1 shRNA and rescued myogenic differentiation of C2C12 myoblast cells depleted of endogenous Setdb1.
Authors demonstrate that a KMT1E-containing complex directly interacts with the FcgammaRIIb promoter and that histone H3 (show HIST3H3 Antibodies) at lysine 9 tri (show VANGL2 Antibodies)-methylation at this promoter is dependent on Setdb1
Setdb1 is a maternal-effect (show NLRP5 Antibodies) gene that controls meiotic progression and is essential for early embryogenesis. Setdb1 is an important regulator of Cdc14b (show CDC14B Antibodies).
The currently identified reciprocal action between SETDB1 and PRC2 reveals a novel mechanism underlying ES cell pluripotency and differentiation regulation.
Data show that histone methyltransferase SETDB1 functions as an epigenetic repressor of all endogenous retroviruses (ERVs) in B lymphocytes.
these findings reveal a novel regulatory hierarchy governing SETDB1 recruitment and in turn, transcriptional silencing in mESCs.
ESET regulated spermatogonial stem cells apoptosis.
SETDB1 is an essential guardian against proviral expression prior to the onset of de novo DNA methylation (show HELLS Antibodies) in the germline
Setdb1 promotes the persistence of DNA methylation (show HELLS Antibodies) in embryonic stem cells, likely reflecting a mechanism by which DNA methylation (show HELLS Antibodies) is maintained at LTR retrotransposons and imprinted genes during developmental stages when DNA methylation (show HELLS Antibodies) is reprogrammed.
ESET is a critical regulator of osteoblast differentiation during bone development.
presume that the cytoplasmic retention of over-expressed Setdb1 occurs as part of a regulatory mechanism to set a tight limit on the nuclear activity of Setdb1, whose excess activity might result in random and haphazard chromatin modifications that cause globally aberrant gene expression
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.
histone-lysine N-methyltransferase SETDB1
, SET domain, bifurcated 1
, histone-lysine N-methyltransferase SETDB1-like
, histone-lysine N-methyltransferase SETDB1-A
, ERG-associated protein with SET domain
, ERG-associated protein with a SET domain, ESET
, H3-K9-HMTase 4
, histone H3-K9 methyltransferase 4
, histone-lysine N-methyltransferase, H3lysine-9 specific 4
, lysine N-methyltransferase 1E
, tudor domain containing 21
, SET domain ERG-associated histone methyltransferase