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anti-SH2 Domain Containing 1A (SH2D1A) Antibodies

SH2D1A encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. Additionally we are shipping SH2 Domain Containing 1A Proteins (19) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SH2D1A 4068 O60880
SH2D1A 501502 B2RZ59
SH2D1A 20400 O88890
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Top anti-SH2 Domain Containing 1A Antibodies at antibodies-online.com

Showing 10 out of 119 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN185426 staining (0.3µg/ml) of Human Thymus lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated IP, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB SH2D1A Antibody (C-term) (ABIN1881802) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the SH2D1A antibody detected the SH2D1A protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SH2D1A Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Jurkat cell lysate WB Suggested Anti-SH2D1A  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: Jurkat cell lysate  SH2D1A is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB SH2D1A monoclonal antibody (M01), clone 1C9 Western Blot analysis of SH2D1A expression in Jurkat . Western Blot analysis of SH2D1A expression in transfected 293T cell line by SH2D1A monoclonal antibody (M01), clone 1C9.Lane 1: SH2D1A transfected lysate(14.2 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated WB SH2D1A monoclonal antibody (M01), clone 1C9 Western Blot analysis of SH2D1A expression in Jurkat. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Cow Rabbit Un-conjugated WB Western blot analysis of SH2D1A expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details

SH2D1A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SH2 Domain Containing 1A Antibodies

  1. Human Monoclonal SH2D1A Primary Antibody for ELISA, WB - ABIN561703 : Ma, Suryani, Avery, Chan, Nanan, Santner-Nanan, Deenick, Tangye: Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12. in Immunology and cell biology 2009 (PubMed)
    Show all 5 references for ABIN561703

  2. Human Polyclonal SH2D1A Primary Antibody for WB - ABIN1881802 : Snow, Marsh, Krummey, Roehrs, Young, Zhang, van Hoff, Dhar, Nichols, Filipovich, Su, Bleesing, Lenardo: Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. in The Journal of clinical investigation 2009 (PubMed)
    Show all 5 references for ABIN1881802

  3. Human Polyclonal SH2D1A Primary Antibody for WB - ABIN374582 : Mikhalap, Shlapatska, Yurchenko, Yurchenko, Berdova, Nichols, Clark, Sidorenko: The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells. in Blood 2004 (PubMed)

  4. Human Polyclonal SH2D1A Primary Antibody for WB - ABIN374629 : Romero, Benítez, March, Vilella, Miralpeix, Engel: Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). in Tissue antigens 2004 (PubMed)

  5. Human Polyclonal SH2D1A Primary Antibody for IP, WB - ABIN265020 : Sayos, Wu, Morra, Wang, Zhang, Allen, van Schaik, Notarangelo, Geha, Roncarolo, Oettgen, De Vries, Aversa, Terhorst: The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. in Nature 1998 (PubMed)

More Antibodies against SH2 Domain Containing 1A Interaction Partners

Human SH2 Domain Containing 1A (SH2D1A) interaction partners

  1. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  2. The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation

  3. Study of SAP (show APCS Antibodies) expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 (show CD244 Antibodies) functional assay allows identification of all cases

  4. Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP (show APCS Antibodies) exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM (show SLAMF1 Antibodies) peptide.

  5. Signaling lymphocytic activation molecule (SLAM)/SLAM (show SLAMF1 Antibodies)-associated protein pathway regulates human B-cell tolerance.

  6. In patients suffering from X-linked lymphoproliferative disease (XLP1), SAP (show APCS Antibodies) is nonfunctional, not only abolishing the activating function of 2B4 (show CD244 Antibodies), but rendering this receptor inhibitory.

  7. our data reveal how SAP (show APCS Antibodies) nucleates a previously unknown signaling complex involving NTB-A (show SLAMF6 Antibodies) and LCK (show LCK Antibodies) to potentiate restimulation-induced cell death of activated human T cells.

  8. SAP (show APCS Antibodies) is a new actor downstream of PECAM-1 (show PECAM1 Antibodies) and its binding regulates PECAM-1 (show PECAM1 Antibodies) mediated cell adhesion.

  9. An intronic single nucleotide polymorphism of the SH2D1A gene is associated with systemic lupus erythematosus.

  10. Result suggests that p53 (show TP53 Antibodies) contributes to T cell homeostasis through the induction of the pro-apoptotic SAP (show APCS Antibodies).

Mouse (Murine) SH2 Domain Containing 1A (SH2D1A) interaction partners

  1. SAP (show APCS Antibodies) is an essential molecule for autoimmune antibody production.

  2. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  3. SLAM (show SLAMF1 Antibodies)-SAP (show APCS Antibodies) signaling promotes differentiation of IL-17 (show IL17A Antibodies)-producing T cells and progression of experimental autoimmune encephalomyelitis.

  4. these data suggest that SAP (show APCS Antibodies) is critical for regulating type II NKT (show CTSL1 Antibodies) cell responses.

  5. functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability

  6. Here we report that B cell intrinsic responses to haptenated protein antigens are impaired in SAP (show APCS Antibodies)-/- mice and in Rag-/- mice into which B cells derived from SAP (show APCS Antibodies)-/- mice together with wt CD4 (show CD4 Antibodies)+ T cells had been transferred.

  7. SAP (show APCS Antibodies) plays an essential role in CIA (show NCOA5 Antibodies) because of Fyn (show FYN Antibodies)-independent and Fyn (show FYN Antibodies)-dependent effects on TFH cells and, possibly, other T cell types.

  8. SAP (show APCS Antibodies) was required not only for the initiation but also for the progression of primary T cell-driven B cell responses to haptens.

  9. Loss of SAP (show APCS Antibodies) expression is associated with invariant NKT (show CTSL1 Antibodies) cell cytotoxicity and defective lytic synapse formation.

  10. SAP (show APCS Antibodies) is required for the development of innate phenotype in H2-M3--restricted Cd8 (show CD8A Antibodies)(+) T cells.

SH2 Domain Containing 1A (SH2D1A) Antigen Profile

Protein Summary

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SH2D1A

  • SH2 domain containing 1A (SH2D1A) antibody
  • SH2 domain containing 1A (Sh2d1a) antibody
  • SH2 domain protein 1A (Sh2d1a) antibody
  • SH21A (LOC780420) antibody
  • DSHP antibody
  • EBVS antibody
  • Gm686 antibody
  • IMD5 antibody
  • LYP antibody
  • MTCP1 antibody
  • RGD1562408 antibody
  • SAP antibody
  • SAP/SH2D1A antibody
  • SH2D1A antibody
  • XLP antibody
  • XLPD antibody

Protein level used designations for SH2D1A

Duncan disease SH2-protein , SH2 domain-containing protein 1A , SLAM associated protein/SH2 domain protein 1A , SLAM-associated protein , T cell signal transduction molecule SAP , T-cell signal transduction molecule SAP , signaling lymphocyte activation molecule-associated protein , signaling lymphocytic activation molecule-associated protein , SH2 domain protein 1A , SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome) , Signaling lymphocytic activation molecule-associated protein , Duncan disease homolog

GENE ID SPECIES
4068 Homo sapiens
501502 Rattus norvegicus
613356 Bos taurus
574156 Macaca mulatta
20400 Mus musculus
780420 Sus scrofa
Selected quality suppliers for anti-SH2 Domain Containing 1A (SH2D1A) Antibodies
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