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anti-SET Domain, Bifurcated 1 (SETDB1) Antibodies

SETDB1 encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. Additionally we are shipping SETDB1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SETDB1 689883  
SETDB1 9869 Q15047
SETDB1 84505  
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Top anti-SETDB1 Antibodies at antibodies-online.com

Showing 10 out of 104 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-SETDB1 Pab(ABIN387924) in Ramos cell line lysate (35 µg/lane). SETDB1(arrow) was detected using the purified polyclonal antibody (1:60 dilution). Western blot analysis of SETDB1(arrow) using rabbit polyclonal SETDB1 Antibody (C-term) (ABIN387924). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the SETDB1 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to SETDB1 on HeLa cell (antibody concentration 10 µg/mL). SETDB1 monoclonal antibody (M07), clone 4A3 Western Blot analysis of SETDB1 expression in SW-13. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis is shown using anti-ESET antibody to detect human ESET present in a 293 whole cell lysate. ~30ug of lysate was loaded per lane for SDS-PAGE. Comparison to a molecular weight marker (not shown) indicates a single band of ~170 kDa is detected. Peptide competition (not shown) blocks staining of this band. The blot was incubated with a 1:1000 dilution of the antibody at room temperature for 2 h followed by detection using IRDye™800 labeled Goat-a-Rabbit IgG [H&L] diluted 1:5,000 for 45 min. IRDye™800 fluorescence image was captured using the Odyssey® Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Other detection systems will yield similar results. 0.1 mg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using SETDB1 mouse mAb against MCF-7 (1) ,T47D (2), HEK293 (3), JURKAT (4), NIH/3T3 (5) and F9 (6) cell lysate. 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Mouse Un-conjugated ICC, ELISA, WB Figure 1: Immunofluorescence analysis of LOVO cells using SETDB1 mouse mAb (green) . Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Figure 2: Western blot analysis using SETDB1 mouse mAb against MCF-7 (1) ,T47D (2), HEK293 (3), JURKAT (4), NIH/3T3 (5), F9 (6), RAW246.7 (7) and Cos7 (8) cell lysate. 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Mouse Un-conjugated EIA, WB 0.1 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated EIA, IF, WB 0.1 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ICC, IF, IHC, ELISA, WB 100 μL Log in to see 8 to 10 Days
$522.50
Details
Human Mouse Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$522.50
Details

SETDB1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SETDB1 Antibodies

  1. Human Monoclonal SETDB1 Primary Antibody for IF, WB - ABIN394317 : Mavaddat, Dunning, Ponder, Easton, Pharoah: Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009 (PubMed)
    Show all 5 references for ABIN394317

  2. Human Polyclonal SETDB1 Primary Antibody for EIA, WB - ABIN356608 : Maclean: The Action of Muscarin and Pilocarpin on the Hearts of Certain Vertebrates, with Observations on Seasonal Changes. in The Biochemical journal 2006 (PubMed)
    Show all 5 references for ABIN356608

  3. Human Polyclonal SETDB1 Primary Antibody for WB - ABIN387924 : Ichimura, Watanabe, Sakamoto, Aoto, Fujita, Nakao: Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins. in The Journal of biological chemistry 2005 (PubMed)
    Show all 4 references for ABIN387924

  4. Human Polyclonal SETDB1 Primary Antibody for EIA, WB - ABIN117938 : Schultz, Ayyanathan, Negorev, Maul, Rauscher: SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. in Genes & development 2002 (PubMed)
    Show all 4 references for ABIN117938

  5. Human Monoclonal SETDB1 Primary Antibody for EIA, IF - ABIN1108988 : Gevaert, Staes, Van Damme, De Groot, Hugelier, Demol, Martens, Goethals, Vandekerckhove: Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. in Proteomics 2005 (PubMed)
    Show all 2 references for ABIN1108988

  6. Human Monoclonal SETDB1 Primary Antibody for EIA, WB - ABIN1108987 : Rosendorff, Sakakibara, Lu, Kieff, Xuan, DiBacco, Shi, Shi, Gill: NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 2 references for ABIN1108987

More Antibodies against SETDB1 Interaction Partners

Cow (Bovine) SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. SETDB1 is essential for the earliest events in lineage specification in the bovine blastocyst.

Human SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. results indicate that ATF7IP (show ATF7IP Antibodies) does not directly modulate SETDB1 catalytic activity, suggesting alternate roles, such as affecting cellular localization or mediating interaction with additional binding partners.

  2. SETDB1 is an oncogene (show RAB1A Antibodies) that is frequently up-regulated in human HCCs (show HCCS Antibodies); the multiplicity of SETDB1 activating mechanisms at the chromosomal, transcriptional, and posttranscriptional levels together facilitates SETDB1 up-regulation in human HCC (show FAM126A Antibodies)

  3. regulates cancer cell growth via methylation of p53 (show TP53 Antibodies)

  4. SETDB1, localized in the nucleus, might undergo degradation by the proteasome and be exported to the cytosol, resulting in its detection mainly in the cytosol.

