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SH2 Domain Containing 1A (SH2D1A) ELISA Kits

SH2D1A encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. Additionally we are shipping SH2 Domain Containing 1A Antibodies (117) and SH2 Domain Containing 1A Proteins (19) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human SH2D1A SH2D1A 4068 O60880
Anti-Rat SH2D1A SH2D1A 501502 B2RZ59
Anti-Mouse SH2D1A SH2D1A 20400 O88890
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More ELISA Kits for SH2 Domain Containing 1A Interaction Partners

Human SH2 Domain Containing 1A (SH2D1A) interaction partners

  1. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  2. The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation

  3. Study of SAP (show APCS ELISA Kits) expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 (show CD244 ELISA Kits) functional assay allows identification of all cases

  4. Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP (show APCS ELISA Kits) exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM (show SLAMF1 ELISA Kits) peptide.

  5. Signaling lymphocytic activation molecule (SLAM)/SLAM (show SLAMF1 ELISA Kits)-associated protein pathway regulates human B-cell tolerance.

  6. In patients suffering from X-linked lymphoproliferative disease (XLP1), SAP (show APCS ELISA Kits) is nonfunctional, not only abolishing the activating function of 2B4 (show CD244 ELISA Kits), but rendering this receptor inhibitory.

  7. our data reveal how SAP (show APCS ELISA Kits) nucleates a previously unknown signaling complex involving NTB-A (show SLAMF6 ELISA Kits) and LCK (show LCK ELISA Kits) to potentiate restimulation-induced cell death of activated human T cells.

  8. SAP (show APCS ELISA Kits) is a new actor downstream of PECAM-1 (show PECAM1 ELISA Kits) and its binding regulates PECAM-1 (show PECAM1 ELISA Kits) mediated cell adhesion.

  9. An intronic single nucleotide polymorphism of the SH2D1A gene is associated with systemic lupus erythematosus.

  10. Result suggests that p53 (show TP53 ELISA Kits) contributes to T cell homeostasis through the induction of the pro-apoptotic SAP (show APCS ELISA Kits).

Mouse (Murine) SH2 Domain Containing 1A (SH2D1A) interaction partners

  1. SAP (show APCS ELISA Kits) is an essential molecule for autoimmune antibody production.

  2. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  3. SLAM (show SLAMF1 ELISA Kits)-SAP (show APCS ELISA Kits) signaling promotes differentiation of IL-17 (show IL17A ELISA Kits)-producing T cells and progression of experimental autoimmune encephalomyelitis.

  4. these data suggest that SAP (show APCS ELISA Kits) is critical for regulating type II NKT (show CTSL1 ELISA Kits) cell responses.

  5. functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability

  6. Here we report that B cell intrinsic responses to haptenated protein antigens are impaired in SAP (show APCS ELISA Kits)-/- mice and in Rag-/- mice into which B cells derived from SAP (show APCS ELISA Kits)-/- mice together with wt CD4 (show CD4 ELISA Kits)+ T cells had been transferred.

  7. SAP (show APCS ELISA Kits) plays an essential role in CIA (show NCOA5 ELISA Kits) because of Fyn (show FYN ELISA Kits)-independent and Fyn (show FYN ELISA Kits)-dependent effects on TFH cells and, possibly, other T cell types.

  8. SAP (show APCS ELISA Kits) was required not only for the initiation but also for the progression of primary T cell-driven B cell responses to haptens.

  9. Loss of SAP (show APCS ELISA Kits) expression is associated with invariant NKT (show CTSL1 ELISA Kits) cell cytotoxicity and defective lytic synapse formation.

  10. SAP (show APCS ELISA Kits) is required for the development of innate phenotype in H2-M3--restricted Cd8 (show CD8A ELISA Kits)(+) T cells.

SH2 Domain Containing 1A (SH2D1A) Antigen Profile

Antigen Summary

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SH2D1A

  • SH2 domain containing 1A (SH2D1A) antibody
  • SH2 domain containing 1A (Sh2d1a) antibody
  • SH2 domain protein 1A (Sh2d1a) antibody
  • SH21A (LOC780420) antibody
  • DSHP antibody
  • EBVS antibody
  • Gm686 antibody
  • IMD5 antibody
  • LYP antibody
  • MTCP1 antibody
  • RGD1562408 antibody
  • SAP antibody
  • SAP/SH2D1A antibody
  • SH2D1A antibody
  • XLP antibody
  • XLPD antibody

Protein level used designations for SH2D1A

Duncan disease SH2-protein , SH2 domain-containing protein 1A , SLAM associated protein/SH2 domain protein 1A , SLAM-associated protein , T cell signal transduction molecule SAP , T-cell signal transduction molecule SAP , signaling lymphocyte activation molecule-associated protein , signaling lymphocytic activation molecule-associated protein , SH2 domain protein 1A , SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome) , Signaling lymphocytic activation molecule-associated protein , Duncan disease homolog

GENE ID SPECIES
4068 Homo sapiens
501502 Rattus norvegicus
613356 Bos taurus
574156 Macaca mulatta
20400 Mus musculus
780420 Sus scrofa
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