  5. Exogenous expression of MyoD (show MYOD1 Antibodies) reversed transcriptional repression of MyoD (show MYOD1 Antibodies) promoter-driven lucif-erase reporter by Setdb1 shRNA and rescued myogenic differentiation of C2C12 myoblast cells depleted of endogenous Setdb1.

  6. Authors demonstrate that a KMT1E-containing complex directly interacts with the FcgammaRIIb promoter and that histone H3 (show HIST3H3 Antibodies) at lysine 9 tri (show VANGL2 Antibodies)-methylation at this promoter is dependent on Setdb1

  7. MiR-7 (show LILRB1 Antibodies), inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the Epithelial-mesenchymal transition of breast cancer stem cells by down regulating the STAT3 (show STAT3 Antibodies) pathway

  8. Report elevated levels of SETDB1 in non-small lung cancers, associated with neoplasm grading and tumor growth.

  9. This observation suggests that the ZNF274 (show ZNF274 Antibodies)/SETDB1 complex bound to the SNORD116 cluster may protect the Prader-Willi syndrome induced pluripotent cells from DNA demethylation during early development.

  10. Together, our findings defined an essential role for the KMT1E/SMAD2 (show SMAD2 Antibodies)/3 repressor complex in TGFbeta (show TGFB1 Antibodies)-mediated lung cancer metastasis.

Mouse (Murine) SET Domain, Bifurcated 1 (SETDB1) interaction partners

  1. Setdb1 is a maternal-effect (show NLRP5 Antibodies) gene that controls meiotic progression and is essential for early embryogenesis. Setdb1 is an important regulator of Cdc14b (show CDC14B Antibodies).

  2. The currently identified reciprocal action between SETDB1 and PRC2 reveals a novel mechanism underlying ES cell pluripotency and differentiation regulation.

  3. regulates cancer cell growth via methylation of p53 (show TP53 Antibodies)

  4. Data show that histone methyltransferase SETDB1 functions as an epigenetic repressor of all endogenous retroviruses (ERVs) in B lymphocytes.

  5. these findings reveal a novel regulatory hierarchy governing SETDB1 recruitment and in turn, transcriptional silencing in mESCs.

  6. ESET regulated spermatogonial stem cells apoptosis.

  7. SETDB1 is an essential guardian against proviral expression prior to the onset of de novo DNA methylation (show HELLS Antibodies) in the germline

  8. Setdb1 promotes the persistence of DNA methylation (show HELLS Antibodies) in embryonic stem cells, likely reflecting a mechanism by which DNA methylation (show HELLS Antibodies) is maintained at LTR retrotransposons and imprinted genes during developmental stages when DNA methylation (show HELLS Antibodies) is reprogrammed.

  9. ESET is a critical regulator of osteoblast differentiation during bone development.

  10. presume that the cytoplasmic retention of over-expressed Setdb1 occurs as part of a regulatory mechanism to set a tight limit on the nuclear activity of Setdb1, whose excess activity might result in random and haphazard chromatin modifications that cause globally aberrant gene expression

SETDB1 Antigen Profile

Protein Summary

This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.

Gene names and symbols associated with SETDB1

  • SET domain, bifurcated 1 (Setdb1) antibody
  • SET domain, bifurcated 1 (SETDB1) antibody
  • SET domain, bifurcated 1a (setdb1a) antibody
  • SET domain, bifurcated 1 (setdb1) antibody
  • AU022152 antibody
  • ESET antibody
  • fc07d03 antibody
  • H3-K9-HMTase4 antibody
  • KG1T antibody
  • KMT1E antibody
  • mKIAA0067 antibody
  • NV10069 antibody
  • SETDB1 antibody
  • si:ch211-81a5.6 antibody
  • TDRD21 antibody
  • wu:fc07d03 antibody

Protein level used designations for SETDB1

histone-lysine N-methyltransferase SETDB1 , SET domain, bifurcated 1 , histone-lysine N-methyltransferase SETDB1-like , histone-lysine N-methyltransferase SETDB1-A , ERG-associated protein with SET domain , ERG-associated protein with a SET domain, ESET , H3-K9-HMTase 4 , histone H3-K9 methyltransferase 4 , histone-lysine N-methyltransferase, H3lysine-9 specific 4 , lysine N-methyltransferase 1E , tudor domain containing 21 , SET domain ERG-associated histone methyltransferase

GENE ID SPECIES
689883 Rattus norvegicus
395847 Gallus gallus
469481 Pan troglodytes
716141 Macaca mulatta
100120014 Nasonia vitripennis
100138100 Bos taurus
100157920 Sus scrofa
100411734 Callithrix jacchus
100461671 Pongo abelii
100482250 Ailuropoda melanoleuca
553292 Danio rerio
9869 Homo sapiens
84505 Mus musculus
432147 Xenopus laevis
Selected quality suppliers for anti-SETDB1 (SETDB1) Antibodies
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